Sensor array using sail
View Patent ↗Provided is a sensor array and a method of forming the same. The sensor array includes an array of apertures etched into a 3D patterned resist layer to expose areas of one or more agents and/or reagents deposited on a substrate. The sensor is formed using a Self-Aligned Imprint Lithography (“SAIL”) method, a process that allows for a one-time deposition of all required materials followed by a series of etching/cleaning steps. The location of reagents on the sensor template, as well as the concentration gradient of each reagent, may be controlled through the sensor manufacturing process. Bores of a single reagent, or bores containing two or more reagents, may be formed using the SAIL process.
1. A method of forming a sensor array comprising:
providing a substrate;
disposing one or more reagents upon the substrate;
depositing at least one resist layer over the one or more reagents;
establishing a three-dimensional masking structure in the resist layer having a plurality of different vertical heights; and
etching the three-dimensional structure to expose portions of the one or more reagents in a plurality of separated apertures.
2. The method of claim 1 , wherein the substrate is flexible.
3. The method of claim 1 , wherein the etching is an anisotropic etch.
4. The method of claim 1 which includes self-aligning, imprint lithography.
5. The method of claim 1 further comprising imprinting a single polymer resist layer with a three-dimensional template to establish patterning and alignment of the three-dimensional structure for etching.
6. The method of claim 1 , wherein the one or more reagents are biological reagents.
7. The method of claim 1 , wherein a plurality of different reagents are deposited on the substrate according to a predetermined pattern, at least a portion of the pattern exposed in one or more apertures.
8. The method of claim 1 , wherein a concentration of a given reagent on the substrate varies according to a predetermined pattern, the concentration of the given reagent exposed in at least one aperture being different from the concentration of the same given reagent exposed in at least one other aperture.
9. The method of claim 1 , wherein the sensor array is in electrical contact with at least one thin-film device.
10. The method of claim 9 , wherein forming the thin-film device comprises:
providing a substrate;
depositing a plurality of thin-film device layers upon the substrate;
providing an imprinted three-dimensional masking structure upon the plurality of thin film device layers;
etching the three-dimensional structure and plurality of thin-film device layers; and undercutting at least one thin-film device layer.
11. The method of claim 9 , wherein the thin-film device is a rectifying device selected from the group consisting of a diode, a junction or a transistor.
12. The method of claim 9 , wherein the thin-film device is a micro-electromechanical device.
13. The method of claim 9 further comprising providing a plurality of thin-film devices to form an active matrix backplane.
14. A method of testing for one or more chemical reactions using an active sensor array comprising:
providing a substrate in electrical contact with one or more thin-film devices;
disposing one or more reagents upon the substrate;
depositing a resist layer over the one or more reagents;
establishing a three-dimensional masking structure in the resist layer having a plurality of different vertical heights;
etching the three-dimensional structure to create a plurality of separated apertures exposing portions of the one or more reagents;
introducing a test material into the plurality of apertures; and
detecting and measuring at least one electrical output generated by a chemical reaction between the one or more reagents and the test material.
15. The method of claim 14 , wherein the test material includes a plurality of substances detectable by the one or more reagents.
16. The method of claim 14 , wherein the thin-film device is a rectifying device selected from the group consisting of: a diode, a junction or a transistor.