IP Library › Granted Patent US 7,791,728
Granted Patent B2
US 7,791,728 · App. 11/201,983 · Granted Sep 7, 2010

System for optically analyzing a substance with a selected single-wavelength

Assignee: Hewlett-Packard Development Company, L.P.
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Quick Facts
Patent No.
US 7,791,728
App. No.
11/201,983
Granted
Sep 7, 2010
Kind
B2
Abstract

A microfluidic analysis system for optically analyzing a substance includes a light source having a plurality of selectable single-wavelength light sources, a substance presentation member optically coupled to the light source, and an optical detection system associated with the substance presentation member.

Claims (27)

1. A method of using a light source carousel including a plurality of selectable single-wavelength light sources, comprising:

selecting a desired single-wavelength light source from said plurality of selectable single-wavelength light sources;

illuminating an analyte with said desired single-wavelength light source; and

detecting a wavelength associated with said analyte when illuminated by said selected single-wavelength;

said selecting of the desired single-wavelength light source being accomplished by rotating said carousel which supports said plurality of single-wavelength light sources so as to optically couple one of said light source with said analyte, and rotating a micro-fluidic disk bearing said analyte to position said analyte for illumination;

wherein said carousel bearing said light sources and said micro-fluidic disk are concentric and rotate on a common axis.

2. The method of claim 1 , wherein said selecting a desired single-wavelength light source from said plurality of selectable single-wavelength light sources is at least partially based on an absorption or emission characteristic of said analyte.

3. The method of claim 1 , wherein said selecting a desired single-wavelength light source from said plurality of selectable single-wavelength light sources comprises:

identifying a peak or plateau in an absorption or emission spectrum of said analyte; and

selecting a single-wavelength light source with a radiation wavelength associated with said absorption or emission spectrum peak or plateau.

4. The method of claim 1 , further comprising:

illuminating a plurality of analytes simultaneously with said plurality of selectable single-wavelength light sources; and

simultaneously detecting wavelengths associated with said plurality of illuminated analytes.

5. The method of claim 4 , wherein said simultaneously detecting wavelengths associated with said plurality of illuminated analytes comprises detecting said wavelengths with a charge coupled device.

6. The method of claim 1 , wherein there is a one-to-one correspondence between said plurality of light sources and cuvettes on said micro-fluidic disk.

7. The method of claim 1 , further comprising additionally rotating said carousel to optically couple said analyte to a series of said light sources, in which said light sources emit different wavelengths of light.

8. The method of claim 1 , wherein selecting a desired single-wavelength light source comprises translating a substrate bearing said plurality of light sources with respect to said analyte so as to optically couple a selected light source with said analyte.

9. The method of claim 1 , further comprising using a light pipe to optically couple said plurality of light sources with said analyte.

10. A method of using a light source carousel including a plurality of selectable single-wavelength light sources to analyze number of analytes, said method comprising:

rotating said carousel which supports said plurality of single-wavelength light sources so as to optically couple one of said light sources with said analytes;

rotating a micro-fluidic disk bearing said analytes in a number of cuvettes defined in the micro-fluidic disk to position said analytes for illumination;

illuminating said analytes with said optically coupled light source; and

detecting light from said illuminated analytes,

in which there is a one-to-one correspondence between said plurality of light sources and cuvettes on said micro-fluidic disk.

11. The method of claim 10 , wherein said carousel bearing said light sources and said micro-fluidic disk are concentric and rotate on a common axis.

12. The method of claim 10 , further comprising additionally rotating said carousel to optically couple said analyte to a series of said light sources, in which said light sources emit different wavelengths of light.

13. The method of claim 10 , wherein detecting light from said illuminated analyte further comprises detecting analyte chemical reaction products in said sample of said analyte.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 11, 2005
From: BEATTY, CHRISTOPHER C.; HARDING, PHILIP; DUDENHOEFER, CHRISTIE; OTIS, CHARLES
To: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Reel/Frame 016892/0547 →
Continuity (1)
Related Publication 20070037272A1 · Feb 15, 2007