Granted Patent B2

US 12,749,197 · App. 19/127,392 · Granted Sep 29, 2026

Inventors: Andrew John Healey (Moss, NO); Svein Kvåle (Ås, NO); Ola Myhre (Haslum, NO)

Assignee: Exact Therapeutics AS

G06T7/11A61B8/06A61B8/4245A61B8/469A61B8/481A61B8/5207G06T7/0012G06T2207/10081G06T2207/10088G06T2207/10132G06T2207/30008G06T2207/30024G06T2207/30104

Abstract

Claims (82)

1 . A system for providing a point estimate of an ultrasound dose at a region of interest in a subject comprising:

an ultrasound source;

an image processor module for processing images to identify different components of the region of interest;

a computer processor;

a database module comprising medium property values associated with a plurality of categories for components within the region of interest;

a data storage module comprising computer readable instruction that when executed on the processor perform the tasks of:

retrieving an image of the region of interest, wherein the region of interest comprises a target treatment area and a surrounding region of the target treatment area;

processing the image to identify different components of the region of interest;

segmenting and categorizing the different components into predetermined media categories;

retrieving a medium property value associated with each media category, comprising;

estimating a category-specific ultrasound coupling bubble element correction to the medium property value resulting from the presence of at least one ultrasound coupling bubble element in at least one component; and

adjusting the medium property value of the at least one component to account for the respective category-specific ultrasound coupling bubble element correction; and

attributing said medium property value to each respective component of the segmented region of interest; and

delineating an ultrasound propagation path from the ultrasound source to the target treatment region;

compiling the medium property values for each component over the propagation path to calculate an ultrasound propagation correction factor unique to the ultrasound propagation path through the region of interest;

calculating the point estimate of the ultrasound dose at the region of interest based on the unique propagation correction factor; and

adjusting the ultrasound source according to the calculated point estimate of the ultrasound dose if outside of a predetermined ultrasound dose range.

2 . The system of claim 1 , wherein the image processor is configured to segment and categorize the different components of the region of interest by:

identifying boundaries between different patterns of the image;

analyzing the pattern within the boundaries; and

comparing each of the patterns to image patterns of known tissue type to find a match.

3 . The system of claim 2 , wherein the system is a machine learning system and wherein each processed image, along with associated image data, is accumulated as training data to provide more accurate segmentation and categorization by the image processor over time.

4 . The system of claim 1 , further comprising an ultrasound probe providing the ultrasound source, the system further configured to:

track the ultrasound probe position;

re-evaluate one or more propagation correction factors with movement of the ultrasound probe position; and

store a one or more propagation correction factors per ultrasound probe position to reduce a computational load.

5 . The system of claim 1 , further configured to:

track an in-plane and out-of-plane rhythmic movement of the medium of the region of interest;

re-evaluate one or more propagation correction factors for each in-plane and out-of-plane position of the moving medium; and

store the one or more propagation correction factors for each in-plane and out-of-plane position of the moving medium.

6 . The system of claim 5 , wherein the system is configured to track the in-plane and out-of-plane rhythmic movement of the medium through speckle-tracking or machine learning algorithms.

7 . The system of claim 1 , wherein the media categories comprise at least one of:

different tissue types;

different tissue types afflicted by one or more particular diseases;

a fluid; and

a gas.

8 . The system of claim 7 , wherein the different tissue types comprise one or more of:

soft tissue comprising fat, muscle, parenchyma, tendons and ligaments; and

hard tissue comprising bone.

9 . The system of claim 8 , wherein calculating the correction resulting from the presence of contrast agent in each category is based on contrast mode imaging ultrasound.

10 . The system of claim 7 , wherein the at least one ultrasound coupling bubble element comprises ACT bubble technology ultrasound coupling bubble elements and wherein calculating an additional ACT bubble correction comprises:

estimating additional correction resulting from ACT microbubble clusters in the presence of the high frequency activation ultrasound;

estimating additional correction resulting from generated ACT bubbles in the presence of the high frequency activation ultrasound; and

estimating additional correction resulting from ACT bubbles in the presence of low frequency enhancement ultrasound.

11 . The system of claim 10 , wherein calculating additional ACT bubble correction further comprises:

estimating a number of ACT bubbles in the categories associated with each component by:

retrieving or estimating one or more ACT bubble parameters, wherein the ACT bubble parameters comprise:

a blood volume of the subject;

a cardiac output of the subject;

a perfusion of each category of components; and

a time concentration curve; and

calculating the number of ACT bubbles delivered to each of the components by multiplying a fraction of the cardiac output that accounts for the perfusion of each category of components by a yield of activation of ACT bubble clusters.

12 . The system of claim 11 , wherein the estimation of the number of ACT bubbles in the categories associated with each segment comprises a time dependency by:

retrieving a value for a lifetime of an ACT bubble in each category to model a reduction of the number of ACT bubbles in each category over time.

13 . The system of claim 1 , wherein the retrieving the image of the region of interest comprises at least one of:

retrieving a pre-scanned scan of the region of interest;

taking a pre-scan scan of the region of interest; and

using a real-time diagnostic imaging system image.

14 . The system of claim 13 , wherein the scan comprises one or more of:

a computer tomography image; and

a magnetic resonance image.

15 . The system of claim 14 , wherein calculating the additional correction resulting from the presence of ACT bubbles in each category is based on fundamental B-mode imaging ultrasound.

16 . The system of claim 13 , wherein the at least one ultrasound coupling bubble element comprises one or more of:

contrast agent microbubbles;

cavitation seeds;

large microbubbles;

acoustic cluster therapy (ACT) bubble technology ultrasound coupling bubble elements, wherein the ACT bubble technology ultrasound coupling bubble elements comprise:

ACT microbubble clusters; and

activated ACT bubbles.

17 . The system of claim 16 , wherein the at least one ultrasound coupling bubble element comprises contrast agent microbubbles and wherein estimating a contrast agent microbubble correction comprises:

retrieving or estimating contrast agent microbubble parameters, wherein the contrast agent microbubble parameters comprise:

a value for the dose of contrast agent microbubbles administered;

contrast agent attenuation per unit concentration;

a blood volume of the subject;

a cardiac output of the subject;

a value of blood volume associated with each category;

arrival times after intravenous administration of the contrast agent for each category; and

a time concentration curve; and

using the contrast agent parameters to calculate the contrast agent correction for each category.

18 . The system of claim 1 , further comprising using the unique propagation correction factor to calculate at least one of a resulting pressure, a resulting mechanical index, a resulting intensity, a resulting power and a resulting thermal index, which are indications of delivered ultrasound dose.

19 . The system of claim 1 , wherein the medium property comprises at least one of attenuation, sound speed, shear wave velocity, acoustic impedance, coefficients of non-linear compressibility, and coefficients of dispersion.

20 . The system of claim 19 , wherein the medium property further comprises one or more derived properties that can be derived from any one, or any combination, of the medium properties listed.

Assignments (1)

Priority Claims (1)

Continuity (1)

References Cited (139)