Granted Patent B2

US 12,722,012 · App. 18/307,585 · Granted Sep 1, 2026

Inventors: Kristin N. Hageman (Dayton, MN); Scott R. Stanslaski (Shoreview, MN); Erik J. Peterson (Fridley, MN); Rene A. Molina (Maple Grove, MN); Paul H. Stypulkowski (North Oaks, MN); David A. Dinsmoor (North Oaks, MN); Leonid M. Litvak (Beit Shemesh, IL)

Assignee: Medtronic, Inc.

A61N1/36139A61N1/025

Abstract

Claims (55)

1 . A system for closed-loop therapy, the system comprising:

memory configured to store a first set of one or more parameters for a first set of one or more therapeutic electrical stimulation signals; and

processing circuitry coupled to the memory and configured to:

determine one or more local field potential (LFP) measurements of an LFP, wherein the LFP is of a first signal type that is intrinsically generated by a signal source within a brain of a patient;

cause delivery of one or more electrical stimulation signals;

determine one or more evoked signals that are evoked by delivery of respective ones of the one or more electrical stimulation signals, wherein the one or more evoked signals are of a second signal type that is different than the first signal type of the LFP;

determine a second set of one or more parameters for a second set of one or more therapeutic electrical stimulation signals based on the one or more evoked signals having the second signal type and the one or more LFP measurements of the LFP having the first signal type, wherein the second set of one or more parameters are updates to the first set of one or more parameters; and

cause delivery of the second set of the one or more therapeutic electrical stimulation signals.

2 . The system of claim 1 , wherein to determine the one or more LFP measurements, the processing circuitry is configured to determine that there is a change in the LFP measurements, and wherein to determine the one or more evoked signals, the processing circuitry is configured to determine the one or more evoked signals responsive to the determination that there is the change in the LFP measurements.

3 . The system of claim 2 , wherein the processing circuitry is configured to determine that there is the change in the LFP measurements during an instance where there is no delivery of therapeutic electrical stimulation signals.

4 . The system of claim 1 , wherein to determine the one or more LFP measurements, the processing circuitry is configured to determine that there is no change in the LFP measurements for a period of time, and wherein to determine the one or more evoked signals, the processing circuitry is configured to determine the one or more evoked signals responsive to the determination that there is no change in the LFP measurements for the period of time.

5 . The system of claim 1 , wherein to determine the one or more LFP measurements, the processing circuitry is configured to determine that the one or more LFP measurements are greater than or below a threshold signal level for a period of time, and wherein to determine the one or more evoked signals, the processing circuitry is configured to determine the one or more evoked signals responsive to the determination that the one or more LFP measurements are greater than or below the threshold signal level for the period of time.

6 . The system of claim 1 , wherein the processing circuitry is configured to determine that the one or more LFP measurements include artifacts, and wherein to determine the one or more evoked signals, the processing circuitry is configured to determine the one or more evoked signals responsive to the determination that the one or more LFP measurements include artifacts.

7 . The system of claim 1 , wherein the one or more LFP measurements comprise one or more current LFP measurements, wherein the processing circuitry is configured to retrieve from the memory information indicative of one or more target LFP measurements, and wherein to determine the one or more evoked signals, the processing circuitry is configured to:

compare the one or more current LFP measurements to the one or more target LFP measurements;

based on the one or more current LFP measurements deviating from the one or more target LFP by a threshold signal level, determine that the one or more evoked signals are to be determined; and

determine the one or more evoked signal responsive to the determination that the one or more evoked signals are to be determined.

8 . The system of claim 1 , further comprising sensing circuitry configured to sense the one or more LFP measurements during delivery of the first set of the one or more therapeutic electrical stimulation signals.

9 . The system of claim 1 , wherein to determine the one or more LFP measurements of the LFP, the processing circuitry is configured to:

utilize the one or more evoked signals to determine whether to trigger a determination of the one or more LFP measurements of the LFP; and

in response to determining to trigger the determination of the one or more LFP measurements of the LFP, determine the one or more LFP measurements.

10 . The system of claim 1 , further comprising an implantable medical device (IMD), wherein the IMD includes the processing circuitry.

11 . The system of claim 1 , further comprising a programmer, wherein the programmer includes the processing circuitry.

12 . The system of claim 1 , further comprising an implantable medical device (IMD) and a programmer, and wherein the processing circuitry is part of the IMD, the programmer, or both the IMD and the programmer.

13 . The system of claim 1 , wherein the one or more evoked signals are one or more evoked resonant neural activity signals.

14 . A method for closed-loop therapy, the method comprising:

storing a first set of one or more parameters for a first set of one or more therapeutic electrical stimulation signals;

determining one or more local field potential (LFP) measurements of an LFP, wherein the LFP is of a first signal type that is intrinsically generated by a signal source within a brain of a patient;

causing delivery of one or more electrical stimulation signals;

determining one or more evoked signals that are evoked by delivery of respective ones of the one or more electrical stimulation signals, wherein the one or more evoked signals are of a second signal type that is different than the first signal type of the LFP;

determining a second set of one or more parameters for a second set of one or more therapeutic electrical stimulation signals based on the one or more evoked signals having the second signal type and the one or more LFP measurements of the LFP having the first signal type, wherein the second set of one or more parameters are updates to the first set of one or more parameters; and

causing delivery of the second set of the one or more therapeutic electrical stimulation signals.

15 . The system of claim 1 , wherein a respective evoked signal of the one or more evoked signals is not present within the brain prior to delivery of a respective electrical stimulation signal that evoked the respective evoked signal.

16 . The method of claim 14 , wherein the one or more evoked signals are one or more evoked resonant neural activity signals.

17 . The method of claim 14 , wherein determining the one or more LFP measurements comprises determining that there is a change in the LFP measurements, and wherein determining the one or more evoked signals comprises determining the one or more evoked signals responsive to the determination that there is the change in the LFP measurements.

18 . The method of claim 17 , wherein determining that there is a change in the LFP measurements comprises determining that there is the change in the LFP measurements during an instance where there is no delivery of therapeutic electrical stimulation signals.

19 . The method of claim 14 , wherein determining the one or more LFP measurements comprises determining that there is no change in the LFP measurements for a period of time, and wherein determining the one or more evoked signals comprises determining the one or more evoked signals responsive to the determination that there is no change in the LFP measurements for the period of time.

20 . The method of claim 14 , wherein determining the one or more LFP measurements comprises determining that the one or more LFP measurements are greater than or below a threshold signal level for a period of time, and determining the one or more evoked signals comprises determining the one or more evoked signals responsive to the determination that the one or more LFP measurements are greater than or below the threshold signal level for the period of time.

21 . The method of claim 14 , further comprising determining that the one or more LFP measurements include artifacts, and wherein determining the one or more evoked signals comprises determining the one or more evoked signals responsive to the determination that the one or more LFP measurements include artifacts.

22 . The method of claim 14 , wherein the one or more LFP measurements comprise one or more current LFP measurements, the method further comprising retrieving from memory information indicative of one or more target LFP measurements, and wherein determining the one or more evoked signals comprises:

comparing the one or more current LFP measurements to the one or more target LFP measurements;

based on the one or more current LFP measurements deviating from the one or more target LFP by a threshold signal level, determining that the one or more evoked signals are to be determined; and

determining the one or more evoked signal responsive to the determination that the one or more evoked signals are to be determined.

23 . The method of claim 14 , further comprising sensing the one or more LFP measurements during delivery of the first set of the one or more therapeutic electrical stimulation signals.

24 . The method of claim 14 , wherein determining the one or more LFP measurements of the LFP comprises:

utilizing the one or more evoked signals to determine whether to trigger a determination of the one or more LFP measurements of the LFP; and

in response to determining to trigger the determination of the one or more LFP measurements of the LFP, determining the one or more LFP measurements.

25 . A non-transitory computer-readable storage medium storing instructions thereon that when executed cause one or more processors to:

store a first set of one or more parameters for a first set of one or more therapeutic electrical stimulation signals;

determine one or more local field potential (LFP) measurements of an LFP, wherein the LFP is of a first signal type that is intrinsically generated by a signal source within a brain of a patient;

cause delivery of one or more electrical stimulation signals;

determine one or more evoked resonant neural activity (ERNA) signals that are evoked by delivery of respective ones of the one or more electrical stimulation signals, wherein the ERNA signals are of a second type that is different than the first signal type of the LFP;

determine a second set of one or more parameters for a second set of one or more therapeutic electrical stimulation signals based on the one or more evoked signals having the second signal type and the one or more LFP measurements of the LFP having the first signal type, wherein the second set of one or more parameters are updates to the first set of one or more parameters; and

cause delivery of the second set of the one or more therapeutic electrical stimulation signals.

26 . The method of claim 14 , wherein a respective evoked signal of the one or more evoked signals is not present within the brain prior to delivery of a respective electrical stimulation signal that evoked the respective evoked signal.

Assignments (1)

Continuity (2)

References Cited (30)