Granted Patent
B2
US 12,740,942 · App. 18/424,973 · Granted Sep 22, 2026
Surface treatment of contact lens and treatment of ocular discomfort by water soluble polymers and lipids/liposomes
Assignee:
Yeda Research and Development Co. Ltd.
A61K9/127A61K9/0048A61K9/08A61K31/728A61K31/77A61K31/79A61K47/10A61K47/32A61K47/36B65D35/00B65D75/36
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Abstract
Formulations (e.g., solutions) comprising one or more water-soluble polymer(s), liposomes, and an aqueous carrier, are provided. The provided solutions are useful for rinsing, and/or immersing therein, a contact lens and/or in the treatment of ocular discomfort, for example, an ocular discomfort associated with a contact lens. Also provided are kits comprising the solution and a contact lens; articles-of-manufacturing comprising the solution and configured for dispending the solution; and methods utilizing the solution.
Claims (29)
1 . A method of reducing a friction coefficient of a surface of a contact lens, the method comprising rinsing and/or immersing the contact lens in a solution comprising at least one water-soluble polymer, liposomes, and an aqueous carrier, wherein a concentration of phospholipids of said liposomes in the solution is in a range of from 0.5 mM to 500 mM.
2 . The method of claim 1 , wherein said contact lens comprises a hydrogel surface.
3 . The method of claim 1 , wherein said at least one water-soluble polymer comprises an ionic polymer.
4 . The method of claim 3 , wherein said ionic polymer is an anionic polymer.
5 . The method of claim 4 , wherein said anionic polymer is hyaluronic acid.
6 . The method of claim 3 , wherein said liposomes are characterized by a surface charge having a sign opposite a sign of a net charge of said ionic polymer.
7 . The method of claim 1 , wherein a molar percentage of phosphatidylcholine in said liposomes is at least 50%.
8 . The method of claim 1 , wherein said carrier is an ophthalmically acceptable carrier.
9 . A kit comprising at least one contact lens and a solution comprising at least one water-soluble polymer, liposomes, and an aqueous carrier, wherein a concentration of phospholipids of said liposomes in the solution is in a range of from 0.5 mM to 500 mM.
10 . The kit of claim 9 , wherein said contact lens comprises a hydrogel surface.
11 . The kit of claim 9 , wherein said at least one water-soluble polymer comprises an ionic polymer.
12 . The kit of claim 11 , wherein said ionic polymer is an anionic polymer.
13 . The kit of claim 12 , wherein said anionic polymer is hyaluronic acid.
14 . The kit of claim 11 , wherein said liposomes are characterized by a surface charge having a sign opposite a sign of a net charge of said ionic polymer.
15 . The kit of claim 9 , wherein a molar percentage of phosphatidylcholine in said liposomes is at least 50%.
16 . The kit of claim 9 , wherein said carrier is an ophthalmically acceptable carrier.
17 . The kit of claim 16 , wherein said at least one contact lens and said solution are packaged separately.
18 . The kit of claim 17 , wherein said solution is separately packaged in a container configured for dispensing the solution.
19 . The kit of claim 9 , wherein said contact lens is immersed in said solution.
20 . A method of treating ocular discomfort in a subject in need thereof, the method comprising ophthalmically administering to the subject an effective amount of a solution comprising at least one water-soluble polymer, liposomes, and an aqueous carrier, wherein a concentration of phospholipids of said liposomes in the solution is in a range of from 0.5 mM to 500 mM.
21 . The method of claim 20 , wherein said at least one water-soluble polymer comprises a non-ionic polymer.
22 . The method of claim 20 , wherein said at least one water-soluble polymer comprises an ionic polymer.
23 . The method of claim 22 , wherein said ionic polymer has from 1 to 6 charged groups per 1 kDa.
24 . The method of claim 22 , wherein said ionic polymer is an anionic polymer.
25 . The method of claim 24 , wherein said anionic polymer is hyaluronic acid.
26 . The method of claim 22 , wherein said liposomes are characterized by a surface charge having a sign opposite a sign of a net charge of said ionic polymer.
27 . The method of claim 20 , wherein a molar percentage of phosphatidylcholine in said liposomes is at least 50%.
28 . The method of claim 20 , wherein said carrier is an ophthalmically acceptable carrier.
29 . The method of claim 20 , wherein said ocular discomfort is associated with a contact lens.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Apr 23, 2024
From: KLEIN, JACOB; GOLDBERG, RONIT; SEROR, JASMINE
To: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Reel/Frame 067187/0393 →
Continuity (3)
Provisional Application
62012379
· Jun 15, 2014
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