IP Library › Granted Patent US 12,708,511
Granted Patent B2
US 12,708,511 · App. 18/814,988 · Granted Aug 18, 2026

Prosthetic atrio-ventricular valve

Inventors: Ehud Raanani (Hod-HaSharon, IL); Boris Orlov (Haifa, IL); Boaz Harari (Haifa, IL); Oded Meiri (Moshav Ram-On, IL); Lichen Rozitsky (Haifa, IL)
Assignee: SHEBA IMPACT LTD.
A61F2/2418A61F2/243A61F2/2436A61F2/2457A61F2220/0008A61F2220/0016A61F2220/0058A61F2220/0075A61F2230/0013A61F2230/005A61F2230/0078A61F2250/006
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Quick Facts
Patent No.
US 12,708,511
App. No.
18/814,988
Filed
Aug 26, 2024
Granted
Aug 18, 2026
Kind
B2
Art Unit
3771
USPC
623/2.11
Abstract

Apparatus and methods are described including placing a valve frame within a subject's heart. The valve frame is configured to support the prosthetic valve within the native atrio-ventricular valve and includes a valve frame body having atrial and ventricular parts and at least one arm that is configured to extend from the ventricular part. The arm is deployed among chords of the native atrio-ventricular valve and is rotated, such as to pull the native atrio-ventricular valve radially inward toward the valve frame and twist the native atrio-ventricular valve around the valve frame, by recruiting and deflecting at least a portion of the chords. The frame body of the valve frame traps the native valve leaflets in a partially closed and twisted configuration by radially expanding, to thereby at least partially seal a space between the native atrio-ventricular valve and the prosthetic valve. Other applications are also described.

Claims (35)

1 . An apparatus for use with a prosthetic valve that is configured to be deployed within a native atrio-ventricular valve of a heart of a subject, the native atrio-ventricular valve including a valve annulus, valve leaflets, and chords, the apparatus comprising:

a valve frame configured to support the prosthetic valve within the native atrio-ventricular valve, the valve frame comprising:

a frame body comprising:

an atrial part configured to be positioned, when the valve frame is deployed, such that at least a portion of the atrial part is disposed on an atrial side of the native atrio-ventricular valve; and

a ventricular part configured to be positioned, when the valve frame is deployed, such that at least a portion of the ventricular part is disposed within a ventricle of the subject; and

at least one arm configured to extend from the ventricular part of the frame body axially toward the atrial part, the at least one arm being configured to deploy among the chords of the native atrio-ventricular valve, and the at least one arm being configured such that when the at least one arm is deployed among the chords and is rotated, the at least one arm pulls the native atrio-ventricular valve radially inward toward the valve frame and twists the native atrio-ventricular valve around the valve frame, by recruiting and deflecting at least a portion of the chords,

the frame body of the valve frame being configured to trap the native valve leaflets between the atrial part and the at least one arm in a partially closed and twisted configuration by the atrial part radially expanding against the at least one arm, to thereby at least partially seal a space between the native atrio-ventricular valve and the prosthetic valve.

2 . The apparatus according to claim 1 , wherein the valve frame comprises a protruding member shaped to protrude from the at least one arm, and configured to bar the portion of the chords that are recruited by the at least one arm from exiting the at least one arm.

3 . The apparatus according to claim 1 , wherein the native atrio-ventricular valve includes a mitral valve, and the valve frame is configured to support the prosthetic valve within the native mitral valve.

4 . The apparatus according to claim 1 , wherein the atrial part comprises a cylindrical portion that is configured to extend through an annular level of the native atrio-ventricular valve, and wherein the cylindrical portion of the atrial part is configured to radially expand toward the at least one arm, such as to trap the native valve leaflets between the cylindrical portion of atrial part and the at least one arm.

5 . The apparatus according to claim 1 , wherein:

the at least one arm is configured to twist the leaflets of the native valve, such that the leaflets of the native valve are shaped into overlapping configurations with respect to each other, and

the frame body of the valve frame is configured to seal the space between the native atrio-ventricular valve and the prosthetic valve by trapping the leaflets of the native valve in the overlapping configurations with respect to each other.

6 . The apparatus according to claim 5 , wherein the at least one arm is configured to seal commissures between the leaflets of the native atrio-ventricular valve by the twisting the leaflets of the native valve into the overlapping configurations with respect to each other.

7 . The apparatus according to claim 1 , wherein the at least one arm is configured to deploy among the chords of the native atrio-ventricular valve to a distance sufficient to recruit and deflect at least primary and secondary chords of the native atrio-ventricular valve.

8 . The apparatus according to claim 7 , wherein the at least one arm is configured to deploy among the chords of the native atrio-ventricular valve to a distance sufficient to further recruit and deflect tertiary chords of the native atrio-ventricular valve.

9 . An apparatus for use with a prosthetic valve that is configured to be deployed within a native atrio-ventricular valve of a heart of a subject, the native atrio-ventricular valve including a valve annulus, valve leaflets, and chords, the apparatus comprising:

a valve frame configured to support the prosthetic valve within the native atrio-ventricular valve, the valve frame comprising:

a frame body comprising:

an atrial part configured to be positioned, when the valve frame is deployed, such that at least a portion of the atrial part is disposed on an atrial side of the native atrio-ventricular valve; and

a ventricular part configured to be positioned, when the valve frame is deployed, such that at least a portion of the ventricular part is disposed within a ventricle of the subject; and

at least one arm configured to extend from the ventricular part of the frame body, the at least one arm being configured to deploy among the chords of the native atrio-ventricular valve, and the at least one arm being configured such that when the at least one arm is deployed among the chords and is rotated, the at least one arm pulls the native atrio-ventricular valve radially inward toward the valve frame and twists the native atrio-ventricular valve around the valve frame, by recruiting and deflecting at least a portion of the chords,

the frame body of the valve frame being configured to trap the native valve leaflets in a partially closed and twisted configuration by radially expanding, to thereby at least partially seal a space between the native atrio-ventricular valve and the prosthetic valve, wherein:

the ventricular part of the valve frame has radially-compressed and radially-expanded states; and

the at least one arm is configured to become deployed among the chords of native valve, even when the ventricular part of the valve frame is in its radially-compressed state.

10 . The apparatus according to claim 9 , wherein the valve frame comprises a protruding member shaped to protrude from the at least one arm, and configured to bar the portion of the chords that are recruited by the at least one arm from exiting the at least one arm.

11 . The apparatus according to claim 9 , wherein the native atrio-ventricular valve includes a mitral valve, and the valve frame is configured to support the prosthetic valve within the native mitral valve.

12 . The apparatus according to claim 9 , wherein the frame body of the valve frame is configured to trap the native valve leaflets in the partially closed and twisted configuration by the atrial part radially expanding against the at least one arm, such as to trap the native valve leaflets between the atrial part and the at least one arm.

13 . The apparatus according to claim 12 , wherein the atrial part comprises a cylindrical portion that is configured to extend through an annular level of the native atrio-ventricular valve, and wherein the cylindrical portion of the atrial part is configured to radially expand toward the at least one arm, such as to trap the native valve leaflets between the cylindrical portion of atrial part and the at least one arm.

14 . The apparatus according to claim 9 , wherein:

the at least one arm is configured to twist the leaflets of the native valve, such that the leaflets of the native valve are shaped into overlapping configurations with respect to each other, and

the frame body of the valve frame is configured to seal the space between the native atrio-ventricular valve and the prosthetic valve by trapping the leaflets of the native valve in the overlapping configurations with respect to each other.

15 . The apparatus according to claim 14 , wherein the at least one arm is configured to seal commissures between the leaflets of the native atrio-ventricular valve by the twisting the leaflets of the native valve into the overlapping configurations with respect to each other.

16 . The apparatus according to claim 9 , wherein the at least one arm is configured to deploy among the chords of the native atrio-ventricular valve to a distance sufficient to recruit and deflect at least primary and secondary chords of the native atrio-ventricular valve.

17 . The apparatus according to claim 16 , wherein the at least one arm is configured to deploy among the chords of the native atrio-ventricular valve to a distance sufficient to further recruit and deflect tertiary chords of the native atrio-ventricular valve.

Assignments (4)
CHANGE OF NAME Recorded Oct 7, 2024
From: TEL HASHOMER MEDICAL RESEARCH, INFRASTRUCTURE AND SERVICES LTD.
To: SHEBA IMPACT LTD.
Reel/Frame 069114/0139 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 26, 2024
From: HARARI, BOAZ; MEIRI, ODED; ROZITSKY, LICHEN
To: MITRALHEAL LTD.
Reel/Frame 068397/0542 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 26, 2024
From: RAANANI, EHUD; ORLOV, BORIS
To: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
Reel/Frame 068397/0679 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 26, 2024
From: MITRALHEAL LTD.
To: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
Reel/Frame 068792/0568 →
Continuity (6)
Continuation 17932014 · Sep 14, 2022
Continuation 17349152 · Jun 16, 2021
Continuation 16374240 · Apr 3, 2019
Continuation 14402387 · May 20, 2013
Provisional Application 61649319 · May 20, 2012
Related Publication 20240415644A1 · Dec 19, 2024
References Cited (317)
US 6270520B1 · Inoue · 2001 [cited by applicant]
US 7018408B2 · Bailey et al. · 2006 [cited by applicant]
US 7621948B2 · Herrmann et al. · 2009 [cited by applicant]
US 7748389B2 · Salahieh et al. · 2010 [cited by applicant]
US 7753949B2 · Lamphere et al. · 2010 [cited by applicant]
US 8070802B2 · Lamphere et al. · 2011 [cited by applicant]
US 8870950B2 · Hacohen · 2014 [cited by applicant]
US 9364326B2 · Yaron · 2016 [cited by applicant]
US 9700412B2 · Yaron et al. · 2017 [cited by applicant]
US 9949830B2 · Solem · 2018 [cited by applicant]
US 10105217B2 · Keränen · 2018 [cited by applicant]
US 10130471B2 · Keränen et al. · 2018 [cited by applicant]
US 10238489B2 · Conklin · 2019 [cited by applicant]
US 10292816B2 · Raanani et al. · 2019 [cited by applicant]
US 10292850B2 · Vad et al. · 2019 [cited by applicant]
US 10500038B1 · Orlov et al. · 2019 [cited by applicant]
US 11065114B2 · Raanani et al. · 2021 [cited by applicant]
US 11583394B2 · Orlov et al. · 2023 [cited by applicant]
US 11779459B2 · Raanani et al. · 2023 [cited by applicant]
US 20020065554A1 · Streeter · 2002 [cited by applicant]
US 20030014104A1 · Cribier · 2003 [cited by applicant]
US 20030083742A1 · Spence et al. · 2003 [cited by applicant]
US 20040138745A1 · Macoviak et al. · 2004 [cited by applicant]
US 20050165479A1 · Drews et al. · 2005 [cited by applicant]
US 20060195134A1 · Crittenden · 2006 [cited by applicant]
US 20060195184A1 · Lane et al. · 2006 [cited by applicant]
US 20060241745A1 · Solem · 2006 [cited by applicant]
US 20070016288A1 · Gurskis et al. · 2007 [cited by applicant]
US 20070050020A1 · Spence · 2007 [cited by applicant]
US 20070260305A1 · Drews et al. · 2007 [cited by applicant]
US 20070293942A1 · Mirzaee · 2007 [cited by applicant]
US 20080039935A1 · Buch et al. · 2008 [cited by applicant]
US 20090192585A1 · Bloom et al. · 2009 [cited by applicant]
US 20090192586A1 · Tabor et al. · 2009 [cited by applicant]
US 20090198324A1 · Orlov · 2009 [cited by applicant]
US 20090281618A1 · Hill et al. · 2009 [cited by applicant]
US 20100022640A1 · Stoutamire · 2010 [cited by applicant]
US 20100030330A1 · Bobo et al. · 2010 [cited by applicant]
US 20100042208A1 · Herrmann et al. · 2010 [cited by applicant]
US 20100049313A1 · Alon et al. · 2010 [cited by applicant]
US 20100082094A1 · Quadri et al. · 2010 [cited by applicant]
US 20100249923A1 · Alkhatib et al. · 2010 [cited by applicant]
US 20100331971A1 · Keraenen et al. · 2010 [cited by applicant]
US 20110029072A1 · Gabbay · 2011 [cited by applicant]
US 20110137397A1 · Chau et al. · 2011 [cited by applicant]
US 20110137410A1 · Hacohen · 2011 [cited by examiner]
US 20110218620A1 · Meiri et al. · 2011 [cited by applicant]
US 20110224785A1 · Hacohen · 2011 [cited by applicant]
US 20110264208A1 · Duffy et al. · 2011 [cited by applicant]
US 20110319989A1 · Lane et al. · 2011 [cited by applicant]
US 20120010461A1 · Goldfarb et al. · 2012 [cited by applicant]
US 20120022633A1 · Olson et al. · 2012 [cited by applicant]
US 20120022639A1 · Hacohen et al. · 2012 [cited by applicant]
US 20120022640A1 · Gross et al. · 2012 [cited by applicant]
US 20120101571A1 · Thambar et al. · 2012 [cited by applicant]
US 20130035759A1 · Gross et al. · 2013 [cited by applicant]
US 20130079873A1 · Migliazza et al. · 2013 [cited by applicant]
US 20130166022A1 · Conklin · 2013 [cited by applicant]
US 20130190861A1 · Chau et al. · 2013 [cited by applicant]
US 20140031928A1 · Murphy et al. · 2014 [cited by applicant]
US 20140088695A1 · Figulla et al. · 2014 [cited by applicant]
US 20140088696A1 · Figulla et al. · 2014 [cited by applicant]
US 20140194975A1 · Quill et al. · 2014 [cited by applicant]
US 20140200662A1 · Eftel et al. · 2014 [cited by applicant]
US 20140222136A1 · Geist et al. · 2014 [cited by applicant]
US 20140222142A1 · Kovalsky et al. · 2014 [cited by applicant]
US 20140324164A1 · Gross et al. · 2014 [cited by applicant]
US 20140379074A1 · Spence et al. · 2014 [cited by applicant]
US 20150045880A1 · Hacohen · 2015 [cited by applicant]
US 20150127093A1 · Hosmer et al. · 2015 [cited by applicant]
US 20150164640A1 · McLean et al. · 2015 [cited by applicant]
US 20150173897A1 · Raanani et al. · 2015 [cited by applicant]
US 20150265400A1 · Eidenschink et al. · 2015 [cited by applicant]
US 20150351903A1 · Morriss et al. · 2015 [cited by applicant]
US 20150351908A1 · Kernen et al. · 2015 [cited by applicant]
US 20150359628A1 · Keränen · 2015 [cited by applicant]
US 20150374493A1 · Yaron et al. · 2015 [cited by applicant]
US 20160045306A1 · Agrawal et al. · 2016 [cited by applicant]
US 20160095705A1 · Keränen et al. · 2016 [cited by applicant]
US 20160310268A1 · Oba et al. · 2016 [cited by applicant]
US 20170128199A1 · Gurovich et al. · 2017 [cited by applicant]
US 20170143478A1 · Schwartz et al. · 2017 [cited by applicant]
US 20170216023A1 · Lane et al. · 2017 [cited by applicant]
US 20170281338A1 · Quill et al. · 2017 [cited by applicant]
US 20180008404A1 · Tamir · 2018 [cited by applicant]
US 20180014932A1 · Hammer et al. · 2018 [cited by applicant]
US 20180125651A1 · Nasr · 2018 [cited by applicant]
US 20180177594A1 · Patel et al. · 2018 [cited by applicant]
US 20180206992A1 · Brown · 2018 [cited by applicant]
US 20180303609A1 · Kenny et al. · 2018 [cited by applicant]
US 20180311037A1 · Morriss et al. · 2018 [cited by applicant]
US 20180318079A1 · Patel et al. · 2018 [cited by applicant]
US 20190083245A1 · Hariton et al. · 2019 [cited by applicant]
US 20190110893A1 · Haarer et al. · 2019 [cited by applicant]
US 20190125534A1 · Arcaro et al. · 2019 [cited by applicant]
US 20190142590A1 · Yeo et al. · 2019 [cited by applicant]
US 20190231520A1 · Desrosiers et al. · 2019 [cited by applicant]
US 20190231522A1 · Raanani et al. · 2019 [cited by applicant]
US 20200100898A1 · Vola et al. · 2020 [cited by applicant]
US 20200121454A1 · Spence · 2020 [cited by applicant]
US 20200138569A1 · Basude et al. · 2020 [cited by applicant]
US 20200179109A1 · Reimer et al. · 2020 [cited by applicant]
US 20200197175A1 · Chang et al. · 2020 [cited by applicant]
US 20220010634A1 · Posa · 2022 [cited by applicant]
US 20220015896A1 · Agian et al. · 2022 [cited by applicant]
US 20220015900A1 · Agian et al. · 2022 [cited by applicant]
US 20220015905A1 · Raanani et al. · 2022 [cited by applicant]
US 20220296370A1 · Agian et al. · 2022 [cited by applicant]
US 20230000622A1 · Raanani et al. · 2023 [cited by applicant]
US 20230172707A1 · Orlov et al. · 2023 [cited by applicant]
US 20230270549A1 · Guidotti et al. · 2023 [cited by applicant]
US 20230372099A1 · Orlov · 2023 [cited by applicant]
US 20240148498A1 · Quadri et al. · 2024 [cited by applicant]
US 20240207045A1 · Orlov et al. · 2024 [cited by applicant]
US 20250268704A1 · Chin · 2025 [cited by applicant]
AU 2014202116A1 · 2014 [cited by applicant]
CA 2606101A1 · 2006 [cited by applicant]
CA 2898991A1 · 2014 [cited by applicant]
CN 101180010A · 2008 [cited by applicant]
CN 102292053A · 2011 [cited by applicant]
CN 102438546A · 2012 [cited by applicant]
CN 103517688A · 2014 [cited by applicant]
CN 104684505A · 2015 [cited by applicant]
CN 104994812A · 2015 [cited by applicant]
DE 102006052564 · 2007 [cited by applicant]
EP 1850796B1 · 2015 [cited by applicant]
EP 3315094A1 · 2018 [cited by applicant]
EP 3399947A1 · 2018 [cited by applicant]
EP 2948102B1 · 2019 [cited by applicant]
EP 2852354B1 · 2020 [cited by applicant]
JP 2008536592A · 2008 [cited by applicant]
JP 2011509806A · 2011 [cited by applicant]
JP 2012500665A · 2012 [cited by applicant]
JP 2012521222A · 2012 [cited by applicant]
JP 2014168694A · 2014 [cited by applicant]
JP 2015517376A · 2015 [cited by applicant]
JP 2016504134A · 2016 [cited by applicant]
JP 2018501001A · 2018 [cited by applicant]
JP 2019500965A · 2019 [cited by applicant]
JP 7051736B2 · 2022 [cited by applicant]
WO 0060995A2 · 2000 [cited by applicant]
WO 2004032724A2 · 2004 [cited by applicant]
WO 2005087140A1 · 2005 [cited by applicant]
WO 2006116558A2 · 2006 [cited by applicant]
WO 2007135101A1 · 2007 [cited by applicant]
WO 2009134701A2 · 2009 [cited by applicant]
WO 2010108079A1 · 2010 [cited by applicant]
WO 2012004679A2 · 2012 [cited by applicant]
WO 2012095116A1 · 2012 [cited by applicant]
WO 2013001339A2 · 2013 [cited by applicant]
WO 2013028387A2 · 2013 [cited by applicant]
WO 2013175468A2 · 2013 [cited by applicant]
WO 2014114795A1 · 2014 [cited by applicant]
WO 2015198125A1 · 2015 [cited by applicant]
WO 2018109329A1 · 2018 [cited by applicant]
WO 2018112429A1 · 2018 [cited by applicant]
WO 2020092096A2 · 2020 [cited by applicant]
WO 2020100050A1 · 2020 [cited by applicant]
WO 2021021368A1 · 2021 [cited by applicant]
WO 2021028867A1 · 2021 [cited by applicant]
WO 2021195090A1 · 2021 [cited by applicant]
WO 2022090881A1 · 2022 [cited by applicant]
WO 2022090882A1 · 2022 [cited by applicant]
WO 2022234468A1 · 2022 [cited by applicant]
WO 2022264082A1 · 2022 [cited by applicant]
WO 2023228028A1 · 2023 [cited by applicant]
WO 2024057226A1 · 2024 [cited by applicant]
International Search Report and Written Opinion from International Application No. PCT/IB2024/052304 mailed Jun. 17, 2024. [cited by applicant]
Issue Notification for U.S. Appl. No. 17/932,014 mailed Sep. 4, 2024. [cited by applicant]
Notice of Allowance for U.S. Appl. No. 18/103,671 mailed Sep. 28, 2024. [cited by applicant]
Office Action for Israel Application No. 290306 mailed Jul. 7, 2024. [cited by applicant]
Examination Report for Indian Application No. 202247005897 mailed Dec. 11, 2024,. [cited by applicant]
Issue Notification for U.S. Appl. No. 17/488,628 mailed Oct. 23, 2024,. [cited by applicant]
Issue Notification for U.S. Appl. No. 18/103,671 mailed Jan. 8, 2025,. [cited by applicant]
Notice of Allowance for U.S. Appl. No. 17/292,987 mailed Mar. 5, 2025,. [cited by applicant]
Notice of Allowance for U.S. Appl. No. 17/488,623 mailed Jan. 6, 2025,. [cited by applicant]
Office Action for Chinese Application No. 201980082413.X mailed Sep. 26, 2024,. [cited by applicant]
Office Action for Israel Application No. 283093 mailed Jan. 16, 2025,. [cited by applicant]
U.S. Appl. No. 18/867,696, filed Nov. 20, 2024,. [cited by applicant]
U.S. Appl. No. 18/994,876, filed Jan. 15, 2025,. [cited by applicant]
U.S. Appl. No. 18/999,207, filed Dec. 23, 2024. [cited by applicant]
U.S. Appl. No. 63/344,590, filed May 22, 2022. [cited by applicant]
U.S. Appl. No. 63/405,966, filed Sep. 13, 2022. [cited by applicant]
Advisory Action for U.S. Appl. No. 14/402,387 mailed Mar. 1, 2018. [cited by applicant]
Applicant-Initiated Interview Summary for U.S. Appl. No. 14/402,387 mailed Dec. 28, 2017. [cited by applicant]
Applicant-Initiated Interview Summary for U.S. Appl. No. 14/402,387 mailed May 25, 2017. [cited by applicant]
Communication Relating to the Results of the Partial International Search from International Application No. PCT/IL2013/050432 mailed Nov. 18, 2013. [cited by applicant]
Corrected Notice of Allowability for U.S. Appl. No. 14/402,387 mailed Mar. 20, 2019. [cited by applicant]
Examination Report for Australian Application No. 2013264730 mailed Dec. 20, 2017. [cited by applicant]
Examination Report for Australian Application No. 2013264730 mailed Jan. 13, 2017. [cited by applicant]
Examination Report for Australian Application No. 2018202951 mailed Dec. 6, 2018. [cited by applicant]
Examination Report for Australian Application No. 2019250140 mailed Oct. 19, 2020. [cited by applicant]
Examination Report for European Application No. 13732633.6 mailed Aug. 8, 2019. [cited by applicant]
Examination Report for European Application No. 13732633.6 mailed Jan. 8, 2018. [cited by applicant]
Examination Report for European Application No. 20760551.0 mailed Apr. 7, 2022. [cited by applicant]
Examination Report for European Application No. 21801644.2 mailed May 2, 2024. [cited by applicant]
Examination Report for Indian Application No. 20217021772 mailed Jan. 11, 2023. [cited by applicant]
Examination Report for Indian Application No. 2424/MUMNP/2014 mailed Aug. 31, 2020. [cited by applicant]
Extended European Search Report for European Application No. 23162937.9 mailed Jun. 21, 2023. [cited by applicant]
Final Office Action for U.S. Appl. No. 13/083,643 mailed Mar. 5, 2014. [cited by applicant]
Final Office Action for U.S. Appl. No. 13/475,994 mailed Jan. 10, 2017. [cited by applicant]
Final Office Action for U.S. Appl. No. 13/475,994 mailed Jun. 10, 2015. [cited by applicant]
Final Office Action for U.S. Appl. No. 13/475,994 mailed Jun. 8, 2018. [cited by applicant]
Final Office Action for U.S. Appl. No. 14/402,387 mailed Oct. 2, 2017. [cited by applicant]
Final Office Action for U.S. Appl. No. 17/488,623 mailed May 30, 2024. [cited by applicant]
Final Office Action for U.S. Appl. No. 17/488,628 mailed Jul. 31, 2024. [cited by applicant]
Final Office Action for U.S. Appl. No. 18/103,671 mailed Jul. 29, 2024. [cited by applicant]
Hearing Notice for Indian Application No. 2424/MUMNP/2014 mailed Jan. 3, 2023. [cited by applicant]
International Preliminary Report on Patentability from International Application No. PCT/IL2013/050432 mailed Dec. 4, 2014. [cited by applicant]
International Search Report and Written Opinion from International Application No. PCT/IB2019/059734 mailed Feb. 6, 2020. [cited by applicant]
International Search Report and Written Opinion from International Application No. PCT/IB2020/057636 mailed Oct. 29, 2020. [cited by applicant]
International Search Report and Written Opinion from International Application No. PCT/IB2021/059798 mailed Jan. 24, 2022. [cited by applicant]
International Search Report and Written Opinion from International Application No. PCT/IB2021/059799 mailed Jan. 25, 2022. [cited by applicant]
International Search Report and Written Opinion from International Application No. PCT/IB2022/054099 mailed Sep. 12, 2022. [cited by applicant]
International Search Report and Written Opinion from International Application No. PCT/IB2022/055593 mailed Nov. 14, 2022. [cited by applicant]
International Search Report and Written Opinion from International Application No. PCT/IB2023/055160 mailed Jul. 28, 2023. [cited by applicant]
International Search Report and Written Opinion from International Application No. PCT/IB2023/059084 mailed Feb. 12, 2024. [cited by applicant]
International Search Report and Written Opinion from International Application No. PCT/IL2013/050432 dated Feb. 26, 2014. [cited by applicant]
International Search Report and Written Opinion from International Application No. PCT/IL2013/050432 mailed Feb. 26, 2014. [cited by applicant]
Invitation to Pay Additional Fees for International Application No. PCT/IB2022/054099 mailed Jul. 20, 2022. [cited by applicant]
Invitation to Pay Additional Fees for International Application No. PCT/IB2022/055593 mailed Sep. 23, 2022. [cited by applicant]
Invitation to Pay Additional Fees for International Application No. PCT/IB2023/059084 mailed Dec. 22, 2023. [cited by applicant]
Issue Notification for U.S. Appl. No. 13/475,994 mailed Nov. 20, 2019. [cited by applicant]
Issue Notification for U.S. Appl. No. 14/402,387 mailed May 1, 2019. [cited by applicant]
Issue Notification for U.S. Appl. No. 16/374,240 mailed Jun. 30, 2021. [cited by applicant]
Issue Notification for U.S. Appl. No. 16/655,656 mailed Feb. 1, 2023. [cited by applicant]
Issue Notification for U.S. Appl. No. 17/349,152 mailed Sep. 20, 2023. [cited by applicant]
Non-Final Office Action for U.S. Appl. No. 13/475,994 mailed Apr. 1, 2016. [cited by applicant]
Non-Final Office Action for U.S. Appl. No. 13/475,994 mailed Dec. 28, 2018. [cited by applicant]
Non-Final Office Action for U.S. Appl. No. 13/475,994 mailed Oct. 1, 2014. [cited by applicant]
Non-Final Office Action for U.S. Appl. No. 13/475,994 mailed Sep. 11, 2017. [cited by applicant]
Non-Final Office Action for U.S. Appl. No. 14/402,387 mailed Dec. 23, 2016. [cited by applicant]
Non-Final Office Action for U.S. Appl. No. 14/402,387 mailed Sep. 20, 2018. [cited by applicant]
Non-Final Office Action for U.S. Appl. No. 16/655,656 mailed Jun. 17, 2022. [cited by applicant]
Non-Final Office Action for U.S. Appl. No. 17/263,776 mailed Oct. 25, 2023. [cited by applicant]
Non-Final Office Action for U.S. Appl. No. 17/292,987 mailed May 21, 2024. [cited by applicant]
Non-Final Office Action for U.S. Appl. No. 17/488,623 mailed Jul. 31, 2024. [cited by applicant]
Non-Final Office Action for U.S. Appl. No. 17/488,623 mailed Oct. 26, 2023. [cited by applicant]
Non-Final Office Action for U.S. Appl. No. 17/488,628 mailed May 31, 2024. [cited by applicant]
Non-Final Office Action for U.S. Appl. No. 17/488,628 mailed Oct. 26, 2023. [cited by applicant]
Non-Final Office Action for U.S. Appl. No. 18/103,671 mailed Apr. 2, 2024. [cited by applicant]
Notice of Allowance for U.S. Appl. No. 13/475,994 mailed Jul. 22, 2019. [cited by applicant]
Notice of Allowance for U.S. Appl. No. 14/402,387 mailed Apr. 30, 2019. [cited by applicant]
Notice of Allowance for U.S. Appl. No. 14/402,387 mailed Jan. 30, 2019. [cited by applicant]
Notice of Allowance for U.S. Appl. No. 16/374,240 mailed Mar. 16, 2021. [cited by applicant]
Notice of Allowance for U.S. Appl. No. 16/655,656 mailed Oct. 25, 2022. [cited by applicant]
Notice of Allowance for U.S. Appl. No. 17/263,776 mailed Apr. 9, 2024. [cited by applicant]
Notice of Allowance for U.S. Application No. 17/349, 152 mailed May 24, 2023. [cited by applicant]
Notice of Allowance for U.S. Appl. No. 17/932,014 mailed May 22, 2024. [cited by applicant]
Notice of Amendment and English Translation for Chinese Application No. 201710425696.6 mailed Jun. 23, 2017. [cited by applicant]
Office Action and Search Report for Chinese Application No. 201380038199.0 mailed Sep. 7, 2016. [cited by applicant]
Office Action for Australian Application No. 2018202951 mailed Apr. 1, 2019. [cited by applicant]
Office Action for Canadian Application No. 2,874,208 mailed Aug. 2, 2019. [cited by applicant]
Office Action for Canadian Application No. 2,874,208 mailed Feb. 19, 2019. [cited by applicant]
Office Action for Canadian Application No. 3, 149,527 mailed Mar. 6, 2023. [cited by applicant]
Office Action for Chinese Application No. 201380038199.0 mailed Dec. 14, 2016. [cited by applicant]
Office Action for Chinese Application No. 201380038199.0 mailed Dec. 3, 2015. [cited by applicant]
Office Action for Chinese Application No. 201710425696.6 mailed May 19, 2020. [cited by applicant]
Office Action for Chinese Application No. 201710425696.6 mailed Nov. 4, 2019. [cited by applicant]
Office Action for Chinese Application No. 201980082413 mailed Jan. 31, 2024. [cited by applicant]
Office Action for Israel Application No. 283093 mailed Feb. 18, 2024. [cited by applicant]
Office Action for Japanese Application No. 2015-513347 mailed Feb. 14, 2017. [cited by applicant]
Office Action for Japanese Application No. 2017-184962 mailed Jul. 31, 2018. [cited by applicant]
Office Action for Japanese Application No. 2019/032726 mailed Feb. 18, 2020. [cited by applicant]
Office Action for Japanese Application No. 2019/032726 mailed Jan. 19, 2021. [cited by applicant]
Office Action for Japanese Application No. 2019/032726 mailed Nov. 19, 2021. [cited by applicant]
Office Action for Japanese Application No. 2021-525788 mailed Mar. 11, 2024. [cited by applicant]
Office Action for Japanese Application No. 2021-525788 mailed Nov. 1, 2023. [cited by applicant]
Office Action for Japanese Application No. 2022-508890 mailed Apr. 9, 2024. [cited by applicant]
Restriction Requirement for U.S. Appl. No. 13/475,994 mailed Mar. 11, 2014. [cited by applicant]
U.S. Appl. No. 12/582,986, filed Oct. 21, 2009. [cited by applicant]
U.S. Appl. No. 13/475,994, filed May 20, 2012. [cited by applicant]
U.S. Appl. No. 14/402,387, filed Nov. 20, 2014. [cited by applicant]
U.S. Appl. No. 16/374,240, filed Apr. 3, 2019. [cited by applicant]
U.S. Appl. No. 16/655,656, filed Oct. 17, 2019. [cited by applicant]
U.S. Appl. No. 17/263,776, filed Jan. 27, 2021. [cited by applicant]
U.S. Appl. No. 17/349,152 filed Jun. 16, 2021. [cited by applicant]
U.S. Appl. No. 17/488,623, filed Sep. 29, 2021. [cited by applicant]
U.S. Appl. No. 17/488,628, filed Sep. 29, 2021. [cited by applicant]
U.S. Appl. No. 17/932,014, filed Sep. 14, 2022. [cited by applicant]
U.S. Appl. No. 18/103,671, filed Jan. 31, 2023. [cited by applicant]
U.S. Appl. No. 18/248,394, filed Apr. 10, 2023. [cited by applicant]
U.S. Appl. No. 61/488,180 filed May 20, 2011. [cited by applicant]
U.S. Appl. No. 61/649,319, filed May 20, 2012. [cited by applicant]
U.S. Appl. No. 62/767,018, filed Nov. 14, 2018. [cited by applicant]
U.S. Appl. No. 62/886,366, filed Aug. 14, 2019. [cited by applicant]
U.S. Appl. No. 63/106,000, filed Oct. 27, 2020. [cited by applicant]
U.S. Appl. No. 63/106,034, filed Oct. 27, 2020. [cited by applicant]
U.S. Appl. No. 63/184,403, filed May 5, 2021. [cited by applicant]
U.S. Appl. No. 63/184,427, filed May 5, 2021. [cited by applicant]
U.S. Appl. No. 63/211,602, filed Jun. 17, 2021. [cited by applicant]
Communication Pursuant to Article 94(3) EPC for European Application No. 21801644.2 mailed Apr. 24, 2025. [cited by applicant]
Corrected Notice of Allowability for U.S. Appl. No. 17/906,332 mailed Feb. 10, 2026. [cited by applicant]
Corrected Notice of Allowability for U.S. Appl. No. 17/906,332 mailed Mar. 10, 2026. [cited by applicant]
Corrected Notice of Allowability for U.S. Appl. No. 17/906,332 mailed Mar. 2, 2026. [cited by applicant]
Examination Report for European Application No. 19808898.1 mailed Sep. 10, 2025. [cited by applicant]
Examination Report for European Application No. 21801644.2 mailed Dec. 19, 2025. [cited by applicant]
Extended European Search Report for European Application No. 22728269.6 mailed Mar. 17, 2025. [cited by applicant]
International Search Report and Written Opinion from International Application No. PCT/IB2025/056499 mailed Nov. 28, 2025. [cited by applicant]
Invitation to Pay Additional Fees for International Application No. PCT/IB2025/056499 mailed Oct. 7, 2025. [cited by applicant]
Issue Notification for U.S. Appl. No. 17/488,623 mailed Aug. 13, 2025. [cited by applicant]
Non-Final Office Action for U.S. Appl. No. 17/906,332 mailed Sep. 25, 2025. [cited by applicant]
Non-Final Office Action for U.S. Appl. No. 17/906,388 mailed Jun. 4, 2025. [cited by applicant]
Non-Final Office Action for U.S. Appl. No. 18/248,220 mailed Mar. 9, 2026. [cited by applicant]
Non-Final Office Action for U.S. Appl. No. 18/248,394 mailed Nov. 7, 2025. [cited by applicant]
Notice Before Refusal for Israel Application No. 283093 mailed Jan. 4, 2026. [cited by applicant]
Notice of Allowance for U.S. Appl. No. 17/488,623 mailed Apr. 24, 2025. [cited by applicant]
Notice of Allowance for U.S. Appl. No. 17/906,332 mailed Feb. 2, 2026. [cited by applicant]
Notice of Allowance for U.S. Appl. No. 17/906,388 mailed Dec. 9, 2025. [cited by applicant]
Office Action for Chinese Application No. 202080062891.7 mailed Mar. 5, 2025. [cited by applicant]
Office Action for Chinese Application No. 202180072661.3 mailed Feb. 9, 2026. [cited by applicant]
Office Action for Israel Application No. 283093 mailed Jul. 20, 2025. [cited by applicant]
Office Action for Japanese Application No. 2023-566611 mailed Feb. 20, 2026. [cited by applicant]
Office Action for Japanese Application No. 2024-157831 mailed Nov. 20, 2025. [cited by applicant]
Office Action for Japanese Application No. 2024-192559 mailed Dec. 8, 2025. [cited by applicant]
Restriction Requirement for U.S. Appl. No. 18/248,220 mailed Dec. 5, 2025. [cited by applicant]
U.S. Appl. No. 17/292,987, filed May 11, 2021. [cited by applicant]