Granted Patent B2

US 12,734,073 · App. 18/536,674 · Granted Sep 15, 2026

Inventor: Catherine Shachaf (Los Gatos, CA)

A61F13/0259A61L15/22A61F2013/00097A61F2013/00285A61L2300/442A61L2300/45A61L2400/12

Abstract

Claims (29)

1 . A system comprising a patch and a fiducial marker, wherein the patch comprises:

(i) a substrate comprising silicone;

(ii) an adhesive on the substrate;

(iii) an opening in the substrate, and

(iv) a flap, wherein the flap covers the opening and is configured to allow introduction of a material in the patch; and

wherein the patch is configured to:

(a) attach to a skin via the adhesive to form a pocket between the patch and a skin, wherein the adhesive circumscribes the pocket, wherein the pocket is in contact with a skin of a user on the application of the patch on the skin;

(b) allow introduction of a material into the pocket through the opening, and

(c) hold the material within the pocket;

wherein the system is configured to image a portion of the skin on which the patch is placed.

2 . The system of claim 1 , wherein the patch further comprises a peelable liner.

3 . The system of claim 2 , wherein the peelable liner is attached to the patch via the adhesive.

4 . The system of claim 1 , wherein the material comprises a first material and a second material.

5 . The system of claim 4 , wherein the first material comprises a conditioning liquid.

6 . The system of claim 4 , wherein the second material comprises a dye.

7 . The system of claim 6 , wherein the activation of the material allows imaging of the skin.

8 . The system of claim 6 , wherein the dye comprises a fluorescent dye.

9 . The system of claim 4 , wherein the second material comprises an imaging agent.

10 . The system of claim 1 , wherein the patch is configured to allow introduction of the first material and the second material sequentially.

11 . The system of claim 1 , wherein the material is configured to activate by a radiation to allow reaction of an activated material with the skin.

12 . The system of claim 11 , wherein the radiation comprises an electromagnetic radiation.

13 . The system of claim 1 , wherein the flap comprises a composition same as the substrate.

14 . The system of claim 1 , wherein the flap comprises a composition different from the substrate.

15 . The system of claim 1 , wherein the pocket is prefilled with a third material.

16 . The system of claim 1 , wherein the opening comprises a tube or a clamp.

17 . The system of claim 16 , wherein the tube or the clamp comprises the flap.

18 . The system of claim 1 , wherein the patch is configured to hold the material for about 1 sec to about 5 mins.

19 . The system of claim 1 , wherein the substrate further comprises a stretchable material.

20 . The system of claim 1 , wherein the material is in a liquid form.

Continuity (2)

References Cited (17)