Cryosurgery coolant delivery system and method of preparing and using the same
A cryosurgery coolant delivery system may include a canister body defining an inner chamber, a canister head portion coupled to the canister, and a coolant contained in the inner chamber. The coolant may include a mixture of 1,1,1,2-tetrafluoroethane (HFC-134a), 2,3,3,3-tetrafluoropropene (HFO-1234yf), pentafluoroethane (HFC-125), and difluoromethane (HFC-32). In other aspects, the coolant may include a mixture of difluoromethane (HFC-32), pentafluoroethane (HFC-125), 1,1,1,2-tetrafluoroethane (HFC-134a), 2,3,3,3-Tetrafluoroprop-1-ene (HFO-1234yf), and trans-1,3,3,3-Tetrafluoroprop-1-ene.
1 . A cryosurgery coolant delivery system, comprising:
a canister body defining an inner chamber;
a canister head portion coupled to the canister body and including a trigger actuator, an outlet, and an outlet channel in fluid communication with the outlet and the inner chamber of the canister body; and
a coolant contained in the inner chamber, the coolant including a mixture of 1,1,1,2-tetrafluoroethane (HFC-134a), 2,3,3,3-tetrafluoropropene (HFO-1234yf), pentafluoroethane (HFC-125), and difluoromethane (HFC-32);
wherein a percent concentration (w/w) of the coolant is about 25.7% 1,1,1,2-tetrafluoroethane (HFC-134a), about 25.3% 2,3,3,3-tetrafluoropropene (HFO-1234yf), about 24.7% pentafluoroethane (HFC-125), and about 24.3% difluoromethane (HFC-32).
2 . The cryosurgery coolant delivery system of claim 1 , further comprising:
a valve stem extending from the outlet channel;
a valve gasket extending from the valve stem;
a spring coupled to the valve gasket; and
a dip tube provided between the outlet and the inner chamber, wherein the outlet, the outlet channel, the valve stem, and the dip tube provide a flow path for the coolant between the inner chamber and the outlet.
3 . The cryosurgery coolant delivery system of claim 1 , further comprising an extender tube configured to detachably couple to the outlet, wherein the extender tube, the outlet, and the outlet channel provide a flow path for the coolant between the interior chamber and the extender tube.
4 . A cryosurgery coolant delivery system, comprising:
a canister body defining an inner chamber;
a canister head portion coupled to the canister body and including a trigger actuator, an outlet, and an outlet channel in fluid communication with the outlet and the inner chamber of the canister body; and
a coolant contained in the inner chamber, the coolant including a mixture of difluoromethane (HFC-32), pentafluoroethane (HFC-125), 1,1,1,2-tetrafluoroethane (HFC-134a), 2,3,3,3-Tetrafluoroprop-1-ene (HFO-1234yf), and trans-1,3,3,3-Tetrafluoroprop-1-ene;
wherein a percent concentration (w/w) of the coolant is about 26.00% difluoromethane, about 26.00% pentafluoroethane, about 21.00% 1,1,1,2-Tetrafluoroethane, about 20.00% 2,3,3,3-tetrafluoroprop-1-ene, and about 7.00% trans-1,3,3,3-Tetrafluoroprop-1-ene.
5 . The cryosurgery coolant delivery system of claim 4 , further comprising:
a valve stem extending from the outlet channel;
a valve gasket extending from the valve stem;
a spring coupled to the valve gasket; and
a dip tube provided between the outlet and the inner chamber, wherein the outlet, the outlet channel, the valve stem, and the dip tube provide a flow path for the coolant between the inner chamber and the outlet.
6 . The cryosurgery coolant delivery system of claim 4 , further comprising an extender tube configured to detachably couple to the outlet, wherein the extender tube, the outlet, and the outlet channel provide a flow path for the coolant between the interior chamber and the extender tube.
7 . A method of administering a coolant for cryosurgical applications, comprising:
identifying a location of a patient's skin surface to be treated;
actuating a trigger of a cryosurgery coolant delivery system, whereby an outlet of a head portion of the cryosurgery coolant delivery system sprays a coolant; and
applying the coolant to the skin surface;
wherein the coolant comprises:
a mixture of 1,1,1,2-tetrafluoroethane (HFC-134a), 2,3,3,3-tetrafluoropropene (HFO-1234yf), pentafluoroethane (HFC-125), and difluoromethane (HFC-32) wherein a percent concentration (w/w) of the coolant is about 25.7% 1,1,1,2-tetrafluoroethane (HFC-134a), about 25.3% 2,3,3,3-tetrafluoropropene (HFO-1234yf), about 24.7% pentafluoroethane (HFC-125), and about 24.3% difluoromethane (HFC-32), or
a mixture of difluoromethane (HFC-32), pentafluoroethane (HFC-125), 1,1,1,2-tetrafluoroethane (HFC-134a), 2,3,3,3-Tetrafluoroprop-1-ene (HFO-1234yf), and trans-1,3,3,3-Tetrafluoroprop-1-ene wherein a percent concentration (w/w) of the coolant is about 26.00% difluoromethane, about 26.00% pentafluoroethane, about 21.00% 1,1,1,2-Tetrafluoroethane, about 20.00% 2,3,3,3-tetrafluoroprop-1-ene, and about 7.00% trans-1,3,3,3-Tetrafluoroprop-1-ene.
8 . The method of claim 7 , further comprising:
contacting the skin surface with an isolation funnel;
dispensing coolant into the isolation funnel so as to accumulate the coolant within the isolation funnel;
wherein the isolation funnel is configured to create a seal against the skin surface so as to prevent migration of the coolant outside of a targeted treatment area.
9 . The method of claim 7 , further comprising:
dispensing the coolant into a foam tip of an applicator so as to saturate the foam tip and freeze the foam tip; and
applying frozen foam tip to the skin surface to provide cryosurgical treatment to the skin surface.
10 . The method of claim 7 , wherein spraying the coolant includes at least one of:
saturating a foam-tipped applicator with the coolant;
saturating foam tips of a pair of tweezers; or
spraying the coolant through a funnel opening of an isolation funnel positioned against the skin surface until an accumulation of the coolant is provided in the isolation funnel.
11 . The method of claim 7 , wherein the coolant is applied to the skin surface until blood supply to the skin surface ceases.
12 . The method of claim 7 , wherein the coolant is applied to the skin surface directly from the outlet.
13 . The cryosurgery coolant delivery system of claim 1 , further comprising an isolation funnel configured to be positioned against a patient's skin,
wherein the system is configured to dispense the coolant into the isolation funnel and accumulate the coolant within the funnel to a targeted treatment area of the patent's skin; and
the isolation funnel is configured to form a seal against the patient's skin so as to prevent migration of the coolant outside of the targeted treatment area.
14 . The cryosurgery coolant delivery system of claim 1 , further comprising an applicator having a foam tip,
wherein the system is configured to apply the coolant to the foam tip to saturate and freeze the foam tip prior to contact with a patient's skin, such that the frozen foam tip provides a cryosurgical interface for contacting the patient's skin.
15 . The cryosurgery coolant delivery system of claim 4 , further comprising an isolation funnel configured to be positioned against a patient's skin,
wherein the system is configured to dispense the coolant into the isolation funnel and accumulate the coolant within the funnel to a targeted treatment area of the patent's skin,
and the isolation funnel is configured to form a seal against the patient's skin so as to prevent migration of the coolant outside of the targeted treatment area.
16 . The cryosurgery coolant delivery system of claim 4 , further comprising an applicator having a foam tip,
wherein the system is configured to apply the coolant to the foam tip to saturate and freeze the foam tip prior to contact with a patient's skin, such that the frozen foam tip provides a cryosurgical interface for contacting the patient's skin.
17 . The method of claim 8 , wherein the coolant is dispensed into the isolation funnel for a period of time in a range of 3 seconds to 6 seconds.
18 . The method of claim 8 , wherein the coolant is accumulated in the isolation funnel to a depth in a range of about ⅛ inches to about ¼ inches.
19 . The method of claim 9 , wherein the coolant is dispensed into the foam tip for at least 10 seconds.
20 . The method of claim 9 , wherein the frozen foam tip is applied to the skin surface for a period of time in a range of 20 seconds to 40 seconds.