IP Library › Granted Patent US 12,730,249
Granted Patent B2
US 12,730,249 · App. 18/871,664 · Granted Sep 8, 2026

Ophthalmic devices containing photostable mimics of macular pigment and other visible light filters

Inventors: Shivkumar Mahadevan (Jacksonville, FL); Dola Sinha (Jacksonville, FL); Derek Nankivil (Jacksonville, FL); Leilani K. Sonoda (Atlantic Beach, FL); Ghulam Maharvi (Jacksonville, FL)
Assignee: Johnson & Johnson Vision Care, Inc.
G02B1/043C08F283/12G02C7/10
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Quick Facts
Patent No.
US 12,730,249
App. No.
18/871,664
Granted
Sep 8, 2026
Kind
B2
Abstract

Described is an ophthalmic device that contains visible light filters. The ophthalmic device is a free radical reaction product of a reactive mixture comprising: one or more monomers suitable for making the ophthalmic device; a first visible light filtering compound, the first visible light filtering compound having a visible light absorption maximum between 430 and 480 nm and a full width half maximum (FWHM) at the visible light absorption maximum of at least 35 nm and up to 150 nanometers, wherein the compound is photostable, and wherein the compound has a molar extinction coefficient of at least 7740 L·mol-1·cm-1; and a second visible light filtering compound. The devices may provide one or more benefits to wearers, including enhanced macular pigment optical density (MPOD), as well as improved color perception and color enhancement.

Claims (98)

1 . An ophthalmic device that is a free radical reaction product of a reactive mixture comprising:

one or more monomers suitable for making the ophthalmic device;

a first visible light filtering compound, the first visible light filtering compound having a visible light absorption maximum between 430 and 480 nm and a full width half maximum (FWHM) at the visible light absorption maximum of at least 35 nm and up to 150 nm, wherein the first visible light filtering compound is photostable, and wherein the first visible light filtering compound has a molar extinction coefficient of at least 7740 L·mol −1 ·cm −1 ; and

a second visible light filtering compound, and

wherein the second visible light filtering compound comprises: a mixture of

(a) a medium energy visible light filter of formula II:

wherein Y at each occurrence is independently a linking group and P g at each occurrence is independently a polymerizable group; and

(b) a high energy visible light filter of formula III:

wherein:

m and n are independently 0, 1, 2, 3, or 4;

T is a bond, O, or NR;

Y is a linking group;

P g is a polymerizable group;

R at each occurrence is independently H, C 1 -C 6 alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or Y—P g ; and

R 1 and R 2 , when present, are independently at each occurrence C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 thioalkyl, C 3 -C 7 cycloalkyl, aryl (preferably unsubstituted phenyl or phenyl substituted with alkyl or halo), halo, hydroxy, amino, NR 3 R 4 , or benzyl, wherein R 3 and R 4 are independently H or C 1 -C 6 alkyl, or two adjacent R 1 or R 2 groups, together with the carbon atoms to which they are attached, combine to form a cycloalkyl or aryl ring; or

(c) a high energy visible light filter of formula IV:

wherein m and n are independently 0, 1, 2, 3, or 4;

R 1 and R 2 are independently at each occurrence H, an optional substituent, or —Y—P g , or two adjacent R 1 or R 2 groups, together with the atoms to which they are attached, combine to form a cycloalkyl or aryl ring optionally substituted with —Y—P g ;

EWG at each occurrence is independently an electron withdrawing group;

P g at each occurrence is independently a polymerizable group; and

Y at each occurrence is independently a linking group; and

wherein the compound of formula IV contains at least one P g group.

2 . The ophthalmic device of claim 1 , wherein the visible light absorption maximum of the first visible light filtering compound is between 440 nm and 470 nm.

3 . The ophthalmic device of claim 1 , wherein the FWHM at the visible light absorption maximum of the first visible light filtering compound is at least 40 nm and up to 95 nm.

4 . The ophthalmic device of claim 1 , wherein photostability comprises a loss of absorbance at the visible light absorption maximum of no more than 20 percent.

5 . The ophthalmic device of claim 1 , wherein photostability comprises being more photostable than macular pigment.

6 . The ophthalmic device of claim 1 , wherein the first visible light filtering compound is thermally stable.

7 . The ophthalmic device of claim 1 , wherein the first visible light filtering compound is more thermally stable than macular pigment.

8 . The ophthalmic device of claim 1 , wherein the reactive mixture further comprises a UV absorbing compound.

9 . The ophthalmic device of claim 1 , wherein the device has a transmittance of:

(a) between 0 percent and 70 percent across a wavelength range of 400 to 409 nm;

(b) between 60 percent and 80 percent across a wavelength range of 430 to 480 nm;

(c) between 50 percent and 95 percent across a wavelength range of 550 nm to 660 nm; and (d) at least 90 percent across a wavelength range of 665 nm to 760 nm.

10 . The ophthalmic device of claim 9 , wherein the device has a transmittance of: (e) at least 90 percent across a wavelength range of 515 nm to 530 nm.

11 . The ophthalmic device of claim 9 , wherein the device has a transmittance of: (f) 35 percent or less across a wavelength range of 280 to 399 nm.

12 . The ophthalmic device of claim 1 , wherein the first visible light filtering compound is of formula I:

wherein m and n are independently 0, 1, 2, 3, or 4; T is a bond, O, or NR 6 , wherein R 6 is H, C 1 -C 6 alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or Y—P g ; R is H, C 1 -C 8 alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; Y is a linking group; P g is a polymerizable group; R 1 and R 2 , when present, are independently at each occurrence C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 thioalkyl, C 3 -C 7 cycloalkyl, aryl, halo, hydroxy, amino, NR 3 R 4 , benzyl, SO 3 H, or SO 3 M, M is a monovalent cation, wherein R 3 and R 4 are independently H or C 1 -C 6 alkyl, or two adjacent R 1 or R 2 groups, together with the carbon atoms to which they are attached, combine to form a cycloalkyl or aryl ring; and EWG is an electron withdrawing group.

13 . The ophthalmic device of claim 12 , wherein m and n are each independently 0 or 1.

14 . The ophthalmic device of claim 12 , wherein Y at each occurrence is independently alkylene, cycloalkylene, heterocycloalkylene, arylene, heteroarylene, oxaalkylene, alkylene-amide-alkylene, alkylene-amine-alkylene, or combinations thereof.

15 . The ophthalmic device of claim 12 , wherein P g comprises styryl, vinyl carbonate, vinyl ether, vinyl carbamate, N-vinyl lactam, N-vinylamide, (meth)acrylate, or (meth)acrylamide.

16 . The ophthalmic device of claim 12 , wherein EWG is cyano, amide, ester, keto, or aldehyde.

17 . The ophthalmic device of claim 12 , wherein EWG is cyano.

18 . The ophthalmic device of claim 1 , wherein the first visible light filtering compound comprises:

2-(2-cyano-2-(2-methoxy-10-propylacridin-9(10H)-ylidene)acetamido)ethyl methacrylate

2-(2-cyano-2-(2-methoxy-10-butylacridin-9(10H)-ylidene)acetamido)ethyl methacrylate;

1-(10-butyl-2-methoxyacridin-9(10H)-ylidene)-1-cyano-2-oxo-6,9,12,15,18-pentaoxa-3-azaicosan-20-yl methacrylate; or

a mixture thereof.

19 . The ophthalmic device of claim 1 , wherein m and n are each independently 0 or 1 in the high energy visible light filter of formula III.

20 . The ophthalmic device of claim 1 , wherein Y at each occurrence is independently alkylene, cycloalkylene, heterocycloalkylene, arylene, heteroarylene, oxaalkylene, alkylene-amide-alkylene, alkylene-amine-alkylene, or combinations thereof, in the high energy visible light filter of formula III.

21 . The ophthalmic device of claim 1 , wherein P g comprises styryl, vinyl carbonate, vinyl ether, vinyl carbamate, N-vinyl lactam, N-vinylamide, (meth)acrylate, or (meth)acrylamide, in the high energy visible light filter of formula III.

22 . The ophthalmic device of claim 1 , wherein the high energy visible light filter of formula III comprises:

2-(2-cyano-2-(9H-thioxanthen-9-ylidene)acetamido)ethyl methacrylate;

2-(2-cyano-2-(9H-thioxanthen-9-ylidene)acetamido)ethyl acrylate;

N-(2-(2-cyano-2-(9H-thioxanthen-9-ylidene)acetamido)ethyl)methacrylamide;

N-(2-(2-cyano-2-(9H-thioxanthen-9-ylidene)acetamido)ethyl)acrylamide;

2-(2-cyano-N-methyl-2-(9H-thioxanthen-9-ylidene)acetamido)ethyl methacrylate;

2-cyano-2-(9H-thioxanthen-9-ylidene)-N-(2-(N-vinylacetamido)ethyl)acetamide;

2-(2-cyano-2-(9H-thioxanthen-9-ylidene)acetamido)-2-methylpropyl methacrylate;

2-(2-cyano-2-(2,4-dichloro-9H-thioxanthen-9-ylidene)acetamido)ethyl methacrylate;

2-(2-(2-chloro-9H-thioxanthen-9-ylidene)-2-cyanoacetamido)ethyl methacrylate;

2-(2-cyano-2-(2-isopropyl-9H-thioxanthen-9-ylidene)acetamido)ethyl methacrylate;

2-(2-cyano-2-(4-isopropyl-9H-thioxanthen-9-ylidene)acetamido)ethyl methacrylate;

2-(2-cyano-2-(9H-thioxanthen-9-ylidene)acetoxy)ethyl methacrylate;

1-cyano-2-oxo-1-(9H-thioxanthen-9-ylidene)-6,9,12,15,18-pentaoxa-3-azaicosan-20-yl methacrylate; or

mixtures of two or more thereof.

23 . The ophthalmic device of claim 1 , wherein m and n are independently 0 or 1 in the high energy visible light filter of formula IV.

24 . The ophthalmic device of claim 1 , wherein R 1 is H, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 thioalkyl, C 3 -C 7 cycloalkyl, aryl, halo, hydroxy, amino, NR 4 R 5 , benzyl, SO 3 H, or SO 3 Na, wherein R 4 and R 5 are independently H or C 1 -C 6 alkyl in the high energy visible light filter of formula IV.

25 . The ophthalmic device of claim 1 , wherein R 2 is —Y—P g in the high energy visible light filter of formula IV.

26 . The ophthalmic device of claim 1 , wherein P g at each occurrence independently comprises styryl, vinyl carbonate, vinyl ether, vinyl carbamate, N-vinyl lactam, N-vinylamide, (meth)acrylate, or (meth)acrylamide in the high energy visible light filter of formula IV.

27 . The ophthalmic device of claim 1 , wherein Y at each occurrence is independently alkylene, cycloalkylene, heterocycloalkylene, arylene, heteroarylene, oxaalkylene, alkylene-amide-alkylene, alkylene-amine-alkylene, or combinations of any of the foregoing groups in the high energy visible light filter of formula IV.

28 . The ophthalmic device of claim 1 , wherein EWG at each occurrence is independently cyano, amide, ester, keto, or aldehyde in the high energy visible light filter of formula IV.

29 . The ophthalmic device of claim 1 , wherein the second high energy visible light filter compound of formula III contains one Y-P g group.

30 . The ophthalmic device of claim 1 , wherein the compound of formula IV comprises:

3-((9-(dicyanomethylene)-9H-xanthen-3-yl)oxy)propyl methacrylate;

3-((9-(dicyanomethylene)-9H-xanthen-2-yl)oxy)propyl methacrylate;

1-((9-(dicyanomethylene)-9H-xanthen-3-yl)oxy)propan-2-yl methacrylate;

4-((9-(dicyanomethylene)-9H-xanthen-3-yl)oxy)butyl methacrylate;

3-((9-(dicyanomethylene)-9H-xanthen-3-yl)oxy)propyl acrylate;

1-((9-(dicyanomethylene)-9H-xanthen-3-yl)oxy)propan-2-yl acrylate;

4-((9-(dicyanomethylene)-9H-xanthen-3-yl)oxy)butyl acrylate;

N-(3-((9-(dicyanomethylene)-9H-xanthen-3-yl)oxy)propyl)methacrylamide;

N-(3-((9-(dicyanomethylene)-9H-xanthen-3-yl)oxy)propyl)acrylamide;

3-((9-(dicyanomethylene)-9H-xanthen-3-yl)amino)propyl methacrylate;

17-((9-(dicyanomethylene)-9H-xanthen-3-yl)oxy)-3,6,9,12,15-pentaoxaheptadecyl methacrylate;

or mixtures of two or more thereof.

31 . The ophthalmic device of claim 1 , that wherein the device is formed by photocuring of the reactive mixture.

32 . The ophthalmic device of claim 1 , wherein the device is formed by thermal curing of the reactive mixture.

33 . The ophthalmic device of claim 1 , wherein the device is formed by a combination of photocuring and thermal curing of the reactive mixture.

34 . The ophthalmic device of claim 1 , wherein the device is a contact lens, the contact lens having a central zone and a peripheral zone.

35 . The ophthalmic device of claim 34 , wherein the first visible light filtering compound's residue and the second visible light filtering compound's residue are uniformly distributed throughout the central zone and the peripheral zone.

36 . The ophthalmic device of claim 34 , wherein the first visible light filtering compound's residue and the second visible light filtering compound's residue are present in the central zone at a greater molar concentration than in the peripheral zone.

37 . The ophthalmic device of claim 1 , wherein the reactive mixture further comprises a UV absorbing compound, wherein the UV absorbing compound comprises a benzophenone, a benzotriazole, a triazine, a substituted acrylonitrile, a salicyclic acid derivative, a benzoic acid derivative, a cinnamic acid derivative, a chalcone derivative, a dypnone derivative, a crotonic acid derivative, or mixtures thereof.

38 . The ophthalmic device of claim 1 , wherein the polymerizable compound suitable for making the contact lens comprises a hydrophilic component, a silicone-containing component, or mixtures thereof.

39 . The ophthalmic device of claim 1 , wherein the device is a silicone hydrogel contact lens, the lens having a contact angle of about 100° or less, a water content of at least about 25 weight percent, and an oxygen permeability (edge corrected) of at least about 60 barrers.

40 . The ophthalmic device of claim 1 , wherein the second visible light filtering compound:

(a) limits the transmittance of the device across a wavelength range of 550 nm to 660 nm to between 50 percent and 95 percent; or

(b) limits the transmittance of the device across a wavelength range of 400 to 409 nm to between 0 percent and 70 percent; or

(c) both (a) and (b).

Continuity (2)
Provisional Application 63366471 · Jun 16, 2022
Related Publication 20250362432A1 · Nov 27, 2025
References Cited (385)
US 3196150A · Martin · 1965 [cited by applicant]
US 3376303A · Otto et al. · 1968 [cited by applicant]
US 3408429A · Wichterle · 1968 [cited by applicant]
US 3660545A · Wichterle · 1972 [cited by applicant]
US 3769294A · Catino et al. · 1973 [cited by applicant]
US 3808178A · Gaylord · 1974 [cited by applicant]
US 4113224A · Clark et al. · 1978 [cited by applicant]
US 4120570A · Gaylord · 1978 [cited by applicant]
US 4136250A · Mueller et al. · 1979 [cited by applicant]
US 4153641A · Deichert et al. · 1979 [cited by applicant]
US 4197266A · Clark et al. · 1980 [cited by applicant]
US 4436887A · Chromecek et al. · 1984 [cited by applicant]
US 4495313A · Larsen · 1985 [cited by applicant]
US 4659763A · Gallucci et al. · 1987 [cited by applicant]
US 4659782A · Spinelli · 1987 [cited by applicant]
US 4659783A · Spinelli · 1987 [cited by applicant]
US 4716234A · Dunks et al. · 1987 [cited by applicant]
US 4740533A · Su et al. · 1988 [cited by applicant]
US 4889664A · Kindt-Larsen et al. · 1989 [cited by applicant]
US 4910277A · Bambury et al. · 1990 [cited by applicant]
US 4997897A · Melpolder · 1991 [cited by applicant]
US 5006622A · Kunzler et al. · 1991 [cited by applicant]
US 5034461A · Lai et al. · 1991 [cited by applicant]
US 5039459A · Kindt-Larsen et al. · 1991 [cited by applicant]
US 5070215A · Bambury et al. · 1991 [cited by applicant]
US 5236969A · Kunzler et al. · 1993 [cited by applicant]
US 5244981A · Seidner et al. · 1993 [cited by applicant]
US 5270418A · Kunzler et al. · 1993 [cited by applicant]
US 5298533A · Nandu et al. · 1994 [cited by applicant]
US 5314960A · Spinelli et al. · 1994 [cited by applicant]
US 5331067A · Seidner et al. · 1994 [cited by applicant]
US 5371147A · Spinelli et al. · 1994 [cited by applicant]
US 5470932A · Jinkerson · 1995 [cited by applicant]
US 5480927A · Janssen et al. · 1996 [cited by applicant]
US 5729322A · Collins et al. · 1998 [cited by applicant]
US 5789461A · Nicolson et al. · 1998 [cited by applicant]
US 5824719A · Kunzler et al. · 1998 [cited by applicant]
US 5849811A · Nicolson et al. · 1998 [cited by applicant]
US 5872118A · Kelley et al. · 1999 [cited by applicant]
US 5916719A · Kim et al. · 1999 [cited by applicant]
US 5944853A · Molock et al. · 1999 [cited by applicant]
US 5945465A · Ozark et al. · 1999 [cited by applicant]
US 5962548A · Vanderlaan et al. · 1999 [cited by applicant]
US 5965631A · Nicolson et al. · 1999 [cited by applicant]
US 5977219A · Ravichandran et al. · 1999 [cited by applicant]
US 5998498A · Vanderlaan et al. · 1999 [cited by applicant]
US 6020445A · Vanderlaan et al. · 2000 [cited by applicant]
US 6022158A · Nakayama et al. · 2000 [cited by applicant]
US 6087415A · Vanderlaan et al. · 2000 [cited by applicant]
US 6096246A · Chan et al. · 2000 [cited by applicant]
US 5760100B1 · Nicolson et al. · 2000 [cited by applicant]
US 5776999B1 · Nicolson et al. · 2000 [cited by applicant]
US 6158862A · Patel et al. · 2000 [cited by applicant]
US 6166218A · Ravichandran et al. · 2000 [cited by applicant]
US 6207244B1 · Hesch · 2001 [cited by applicant]
US 6244707B1 · Faubl · 2001 [cited by applicant]
US 6367929B1 · Maiden et al. · 2002 [cited by applicant]
US 6373615B1 · Mann et al. · 2002 [cited by applicant]
US 6420453B1 · Bowers et al. · 2002 [cited by applicant]
US 6423761B1 · Bowers et al. · 2002 [cited by applicant]
US 6527977B2 · Helber et al. · 2003 [cited by applicant]
US 6767979B1 · Muir et al. · 2004 [cited by applicant]
US 6807745B2 · Orton · 2004 [cited by applicant]
US 6822016B2 · Mccabe et al. · 2004 [cited by applicant]
US 6867245B2 · Iwata et al. · 2005 [cited by applicant]
US 6918931B2 · Lai et al. · 2005 [cited by applicant]
US 6943203B2 · Vanderlaan et al. · 2005 [cited by applicant]
US 6951894B1 · Nicolson et al. · 2005 [cited by applicant]
US 7033391B2 · Lai et al. · 2006 [cited by applicant]
US 7052131B2 · McCabe et al. · 2006 [cited by applicant]
US 7247692B2 · Laredo · 2007 [cited by applicant]
US 7249848B2 · Laredo et al. · 2007 [cited by applicant]
US 7276544B2 · Lai et al. · 2007 [cited by applicant]
US 7396890B2 · Zanini et al. · 2008 [cited by applicant]
US 7461937B2 · Steffen et al. · 2008 [cited by applicant]
US 7468398B2 · Nicolson et al. · 2008 [cited by applicant]
US 7538146B2 · Nicolson et al. · 2009 [cited by applicant]
US 7553860B2 · Old · 2009 [cited by applicant]
US 7553880B2 · Nicolson et al. · 2009 [cited by applicant]
US 7572841B2 · Chen et al. · 2009 [cited by applicant]
US 7666921B2 · Mccabe et al. · 2010 [cited by applicant]
US 7691916B2 · McCabe et al. · 2010 [cited by applicant]
US 7691918B2 · Jinkerson et al. · 2010 [cited by applicant]
US 7728051B2 · Weinschenk et al. · 2010 [cited by applicant]
US 7781571B2 · Weinschenk et al. · 2010 [cited by applicant]
US 7786185B2 · Rathore et al. · 2010 [cited by applicant]
US 7803359B1 · Jinkerson et al. · 2010 [cited by applicant]
US 7825170B2 · Steffen et al. · 2010 [cited by applicant]
US 7915323B2 · Awasthi et al. · 2011 [cited by applicant]
US 7934830B2 · Blackwell et al. · 2011 [cited by applicant]
US 7956131B2 · Arnold et al. · 2011 [cited by applicant]
US 7994356B2 · Awasthi et al. · 2011 [cited by applicant]
US 8022158B2 · Rathore et al. · 2011 [cited by applicant]
US 8026326B2 · Benz et al. · 2011 [cited by applicant]
US 8043607B2 · Jinkerson · 2011 [cited by applicant]
US 8113655B1 · Tyrin et al. · 2012 [cited by applicant]
US 8138290B2 · Blackwell et al. · 2012 [cited by applicant]
US 8153703B2 · Laredo · 2012 [cited by applicant]
US 8163206B2 · Chang et al. · 2012 [cited by applicant]
US 8207244B2 · Laredo · 2012 [cited by applicant]
US 8236053B1 · Freeman · 2012 [cited by applicant]
US 8262947B2 · Laredo · 2012 [cited by applicant]
US 8262948B2 · Laredo et al. · 2012 [cited by applicant]
US 8273802B2 · Laredo et al. · 2012 [cited by applicant]
US 8323631B2 · Jinkerson · 2012 [cited by applicant]
US 8329775B2 · Laredo · 2012 [cited by applicant]
US 8360574B2 · Ishak et al. · 2013 [cited by applicant]
US 8389597B2 · Blackwell et al. · 2013 [cited by applicant]
US 8399538B2 · Steffen et al. · 2013 [cited by applicant]
US 8415404B2 · Nicolson et al. · 2013 [cited by applicant]
US 8420711B2 · Awasthi et al. · 2013 [cited by applicant]
US 8431624B2 · Domschke et al. · 2013 [cited by applicant]
US 8450387B2 · Mccabe et al. · 2013 [cited by applicant]
US 8470906B2 · Rathore et al. · 2013 [cited by applicant]
US 8476390B2 · Benz et al. · 2013 [cited by applicant]
US 8487058B2 · Liu et al. · 2013 [cited by applicant]
US 8507577B2 · Zanini et al. · 2013 [cited by applicant]
US 8568626B2 · Nicolson et al. · 2013 [cited by applicant]
US 8585938B1 · Jinkerson et al. · 2013 [cited by applicant]
US 8618323B2 · Benz et al. · 2013 [cited by applicant]
US 8637621B2 · Iwata et al. · 2014 [cited by applicant]
US 8697770B2 · Duis et al. · 2014 [cited by applicant]
US 8703891B2 · Broad · 2014 [cited by applicant]
US 8784867B2 · Samuel et al. · 2014 [cited by applicant]
US 8807745B2 · Nunez et al. · 2014 [cited by applicant]
US 8937110B2 · Alli et al. · 2015 [cited by applicant]
US 8937111B2 · Alli et al. · 2015 [cited by applicant]
US 8940812B2 · Reboul et al. · 2015 [cited by applicant]
US 8980972B2 · Driver · 2015 [cited by applicant]
US 9005700B2 · Bothe et al. · 2015 [cited by applicant]
US 9056878B2 · Fujisawa et al. · 2015 [cited by applicant]
US 9057821B2 · Broad et al. · 2015 [cited by applicant]
US 9125808B2 · Alli et al. · 2015 [cited by applicant]
US 9125829B2 · Bonda et al. · 2015 [cited by applicant]
US 9140825B2 · Alli et al. · 2015 [cited by applicant]
US 9145383B2 · Bonda et al. · 2015 [cited by applicant]
US 9156934B2 · Alli et al. · 2015 [cited by applicant]
US 9170349B2 · Mahadevan et al. · 2015 [cited by applicant]
US 9217813B2 · Liu et al. · 2015 [cited by applicant]
US 9244196B2 · Scales et al. · 2016 [cited by applicant]
US 9244197B2 · Alli et al. · 2016 [cited by applicant]
US 9249249B2 · Awasthi et al. · 2016 [cited by applicant]
US 9260544B2 · Rathore et al. · 2016 [cited by applicant]
US 9278949B2 · Loccufier · 2016 [cited by applicant]
US 9297928B2 · Molock et al. · 2016 [cited by applicant]
US 9297929B2 · Scales et al. · 2016 [cited by applicant]
US 9315669B2 · Holland et al. · 2016 [cited by applicant]
US 9439487B2 · Barre et al. · 2016 [cited by applicant]
US 9611246B2 · Bonda et al. · 2017 [cited by applicant]
US 9637444B2 · Qian · 2017 [cited by applicant]
US 9667800B2 · Rodriguez et al. · 2017 [cited by applicant]
US 9733493B2 · Wooley · 2017 [cited by applicant]
US 9765051B2 · Bonda et al. · 2017 [cited by applicant]
US 9816009B2 · Qiu et al. · 2017 [cited by applicant]
US 9867800B2 · Bonda et al. · 2018 [cited by applicant]
US 9926289B2 · Bonda et al. · 2018 [cited by applicant]
US 9927635B2 · Ishak et al. · 2018 [cited by applicant]
US 9957258B2 · Kunimoto et al. · 2018 [cited by applicant]
US 10113075B2 · Nesvadba et al. · 2018 [cited by applicant]
US 10254443B2 · Mccabe et al. · 2019 [cited by applicant]
US 10268053B2 · Holland et al. · 2019 [cited by applicant]
US 10338408B2 · Bothe et al. · 2019 [cited by applicant]
US 10597515B2 · Nesvadba et al. · 2020 [cited by applicant]
US 10845625B2 · Carrega et al. · 2020 [cited by applicant]
US 10935695B2 · Mahadevan et al. · 2021 [cited by applicant]
US 11401400B2 · Shishino et al. · 2022 [cited by applicant]
US 11543683B2 · Mahadevan et al. · 2023 [cited by applicant]
US 11820899B2 · Mahadevan et al. · 2023 [cited by applicant]
US 11993034B2 · Brickey et al. · 2024 [cited by applicant]
US 11993037B1 · Mahadevan et al. · 2024 [cited by applicant]
US 20020042653A1 · Copeland et al. · 2002 [cited by applicant]
US 20040070726A1 · Ishak · 2004 [cited by applicant]
US 20050018131A1 · Ishak · 2005 [cited by applicant]
US 20050055090A1 · Lai et al. · 2005 [cited by applicant]
US 20050055091A1 · Lai et al. · 2005 [cited by applicant]
US 20050243272A1 · Mainster et al. · 2005 [cited by applicant]
US 20050254003A1 · Jani et al. · 2005 [cited by applicant]
US 20060092374A1 · Ishak · 2006 [cited by applicant]
US 20060252850A1 · Jani et al. · 2006 [cited by applicant]
US 20070032717A1 · Brister et al. · 2007 [cited by applicant]
US 20070092830A1 · Lai et al. · 2007 [cited by applicant]
US 20070092831A1 · Lai et al. · 2007 [cited by applicant]
US 20070100018A1 · Hagting et al. · 2007 [cited by applicant]
US 20070216861A1 · Ishak et al. · 2007 [cited by applicant]
US 20080002147A1 · Haywood et al. · 2008 [cited by applicant]
US 20080221674A1 · Blum et al. · 2008 [cited by applicant]
US 20100048847A1 · Broad · 2010 [cited by applicant]
US 20100113641A1 · Laredo · 2010 [cited by applicant]
US 20100168359A1 · Domschke et al. · 2010 [cited by applicant]
US 20100321632A1 · Sanger · 2010 [cited by applicant]
US 20110245818A1 · Weinschenk, III · 2011 [cited by applicant]
US 20110249234A1 · Duis et al. · 2011 [cited by applicant]
US 20120010703A1 · Paul et al. · 2012 [cited by applicant]
US 20120053313A1 · Higgs et al. · 2012 [cited by applicant]
US 20120196951A1 · Mentak · 2012 [cited by applicant]
US 20120262792A1 · Goldberg et al. · 2012 [cited by applicant]
US 20120309899A1 · Akinay et al. · 2012 [cited by applicant]
US 20130009059A1 · Shelton et al. · 2013 [cited by applicant]
US 20130057824A1 · Harding et al. · 2013 [cited by applicant]
US 20130095235A1 · Bothe et al. · 2013 [cited by applicant]
US 20130158150A1 · Zhang et al. · 2013 [cited by applicant]
US 20130168617A1 · Alli et al. · 2013 [cited by applicant]
US 20130172440A1 · Alli et al. · 2013 [cited by applicant]
US 20130217620A1 · Alli et al. · 2013 [cited by applicant]
US 20140024791A1 · Alli et al. · 2014 [cited by applicant]
US 20140031447A1 · Alli et al. · 2014 [cited by applicant]
US 20140044654A1 · Bonda et al. · 2014 [cited by applicant]
US 20140050681A1 · Bonda et al. · 2014 [cited by applicant]
US 20140093661A1 · Trajkovska et al. · 2014 [cited by applicant]
US 20140178595A1 · Bothe et al. · 2014 [cited by applicant]
US 20140300857A1 · Cohen-tannoudji et al. · 2014 [cited by applicant]
US 20150092155A1 · Chang et al. · 2015 [cited by applicant]
US 20150094393A1 · Holland et al. · 2015 [cited by applicant]
US 20150094395A1 · Alli et al. · 2015 [cited by applicant]
US 20150164852A1 · Bonda et al. · 2015 [cited by applicant]
US 20150175732A1 · Awasthi et al. · 2015 [cited by applicant]
US 20150316688A1 · Cefalo et al. · 2015 [cited by applicant]
US 20160002200A1 · Bonda et al. · 2016 [cited by applicant]
US 20160022555A1 · Bonda et al. · 2016 [cited by applicant]
US 20160024046A1 · Bonda et al. · 2016 [cited by applicant]
US 20160170093A1 · Laredo et al. · 2016 [cited by applicant]
US 20170038605A1 · Legerton · 2017 [cited by applicant]
US 20170075137A1 · Lin et al. · 2017 [cited by applicant]
US 20170131574A1 · Lee · 2017 [cited by applicant]
US 20170184878A1 · Duis et al. · 2017 [cited by applicant]
US 20170227790A1 · Lin et al. · 2017 [cited by applicant]
US 20170261768A1 · Ambler et al. · 2017 [cited by applicant]
US 20180037690A1 · Aitken et al. · 2018 [cited by applicant]
US 20180164608A1 · Schmeder et al. · 2018 [cited by applicant]
US 20180208583A1 · Kunimoto et al. · 2018 [cited by applicant]
US 20180263951A1 · Bonda et al. · 2018 [cited by applicant]
US 20180371139A1 · Mahadevan et al. · 2018 [cited by applicant]
US 20190002415A1 · Mahadevan et al. · 2019 [cited by applicant]
US 20190002459A1 · Mahadevan et al. · 2019 [cited by applicant]
US 20190121162A1 · Alli et al. · 2019 [cited by applicant]
US 20190169438A1 · Fromentin et al. · 2019 [cited by applicant]
US 20190179170A1 · Chang et al. · 2019 [cited by applicant]
US 20190271798A1 · Mahadevan · 2019 [cited by examiner]
US 20190271861A1 · Hose · 2019 [cited by applicant]
US 20200347166A1 · Alli et al. · 2020 [cited by applicant]
US 20200347167A1 · Alli et al. · 2020 [cited by applicant]
US 20200399429A1 · Alli et al. · 2020 [cited by applicant]
US 20200407324A1 · Mahadevan et al. · 2020 [cited by applicant]
US 20200407337A1 · Mahadevan · 2020 [cited by examiner]
US 20210061934A1 · Martin et al. · 2021 [cited by applicant]
US 20210063770A1 · Mahadevan et al. · 2021 [cited by applicant]
US 20210109255A1 · Mahadevan et al. · 2021 [cited by applicant]
US 20220194944A1 · Mahadevan · 2022 [cited by applicant]
US 20220340759A1 · Riederer et al. · 2022 [cited by applicant]
US 20220340760A1 · Nankivil et al. · 2022 [cited by applicant]
US 20230066936A1 · Buch et al. · 2023 [cited by applicant]
US 20230085695A1 · Buch et al. · 2023 [cited by applicant]
US 20230117655A1 · Mahadevan et al. · 2023 [cited by applicant]
US 20230288728A1 · Mahadevan et al. · 2023 [cited by applicant]
US 20230296807A1 · Aitken et al. · 2023 [cited by applicant]
US 20260003209A1 · Martin et al. · 2026 [cited by applicant]
CN 203965745U · 2014 [cited by applicant]
CN 106349212A · 2017 [cited by applicant]
CN 106366241A · 2017 [cited by applicant]
CN 108586289A · 2018 [cited by applicant]
EP 0080539B1 · 1986 [cited by applicant]
EP 0131468B1 · 1990 [cited by applicant]
EP 0924203A1 · 1999 [cited by applicant]
EP 1870735A1 · 2007 [cited by applicant]
EP 2123638A1 · 2009 [cited by applicant]
EP 3052534A1 · 2016 [cited by applicant]
EP 3419961A1 · 2019 [cited by applicant]
EP 3052534B1 · 2019 [cited by applicant]
EP 3419961B1 · 2020 [cited by applicant]
GB 217810A · 1924 [cited by applicant]
GB 2319035A · 1998 [cited by applicant]
JP H0743918A · 1995 [cited by applicant]
JP 2004243596A · 2004 [cited by applicant]
JP 2004277581A · 2004 [cited by applicant]
JP 2008050463A · 2008 [cited by applicant]
JP 4627009B2 · 2011 [cited by applicant]
JP 2011219512A · 2011 [cited by applicant]
JP 2015118122A · 2015 [cited by applicant]
JP 2016133593A · 2016 [cited by applicant]
RU 2196557C2 · 2003 [cited by applicant]
RU 2197907C2 · 2003 [cited by applicant]
RU 2294132C2 · 2007 [cited by applicant]
RU 2466173C1 · 2012 [cited by applicant]
WO 9963366A1 · 1999 [cited by applicant]
WO 0130866A1 · 2001 [cited by applicant]
WO 0212205A1 · 2002 [cited by applicant]
WO 0242281A1 · 2002 [cited by applicant]
WO 03022321A2 · 2003 [cited by applicant]
WO 03089519A1 · 2003 [cited by applicant]
WO 2007050395A2 · 2007 [cited by applicant]
WO 2008061992A2 · 2008 [cited by applicant]
WO 2008078804A1 · 2008 [cited by applicant]
WO 2011130139A1 · 2011 [cited by applicant]
WO 2013055746A1 · 2013 [cited by applicant]
WO 2013188825A1 · 2013 [cited by applicant]
WO 2014018208A1 · 2014 [cited by applicant]
WO 2014025370A1 · 2014 [cited by applicant]
WO 2014026151A1 · 2014 [cited by applicant]
WO 2015048035 · 2015 [cited by applicant]
WO 2015155748A1 · 2015 [cited by applicant]
WO 2016100457A1 · 2016 [cited by applicant]
WO 2016175619A1 · 2016 [cited by applicant]
WO 2017073467A1 · 2017 [cited by applicant]
WO 2017106322A1 · 2017 [cited by applicant]
WO 2019156143A1 · 2019 [cited by applicant]
WO 2019166971A1 · 2019 [cited by applicant]
WO 2020177534A1 · 2020 [cited by applicant]
WO 2020261091A1 · 2020 [cited by applicant]
Maas et al., “Dication Ethers—10. Stable Dipoles from a Bis-Acridinium Ether Salt and Cyclic Beta-Diketonates”, Tetrahedron, vol. 41, No. 20, pp. 4529-4536, 1985. [cited by applicant]
Ma et al., “Studies on K2CO3-Catalyzed 1,4-Addition of 1,2-Allenic Ketones with Diethyl Malonate: Controlled Selective Synthesis of β,γ-Unsaturated Enones and α-Pyrones”, Journal of Organic Chemistry, vol. 68, pp. 8996-… [cited by applicant]
Krick et al. “Temperature-Dependent Dynamics of Push-Pull Rotor Systems Based on Acridinylidene Cyanoacetic Esters”, European Journal of Organic Chemistry, pp. 5141-5146, Jul. 26, 2017. [cited by applicant]
“Guidance for Industry: Q1B Photostability Testing of New Drug Substances and Products”, International Conference on Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use guidel… [cited by applicant]
“Statement on Ocular Ultraviolet Radiation Hazards in Sunlight”, American Optometric Association, pp. 1-3, Nov. 10, 1993. [cited by applicant]
Beatty et al., “Macular Pigment and Age Related Macular Degeneration”, British Journal of Ophthalmology, vol. 83, pp. 867-877, 1999. [cited by applicant]
Belikov, V.G., “The Relationship Between Chemical Structure, Properties of Substances and Their Effect on the Organism”, Pharmaceutical Chemistry, pp. 27-29, 2007. [cited by applicant]
Belusa et al., “2-(2-hydroxyphenyl)benzotriazoles. I. Synthesis and Their Ultraviolet and Infrared Spectra”, Department of Organic Chemistry, Chem.Zvesti, vol. 28, No. 5, pp. 673-679, Jan. 14, 1974. [cited by applicant]
Berg, Van Den, “Importance of Pathological Intraocular Light Scatter for Visual Disability”, Documenta Ophthalmologica, vol. 61, pp. 327-333, 1986. [cited by applicant]
Bernstein et al., “Lutein, Zeaxanthin, and Meso-zeaxanthin: the Basic and Clinical Science Underlying Carotenoid- based Nutritional Interventions Against Ocular Disease”, Progress in Retinal and Eye Research, vol. 50, p… [cited by applicant]
Berthon et al., “Synthesis, Electrochemical and Spectroscopic Properties of Pendant Hydroquinone-and Quinone- substitued Polypyridyl Ruthenium(li) Complexes”, Inorganica Himica Acta, vol. 204, pp. 3-7, 1993. [cited by applicant]
Bondyreva, E.U., “Polymerization- Methodological Guidelines for Independent Work”, Kazan National Research Technological University, Nizhnekamsk, pp. 4-13, 2014. [cited by applicant]
Boon et al., “Factors Influencing the Chemical Stability of Carotenoids in Foods”, Critical Reviews in Food Science and Nutrition, vol. 50, pp. 515-532, 2010. [cited by applicant]
Burton et al., “B-carotene Autoxidation: Oxygen Copolymerization, Non-vitamin A Products, and Immunological Activity”, Canadian Journal of Chemistry, vol. 92, pp. 305-316, 2014. [cited by applicant]
Chakrabarti et al., “Statistics of Real-World Hyperspectral Images”, CVPR, pp. 193-200, Jun. 20-25, 2011. [cited by applicant]
Chen et al., “Dicyanomethylenated Acridone Based Crystals: Torsional Vibration Confinement Induced Emission with Supramolecular Structure Dependent and Stimuli Responsive Characteristics”, The Journal of Physical Chemis… [cited by applicant]
Crivello et al., “Photoinitiators for Free Radical Cationic and Anionic Photopolymerisation”, Chemistry and Technology of UV and EB Formulation for Coatings, Inks & Paints, 2nd Edition, 26 pages, 1998. [cited by applicant]
Das et al., “In Vitro and Schematic Model Eye Assessment of Glare or Positive Dysphotopsia-type Photic Phenomena: Comparison of a New Material lol to Other Monofocal lols”, Journal of Cataract and Refractive Surgery, vo… [cited by applicant]
Doutch et al., “Ultraviolet Light Transmission Through the Human Corneal Stroma is Reduced in the Periphery”, Biophysical Journal, vol. 102, No. 6, pp. 1258-1264, 2012. [cited by applicant]
Dyson et al., “Chemistry of Synthetic Drugs Substances”, Moscow: Mir, 9 pages, 1964. [cited by applicant]
Elsherif et al., “Contact Lenses for Color Vision Deficiency”, Advanced Materials Technologies, vol. 6, No. 1, pp. 1-9, Jan. 2021. [cited by applicant]
Fadli et al., “Permeation and Pervaporation of Water Through Contact Lens Materials”, 3 pages, 2016. [cited by applicant]
Foster et al., “Frequency of Metamerism in Natural Scenes”, Journal of the Optical Society of America, vol. 23, No. 10, pp. 2359-2372, Oct. 2006. [cited by applicant]
Hafez et al., “Carbonyl and Thiocarbonyl Compounds. V. Synthesis of Newer Unsaturated Nitriles, Carboxylic Acids, and Esters Derived From Xanthene and Thiaxanthene”, Journal of Organic Chemistry, vol. 26, pp. 3988-3991,… [cited by applicant]
Ham et al., “Retinal Sensitivity to Damage from Short Wavelength Light”, Nature, vol. 260, No. 5547, pp. 153-155, Mar. 11, 1976. [cited by applicant]
Hammond et al., “Contralateral Comparison of Blue-filtering and Non-blue-filtering Intraocular Lenses: Glare Disability, Heterochromatic Contrast, and Photostress Recovery”, Clinical Ophthalmology, vol. 4, pp. 1465-1473… [cited by applicant]
Harris et al., “Effect of Tinted Contact Lenses on Color Vision”, Journal of Optometry & Physiological Optics, vol. 53, No. 3, pp. 145-148, Mar. 1976. [cited by applicant]
International Preliminary Report on Patentability, received for PCT Application No. PCT/IB2019/051582, mailed on Sep. 8, 2020, 10 pages. [cited by applicant]
International Preliminary Report on Patentability, received for PCT Application No. PCT/IB2020/055485, mailed on Dec. 28, 2021, 08 pages. [cited by applicant]
International Preliminary Report on Patentability, received for PCT Application No. PCT/IB2020/055868, mailed on Dec. 28, 2021, 09 pages. [cited by applicant]
International Preliminary Report on Patentability, received for PCT Application No. PCT/IB2020/057732, mailed on Mar. 1, 2022, 8 pages. [cited by applicant]
International Preliminary Report on Patentability, received for PCT Application No. PCT/IB2020/057733, mailed on Mar. 1, 2002, 9 pages. [cited by applicant]
International Preliminary Report on Patentability, received for PCT Application No. PCT/IB2021/061175, mailed on Jun. 13, 2023, 7 pages. [cited by applicant]
International Search Report and Written Opinion, received for PCT Application No. PCT/IB2018/053669, mailed on Jul. 17, 2018, 14 pages. [cited by applicant]
International Search Report and Written Opinion, received for PCT Application No. PCT/IB2018/054585, mailed on Nov. 9, 2018, 12 pages. [cited by applicant]
International Search Report and Written Opinion, received for PCT Application No. PCT/IB2018/054588, mailed on Oct. 4, 2018, 17 pages. [cited by applicant]
International Search Report and Written Opinion, received for PCT Application No. PCT/IB2019/051582, mailed on May 24, 2019, 18 pages. [cited by applicant]
International Search Report and Written Opinion, received for PCT Application No. PCT/IB2020/055485, mailed on Jul. 23, 2020, 16 pages. [cited by applicant]
International Search Report and Written Opinion, received for PCT Application No. PCT/IB2020/055868, mailed on Sep. 23, 2020, 16 pages. [cited by applicant]
International Search Report and Written Opinion, received for PCT Application No. PCT/IB2020/057732, mailed on Oct. 9, 2020, 15 pages. [cited by applicant]
International Search Report and Written Opinion, received for PCT Application No. PCT/IB2020/057733, mailed on Oct. 9, 2020, 16 pages. [cited by applicant]
International Search Report and Written Opinion, received for PCT Application No. PCT/IB2021/061175, mailed on Mar. 1, 2022, 15 pages. [cited by applicant]
International Search Report and Written Opinion, received for PCT Application No. PCT/IB2023/055938, mailed on Oct. 18, 2023, 12 pages. [cited by applicant]
ISO 18369-3, “Ophthalmic Optics-Contact lenses—Part 3: Measurement Methods”, International Organization for Standardization, Aug. 15, 2006, 44 pages. [cited by applicant]
ISO 18369-4, “Ophthalmic Optics-Contact Lenses—Part 4: Physicochemical Properties of Contact Lens Materials”, International Organization for Standardization, Aug. 15, 2006, 38 pages. [cited by applicant]
ISO 9913-1, “Optics and Optical Instruments—Contact Lenses—Part 1: Determination of Oxygen Permeability and Transmissibility by the FATT Method”, International Organization for Standardization, Nov. 1, 1996, 16 pages. [cited by applicant]
Jockusch et al., “Photostabilization of Endogenous Porphyrins: Excited State Quenching by Fused Ring Cyanoacrylates”, Photchemical and Photobiological Sciences, vol. 13, No. 8, pp. 1180-1184, 2014. [cited by applicant]
Johnston et al., “Biologically Active Polymers from Spontaneous Carotenoid Oxidation: A New Frontier in Carotenoid Activity”, Plos One, vol. 9, No. 10, pp. 1-10, Oct. 2014. [cited by applicant]
Jones et al., Compendium of Polymer Terminology and Nomenclature: IUPAC Recommendations 2008, International Union of Pure and Applied Chemistry, 20 pages, 2008. [cited by applicant]
Kolpashchikova et al., “Organic Chemistry Part II. Arenes. Halogened Hydrocarbons”, Ministry of Education of the Russian Federation, pp. 1-3, 1999. [cited by applicant]
Lam et al., “Synthesis of Dinucleating Phenanthroline-based Ligands”, Tetrahedron, vol. 55, No. 28, pp. 8377-8384, Jul. 9, 1999. [cited by applicant]
Latif et al., “Cleavage of Xanthene Ethers: a New Route to 9-substituted Xanthenes”, Canadian Journal of Chemistry, vol. 42, pp. 1736-1740, 1964. [cited by applicant]
Laxer, Michele, “Soft Tinted Contact Lenses and Color Discrimination”, International Contact Lens Clinic, vol. 17, pp. 88-91, Mar.-Apr. 1990. [cited by applicant]
Liu, Zhuo., “Tutorial on Modern Rock and Mineral Analytic Experiments”, Geological Press, p. 42, Oct. 31, 2015. [cited by applicant]
Luning et al., “Bimacrocylic 1,10-phenanthroline Cyclophanes”, Chemische Beri, vol. 123, No. 3, pp. 643-645, 1990. [cited by applicant]
Macleod et al., “Chromaticity Diagram Showing Cone Excitation by Stimuli of Equal Luminance”, Journal of the Optical Society of America, vol. 69, No. 8, pp. 1183-1186, Aug. 1979. [cited by applicant]
Mencucci et al., “Visual Outcome, Optical Quality and Patients' Satisfaction with a New Monofocal Intraocular Lens, Enhanced for Intermediate Vision: Preliminary Results”, Journal of Cataract and Refractive Surgery, vol… [cited by applicant]
Miao et al., “Objective Optical Quality and Intraocular Scattering in Myopic Adults”, Investigative Ophthalmology and Visual Science, vol. 55, No. 9, pp. 5582-5587, Sep. 2014. [cited by applicant]
Mostafa et al., “The Effect of Age and Gender on Tear Film Breakup Time”, Egyptian Journal of Medical Research, vol. 2, No. 2, 11 pages, 2021. [cited by applicant]
Nascimento et al., “Statistics of Spatial Cone-excitation Ratios in Natural Scenes”, Journal of the Optical Society of America A, vol. 19, No. 8, pp. 1484-1490, Aug. 2002. [cited by applicant]
Nishino et al., “Manganese (III)-Mediated Carbon-Carbon Bond Formation in the Reaction of Xanthenes with Active Methylene Compounds”, The Journal of Organic Chemistry, vol. 57, No. 13, pp. 3551-3557, Jan. 1, 1992. [cited by applicant]
Parraga et al., “Color and Luminance Information in Natural Scenes”, Journal of the Optical Society of America A, vol. 15, No. 3, pp. 563-569, Mar. 1998. [cited by applicant]
Patel et al., “Effect of Visual Display Unit Use on Blink Rate and Tear Stability”, Optometry & Vision Science, vol. 68, No. 11, pp. 888-892, 1991. [cited by applicant]
Pokorny et al., “Aging of the Human Lens”, Applied Optics, vol. 26, No. 8, pp. 1437-1440, Apr. 1987. [cited by applicant]
Reck et al., “Enantiopure Chiral Chiral Concave 1,10-phenanthrolines”, European Journal Of Organic Chemistry, vol. 2016, No. 6, pp. 1119-1131, 2016. [cited by applicant]
Ribeiro et al., “Antioxidant and Pro-oxidant Activities of Carotenoids and Their Oxidation Products”, Food and Chemical Toxicology, vol. 120, pp. 681-699, 2018. [cited by applicant]
Sato et al., “Synthesis and Characterization of Electron Transporting Polymers having Thioxanthene Derivatives”, Synthetic Metals, vol. 105, pp. 55-60, Jan. 1, 1999. [cited by applicant]
Selvam et al., “Tunable Anchoring Groups@acridone-linked Triphenylamine Based Pendant Chromophores and Their Effects on the Photovoltaic Performance as Sensitizers for Dye-sensitized Solar Cells”, RSC Advances, vol. 6, … [cited by applicant]
Stockman et al., “The Spectral Sensitivities of the Middle- and Long-wavelength-sensitive Cones Derived from Measurements in Observers of Known Genotype”, Vision Research, vol. 40, pp. 1711-1737, 2000. [cited by applicant]
Stringham et al., “Macular Pigment and Visual Performance in Glare: Benefits for Photostress Recovery, Disability Glare, and Visual Discomfort”, IOVS, vol. 52, No. 10, pp. 7406-7415, Sep. 2011. [cited by applicant]
Sutyagin et al., “Chemistry and Physics of Polymers”, Training Manual, Chapter 1, p. 9, Chapter 2, pp. 19-56, 2003. [cited by applicant]
Takeda et al., “Anisotropic Dissociation of p-p Stacking and Flipping-MotionInduced Crystal Jumping in Alkylacridones and Their Dicyanomethylene Derivatives”, Chemistry A European Journal, vol. 22, pp. 7763-7770, 2016. [cited by applicant]
Tan et al., “Dynamic Change of Optical Quality in Patients With Dry Eye Disease”, Invest Ophthalmol Vis Sci., vol. 56, No. 5, pp. 2848-2854, May 2015. [cited by applicant]
Tester et al., “Dysphotopsia in Phakic and Pseudophakic Patients: Incidence and Relation to Intraocular Lens Type”, Journal of Cataract & Refractive Surgery, vol. 26, No. 6, pp. 810-816, Jun. 2000. [cited by applicant]
Tsubota et al., “Dry Eyes and Video Display Terminals”, New England Journal of Medicine, vol. 328, No. 8, 584 page, Feb. 25, 1993. [cited by applicant]
Ty et al., “Oxidation and Thermal Degradation of Carotenoids”, Journal of Oil Palm Research, vol. II, No. 1, pp. 62-78, Jun. 1999. [cited by applicant]
Xi et al., “Assessment of Tear Film Optical Quality in a Young Short Tear Break-up Time Dry Eye: Case-control study”, Medicine, vol. 98, No. 40, pp. 1-6, 2019. [cited by applicant]