Composition containing homoharringtonine as active ingredient for preventing or treating muscle diseases
The present invention relates to a composition for preventing or treating muscle diseases, wherein the composition contains homoharringtonine as an active ingredient, wherein it was found that the suppression of a decrease in skeletal muscle mass and improved muscle strength were exhibited in an experimental group in which homoharringtonine was administered to an animal model in which reduction in muscle mass and muscular atrophy were induced by obesity, aging, or the fixing of lower extremities, and thus the composition including homoharringtonine as an active ingredient can be provided as a pharmaceutical composition or a health food for preventing or treating muscle diseases caused by a decrease in muscle mass or muscle strength.
1 . A method of treating a muscle disease, comprising:
administering a pharmaceutical composition comprising homoharringtonine as an active ingredient to a subject having the muscle disease,
wherein the muscle disease is sarcopenia or muscular atrophy, and
wherein the homoharringtonine attenuates a reduction in skeletal muscle mass in the subject.
2 . The method of claim 1 , wherein the sarcopenia or the muscular atrophy is caused by at least one selected from the group consisting of obesity, aging, and lower limb fixation.
3 . The method of claim 1 , wherein the pharmaceutical composition comprises 0.01 to 10 parts by weight of homoharringtonine with respect to a total of 100 parts by weight of the pharmaceutical composition.
4 . The method of claim 1 , wherein the homoharringtonine further increases muscle strength without a change in body weight of the subject.
5 . A method of ameliorating a muscle disease, comprising:
administering a health food comprising homoharringtonine as an active ingredient to a subject having the muscle disease,
wherein the muscle disease is sarcopenia or muscular atrophy, and
wherein the homoharringtonine attenuates a reduction in skeletal muscle mass in the subject.
6 . The method of claim 5 , wherein the sarcopenia or the muscular atrophy is caused by at least one selected from the group consisting of obesity, aging, and lower limb fixation.