IP Library Granted Patent US 12,723,079
Granted Patent B2
US 12,723,079 · App. 18/193,189 · Granted Sep 1, 2026

Anti-PD-1 antibodies

Inventors: Najmia Amirina (Cambridge, MA); Hareesh Chamarthi (Allston, MA); Maria Isabel Chiu (Newton Centre, MA); Daniel Doty (Arlington, MA); Bin Feng (Newton, MA); Aleksander Jonca (Boston, MA); Thomas McQuade (Cambridge, MA); Anhco Nguyen (Needham, MA); Sheila Ranganath (Arlington, MA); Hans Albert Felix Scheuplein (Arlington, MA); Vikki A. Spaulding (Acton, MA); Lei Wang (Braintree, MA); Jennifer Watkins-Yoon (Brighton, MA); Sri Sahitya Vadde (Ashland, MA)
Assignee: PD-I Acquisition Group, LLC
C07K16/2803A61K49/0058C07K16/2818A61K2039/505A61K2039/507A61K2039/54A61K2039/545C07K2317/24C07K2317/33C07K2317/34C07K2317/56C07K2317/565C07K2317/567C07K2317/73C07K2317/75C07K2317/76C07K2317/92
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Quick Facts
Patent No.
US 12,723,079
App. No.
18/193,189
Granted
Sep 1, 2026
Kind
B2
Abstract

Antibodies that bind to programmed cell death protein 1 (PD-1), compositions comprising such antibodies, and methods of making and using such antibodies are disclosed.

Claims (18)

1 . An isolated antibody that binds to programmed cell death protein 1 (PD-1), comprising a heavy chain variable region (HCVR) having complementarity determining regions (CDRs) 1-3 of SEQ ID NO: 25, and a light chain variable region (LCVR) having CDRs 1-3 of SEQ ID NO: 45.

2 . The antibody according to claim 1 , wherein the antibody comprises a HCVR having the sequence set forth in SEQ ID NO: 25 and a LCVR having the sequence set forth in SEQ ID NO: 45.

3 . The antibody according to claim 1 , comprising a humanized or human framework region.

4 . The antibody according to claim 1 , wherein the antibody binds to a sequence in PD-1 selected from the group consisting of SEQ ID NO: 74, SEQ ID NO: 75, SEQ ID NO: 76, SEQ ID NO: 77, SEQ ID NO: 78, SEQ ID NO: 79, SEQ ID NO: 80 and SEQ ID NO: 81, or a combination thereof.

5 . The antibody according to claim 1 , wherein the antibody is monoclonal.

6 . The antibody according to claim 1 , wherein the antibody is a PD-1 antagonist.

7 . An isolated nucleic acid comprising a nucleotide sequence encoding the antibody of claim 1 .

8 . An expression vector comprising the nucleic acid of claim 7 .

9 . A host cell transformed with an expression vector of claim 8 .

10 . A method of producing an antibody, the method comprising:

a) growing the host cell of claim 9 under conditions such that the host cell expresses the antibody; and

b) isolating the antibody.

11 . A method of treating a cancer in a mammal in need thereof, comprising administering an effective amount of the antibody according to claim 6 to the mammal.

12 . A method of diagnosing a PD-1-mediated adaptive immune resistance in a patient who has cancer, comprising:

contacting a tumor microenvironment in the patient with the antibody according to claim 1 labeled with a detectable moiety; and

detecting expression of PD-1 on CD8+ T cells within the tumor microenvironment.

13 . The method of claim 12 , further comprising detecting expression of PD-L1 in the tumor microenvironment.

14 . A method for increasing T cell effector function, comprising contacting a T cell with the antibody of claim 6 .

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 13, 2023
From: VADDE, SRI SAHITYA
To: ENUMERAL BIOMEDICAL HOLDINGS, INC.
Reel/Frame 064268/0388 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 13, 2023
From: AMIRINA, NAJMIA; CHAMARTHI, HAREESH; CHIU, MARIA ISABEL; FENG, BIN; JONCA, ALEKSANDER; MCQUADE, THOMAS; NGUYEN, ANHCO; RANGANATH, SHEILA; SPAULDING, VIKKI A.; WANG, LEI; WATKINS-YOON, JENNIFER; DOTY, DANIEL; SCHEUPLEIN, HANS ALBERT FELIX
To: ENUMERAL BIOMEDICAL HOLDINGS, INC.
Reel/Frame 064268/0441 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 13, 2023
From: ENUMERAL BIOMEDICAL HOLDINGS, INC.
To: PD-1 ACQUISITION GROUP, LLC
Reel/Frame 064268/0391 →
Continuity (8)
Division 16728653 · Dec 27, 2019
Continuation 15152192 · May 11, 2016
Division 14975769 · Dec 19, 2015
Provisional Application 62261118 · Nov 30, 2015
Provisional Application 62251082 · Nov 4, 2015
Provisional Application 62220199 · Sep 17, 2015
Provisional Application 62095675 · Dec 22, 2014
Related Publication 20230265189A1 · Aug 24, 2023
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