Peptide having blood coagulation activity, and use thereof
The present invention relates to a peptide, of a novel sequence, characterized by being gelled in accordance with the pH condition. Since the peptide may induce blood coagulation, a composition comprising the peptide can be utilized for the use of inducing hemostasis.
1 . A peptide having pH-dependent gelation property, which comprises the amino acid sequence of SEQ ID NO: 1.
2 . The peptide according to claim 1 , wherein the peptide gelates at pH 4 to pH 8.
3 . The peptide according to claim 1 , wherein the peptide can induce blood coagulation.
4 . A composition for inducing hemostasis, comprising the peptide of claim 1 .
5 . The composition for inducing hemostasis according to claim 4 , wherein the peptide is contained in the composition at a concentration of 0.5 mg/ml to 50 mg/ml.
6 . The composition for inducing hemostasis according to claim 4 , wherein the composition further comprises calcium ions.
7 . The composition for inducing hemostasis according to claim 4 , wherein the composition coagulates blood at pH 4 to pH 8.
8 . The composition for inducing hemostasis according to claim 4 , wherein the composition coagulates blood under the condition that the salt concentration is 50 mM or more.
9 . The composition for inducing hemostasis according to claim 4 , wherein the composition does not cause hemolysis.
10 . The composition for inducing hemostasis according to claim 4 , wherein the composition is in the form of at least one selected from the group consisting of powder formulations, patches, gauze, sprays and injections.
11 . A method for hemostasis comprising the step of treating the composition of claim 4 to a bleeding site of an animal in which bleeding occurs.