8-{4-[3-(5-fluoro-1H-indol-3-yl)-propyl]-piperazin-1-yl}-2-methyl-4H-benzo[1,4]oxazin-3-one mesylate with high affinity for the dopamine D
The invention relates to the novel mesylate of a phenylpiperazine derivative of the formula (I). This salt has a favorable properties as compared with the free base of this compound.
1. A method of preparing a pharmaceutical composition comprising combining an effective amount of at least one compound of the formula:
with at least one auxiliary substance.
2. The method of preparing a pharmaceutical composition as set forth in claim 1 , wherein at least one compound comprises the R enantiomer.
3. The method of preparing a pharmaceutical composition as set forth in claim 1 , wherein at least one compound comprises the S enantiomer.
4. The method of preparing a pharmaceutical composition as set forth in claim 1 , wherein the composition comprises both the R enantiomer and the S enantiomer of at least one compound.
5. The method of preparing a pharmaceutical composition as set forth in claim 1 , wherein at least one auxiliary substance comprises a solid carrier.
6. The method of preparing a pharmaceutical composition as set forth in claim 1 , wherein the at least one auxiliary substance comprises a liquid carrier.
7. A compound of the formula:
8. A compound of the formula: