Granted Patent B2

US 12,740,800 · App. 17/642,784 · Granted Sep 22, 2026

Inventor: Aseem Singh (Tempe, AZ)

Assignee: Bard Peripheral Vascular, Inc.

A61B17/320068A61B17/3203A61B2017/32032

Abstract

Claims (61)

1 . An ultrasonic probe assembly, comprising:

an ultrasonic transmission member having a first end portion and a second end spaced apart from the first end portion;

a cannula having a tubular side wall, a cannula lumen, an annular protrusion, a fluid input port, a proximal end, a distal end, and a distal end portion; and

a fluid source;

a fluid conduit coupling the fluid input port to the fluid source such that the fluid input port is configured to receive a flow of liquid from the fluid source,

wherein:

the ultrasonic transmission member is located in the cannula lumen;

the fluid input port of the cannula is connected in fluid communication with the cannula lumen;

the distal end portion of the cannula is configured to define a cavitation generation chamber, the cavitation generation chamber having a distal end wall at the distal end of the cannula, wherein the distal end wall comprises a sieve defining a plurality of apertures configured to eject fluid jetting streams along a longitudinal direction of the cannula, wherein each aperture of the plurality of apertures has an aperture axis that is parallel to a longitudinal axis of the cannula;

the second end of the ultrasonic transmission member distally terminates at a location proximal to the cavitation generation chamber; and

the annular protrusion extends inwardly from the tubular side wall into the cannula lumen and is configured to define:

a termination end of the cannula lumen; and

an aft end of the cavitation generation chamber.

2 . The ultrasonic probe assembly according to claim 1 , wherein the longitudinal axis of the cannula extends through each of the cannula lumen, the cavitation generation chamber, and the sieve.

3 . The ultrasonic probe assembly according to claim 1 , wherein the cannula is made of a biocompatible metal.

4 . The ultrasonic probe assembly according to claim 1 , further comprising a cannula sheath having a microtube arrangement that surrounds the tubular side wall of the cannula in a region proximal to the cavitation generation chamber, wherein the microtube arrangement is configured to receive a flow of a cooling fluid.

5 . The ultrasonic probe assembly according to claim 4 , wherein the cannula sheath is attached to the cannula.

6 . The ultrasonic probe assembly of claim 1 , wherein:

the distal end wall is planar and perpendicular to the longitudinal axis of the cannula; and

the plurality of apertures comprises a plurality of linear aperture arrays that are parallel to one another.

7 . The ultrasonic probe assembly of claim 1 , wherein the plurality of apertures are uniformly sized.

8 . The ultrasonic probe assembly of claim 1 , wherein the annular protrusion is positioned distally with respect to a termination end of the ultrasonic transmission member.

9 . The ultrasonic probe assembly of claim 1 , wherein the cavitation generation chamber has a length along the longitudinal axis of the cannula that is greater than a diameter of the cavitation generation chamber.

10 . An ultrasonic microcavitation device, comprising:

a handle containing an ultrasonic transducer;

an ultrasonic transmission member having a first end portion and a second end spaced apart from the first end portion, wherein the first end portion of the ultrasonic transmission member is connected to the ultrasonic transducer;

a cannula connected to the handle, the cannula having a tubular side wall, a cannula lumen, an annular protrusion, a fluid input port, a proximal end, a distal end, and a distal end portion;

a fluid source; and

a fluid conduit coupling the fluid input port to the fluid source such that the fluid input port is configured to receive a flow of liquid from the fluid source,

wherein:

the ultrasonic transmission member is located in the cannula lumen;

the fluid input port of the cannula is connected in fluid communication with the cannula lumen;

the distal end portion of the cannula is configured to define a cavitation generation chamber that distally terminates at the distal end of the cannula, the cavitation generation chamber having a distal end wall comprising a sieve defining a plurality of apertures configured to eject fluid jetting streams along a longitudinal direction of the cannula, wherein each aperture of the plurality of apertures has an aperture axis that is parallel to a longitudinal axis of the cannula;

the second end of the ultrasonic transmission member distally terminates at a location proximal to the cavitation generation chamber; and

the annular protrusion extends inwardly from the tubular side wall into the cannula lumen and is configured to define:

a termination end of the cannula lumen; and

an aft end of the cavitation generation chamber.

11 . The ultrasonic microcavitation device according to claim 10 , wherein the longitudinal axis of the cannula extends through each of the cannula lumen, the cavitation generation chamber, and the sieve.

12 . The ultrasonic microcavitation device according to claim 10 , further comprising a microtube arrangement that surrounds the tubular side wall of the cannula in a region proximal to the cavitation generation chamber, wherein the microtube arrangement is configured to receive a flow of a cooling fluid.

13 . The ultrasonic microcavitation device according to claim 10 , wherein the cannula is made of a biocompatible metal.

14 . A microcavitation system, comprising:

a console having an ultrasonic signal generator and a fluid source;

a handle containing an ultrasonic transducer, wherein the ultrasonic transducer is electrically connected to the ultrasonic signal generator;

an ultrasonic transmission member having a first end portion and a second end spaced apart from the first end portion, wherein the first end portion of the ultrasonic transmission member is mechanically connected to the ultrasonic transducer; and

a cannula connected to the handle, the cannula having a tubular side wall, a cannula lumen, an annular protrusion, a fluid input port, a proximal end, a distal end, and a distal end portion that is configured to define a cavitation generation chamber that distally terminates at the distal end,

wherein:

the ultrasonic transmission member is located in the cannula lumen;

the fluid input port of the cannula is connected in fluid communication with the fluid source to receive a flow of a fluid from the fluid source;

the fluid input port of the cannula is connected in fluid communication with the cannula lumen, wherein the fluid is supplied through the cannula lumen to the cavitation generation chamber;

the cavitation generation chamber of the cannula has a distal end wall comprising a sieve defining a plurality of apertures configured to eject fluid jetting streams along a longitudinal direction of the cannula, wherein each aperture of the plurality of apertures has an aperture axis that is parallel to a longitudinal axis of the cannula;

the second end of the ultrasonic transmission member distally terminates at a location proximal to the cavitation generation chamber; and

the annular protrusion extends inwardly from the tubular side wall into the cannula lumen and is configured to define:

a termination end of the cannula lumen; and

an aft end of the cavitation generation chamber.

15 . The microcavitation system according to claim 14 , wherein the longitudinal axis of the cannula extends through each of the cannula lumen, the cavitation generation chamber, and the sieve.

16 . The microcavitation system according to claim 14 , wherein the cannula is made of a biocompatible metal.

17 . The microcavitation system according to claim 14 , further comprising a microtube arrangement that surrounds the tubular side wall of the cannula in a region proximal to the cavitation generation chamber, wherein the microtube arrangement is configured to receive the flow of the fluid from the fluid source to cool the cannula.

18 . The microcavitation system according to claim 14 , wherein the console further includes a user interface and a controller, the controller being communicatively coupled to each of the user interface, the ultrasonic signal generator, and the fluid source, the controller configured to execute program instructions to:

process an input signal from the user interface;

provide a first output control signal to the ultrasonic signal generator to cause the ultrasonic signal generator to generate an ultrasonic excitation signal having an electrical energy output level, the ultrasonic excitation signal being supplied to the ultrasonic transducer, wherein the ultrasonic transducer generates vibratory energy at a vibratory energy level corresponding to the electrical energy output level of the ultrasonic excitation signal; and

provide a second output control signal to the fluid source to control an amount of flow of a fluid generated by the fluid source, the fluid source supplying the flow of fluid to the fluid input port of the cannula.

Assignments (1)

Continuity (1)

References Cited (23)