IP Library Granted Patent US 12,737,855
Granted Patent B2
US 12,737,855 · App. 18/840,391 · Granted Sep 15, 2026

Digital imaging system and method

Inventors: Raymond Jenoski (Boylston, MA); Randall Marks (Marlborough, MA)
Assignee: HOLOGIC, INC.
G06T5/70G06T5/50G06T7/50
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,737,855
App. No.
18/840,391
Granted
Sep 15, 2026
Kind
B2
Abstract

Methods and systems for providing multi-plane viewing of a digital image of a subject matter which do not require viewing multiple images taken at multiple image planes. Pseudo-focus images are generated from a flattened, merged image of a three-dimensional subject matter. The merged image is generated by merging a plurality of images taken at different focal planes of the subject matter which form a through-focus image stack. The merged image comprises the best focus pixels originating from different respective image planes. A depth map is also generated from the multiple images which associates each best focus pixel with a pixel depth value. A plane of interest (POI) is selected from the image planes. A pseudo-focus image is then generated using the merged image and pixel depth map by generating a blurred focus value for each best focus pixel based on the focus offset of each pixel from the POI.

Claims (28)

1 . A method for generating a pseudo-focus image of a digital image of a subject matter having a three-dimensional volume, comprising:

accessing: (1) a merged image of the subject matter having the three-dimensional volume, the merged image comprising an image generated from best focus pixels selected from a plurality of images of the subject matter which form a through-focus image stack, the best focus pixels originating from different respective image planes at different respective depths of the subject matter, each image plane being one of a plurality of image planes which stack up to form at least a partial depth of the subject matter; and (2) a pixel depth map associating each best focus pixel with a respective image plane corresponding to a depth value at which each best focus pixel originated within the subject matter;

selecting a first plane of interest (POI) from the plurality of image planes;

calculating a first pixel focus offset for each best focus pixel equal to a difference between a depth value of the first POI and the respective depth value for each best focus pixel;

generating a first blurred focus value for each best focus pixel based on the respective first pixel focus offset; and

generating a first pseudo-focus image of the merged image for the first POI composed of the first blurred focus values for each best focus pixel,

wherein generating the first blurred focus value for each best focus pixel based on the respective pixel focus offset, comprises:

generating a pixel focus offset array having a pixel focus offset for each best focus pixel equal to the difference between the depth value of the first POI and the respective depth value of each best focus pixel, the pixel focus offset array defining a range of pixel focus offsets within which a plurality of focus offset values are defined, and

generating a plurality of focus offset images corresponding to each first focus offset within the range of the pixel focus offset array by: (1) generating a blurred focus value for each of the focus offset values, and (2) for each focus offset value, applying a respective blurred focus value to the merged image, and

wherein generating the first pseudo-focus image of the merged image for the first POI composed of the first blurred focus values for each best focus pixel, comprises:

generating a focus mask for each image plane, wherein each focus mask contains all of the best focus pixels associated with the respective image plane; and

summing the products of (1) the focus mask for a respective image plane and (2) the focus offset image having the focus offset value corresponding to the respective image plane, for each image plane of the plurality of image planes.

2 . The method of claim 1 , further comprising:

displaying the first pseudo-focus image on a display device.

3 . The method of claim 2 , wherein the display device is selected from the group consisting of: an LCD display; an LED display; an OLED display; and a computer monitor.

4 . The method of claim 1 , further comprising:

selecting a second POI from the plurality of image planes different from the first POI;

calculating a second pixel focus offset for each best focus pixel equal to the difference between the depth value of the second POI and the respective depth value for each best focus pixel;

generating a second blurred focus value for each best focus pixel based on the respective second pixel focus offset; and

generating a second pseudo-focus image of the merged image for the second POI composed of the second blurred focus values for each best focus pixel.

5 . The method of claim 4 , further comprising:

displaying the second pseudo-focus image on a display device.

6 . The method of claim 1 , wherein the plurality of images of the subject matter used to generate the merged image are captured with a camera having an optical axis which is orthogonal to a slide surface to which the subject matter is affixed.

7 . The method of claim 1 , wherein the first blurred focus value for each best focus pixel is generated using a two-dimensional Gaussian blur function.

8 . The method of claim 7 , wherein two-dimensional Gaussian blur function utilizes a Gaussian blur radius based upon a depth of field of a camera system used to obtain the plurality of images of the subject matter.

9 . The method of claim 8 , wherein the Gaussian blur radius is also based upon an effective numerical aperture of the camera system.

10 . The method of claim 1 , wherein the merged image is an RGB digital image file and the pixel depth map is stored in a channel of RGB digital image file.

11 . The method of claim 1 , wherein the merged image is stored as a digital image file and the pixel depth map is stored in a separate file from the digital image file.

Assignments (5)
RELEASE OF SECURITY INTEREST RECORDED AT REEL/FRAME 069172/0436 Recorded Apr 28, 2026
From: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
To: HOLOGIC, INC.; GEN-PROBE INCORPORATED; FAXITRON BIOPTICS, LLC
Reel/Frame 075503/0086 →
SECURITY INTEREST Recorded Apr 8, 2026
From: BIOTHERANOSTICS, INC.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; CYTYC CORPORATION; SUROS SURGICAL SYSTEMS, INC.; GYNESONICS, INC.; BOLDER SURGICAL, LLC; FAXITRON BIOPTICS, LLC; HEALTH BEACONS, INC.; HOLOGIC, INC.
To: ROYAL BANK OF CANADA, AS COLLATERAL AGENT
Reel/Frame 075462/0440 →
SECURITY INTEREST Recorded Apr 8, 2026
From: BIOTHERANOSTICS, INC.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; CYTYC CORPORATION; SUROS SURGICAL SYSTEMS, INC.; GYNESONICS, INC.; BOLDER SURGICAL, LLC; FAXITRON BIOPTICS, LLC; HEALTH BEACONS, INC.; HOLOGIC, INC.
To: CITIBANK, N.A., AS COLLATERAL AGENT
Reel/Frame 075926/0339 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 1, 2024
From: JENOSKI, RAYMOND; MARKS, RANDALL
To: HOLOGIC, INC.
Reel/Frame 069110/0494 →
SECURITY INTEREST Recorded Oct 14, 2024
From: HOLOGIC, INC.; GEN-PROBE INCORPORATED; FAXITRON BIOPTICS, LLC
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 069172/0436 →
Continuity (2)
Provisional Application 63315041 · Feb 28, 2022
Related Publication 20250139746A1 · May 1, 2025
References Cited (11)
US 6025099A · Slonaker · 2000 [cited by examiner]
US 20150205126A1 · Schowengerdt · 2015 [cited by examiner]
US 20170311800A1 · Wang · 2017 [cited by examiner]
International Search Report and Written Opinion mailed Jun. 21, 2023, issued in corresponding International Patent Application No. PCT/US2023/063289, 10 pages. [cited by applicant]
Sakurikar Parikshit et al: “Focal Stack Representation and Focus Manipulation”, 2017 4th IAPR Asian Conference On Pattern, Recognition (ACPR), IEEE, Nov. 26, 2017 (Nov. 26, 2017), pp. 250-255, XP033475263, DOI: 10.1109/… [cited by applicant]
Giusti A et al: “Artificial Defocus for Displaying Markers in Microscopy Z-Stacks”, IEEE Transactions On Visualization and Computer Graphics, IEEE, USA, vol. 17, No. 12, Dec. 2011 (Dec. 2011), pp. 1757-1764, XP011444629… [cited by applicant]
Peter Bankhead: “Analyzing fluorescence microscopy images with ImageJ”, May 2014 (May 2014), XP055450084, Retrieved from the Internet: URL:https://blogs.qub.ac.uk/ccbg/files/2014/05/2014-05_Analyzing_fluorescence_micros… [cited by applicant]
David E Jacobs et al: “Focal Stack Compositing for Depth of Field Control”, Jan. 31, 2012 (Jan. 31, 2012), XP055654614, URL: https://graphics.stanford.edu/papers/focalstack/focalstack.pdf. [cited by applicant]
European Office Action dated Mar. 18, 2026, for EP Application No. 25223120.4, filed Feb. 24, 2023; 8 pages total. [cited by applicant]
European Office Action dated Jul. 24, 2025, for EP Application No. 23713542.1, filed Feb. 24, 2023; 8 pages total. [cited by applicant]
Australian Examination Report No. 1 dated Feb. 26, 2026, for AU Application No. 2023224291, filed Feb. 24, 2023; 3 pages total. [cited by applicant]