Granted Patent B2

US 8,309,565 · App. 13/220,548 · Granted Nov 13, 2012

Assignee: The Regents of the University of California

Abstract

Claims (42)

1. An antiviral compound having the structure of Formula I:

wherein

R 2 , R 2 ′, R 1′ are each independently hydrogen;

R 1 is —O—(C 1 -C 24 )alkyl;

m is an integer from 0 to 6;

n is 0; and

or a pharmaceutically acceptable salt or a stereochemically isomeric form thereof.

2. The compound of claim 1 , wherein m is 2 or 3.

3. The compound of claim 1 , wherein R 1 is —O(C 15 )alkyl or —O(C 17 )alkyl.

4. The compound of claim 1 , wherein the compound is selected from the group consisting of

or a pharmaceutically acceptable salt thereof.

5. A pharmaceutical composition comprising an effective amount of an antiviral compound of Formula I

wherein

R 2 , R 2 ′, R 1′ are each independently hydrogen;

R 1 is —O—(C 1 -C 24 )alkyl;

m is an integer from 0 to 6;

n is 0; and

or a pharmaceutically acceptable salt thereof;

in combination with a pharmaceutically acceptable carrier.

6. The pharmaceutical composition of claim 5 , wherein the composition is in a solid dosage form, capsule, tablet, aerosol, solution, suspension, or in a topical formulation.

7. The pharmaceutical composition of claim 5 , wherein the compound is selected from the group consisting of

or a pharmaceutically acceptable salt thereof.

8. A method for the treatment of a viral disease comprising administering an effective amount of an antiviral compound of Formula I

wherein

R 2 , R 2 ′, R 1′ are each independently hydrogen;

R 1 is —O—(C 1 -C 24 )alkyl;

m is an integer from 0 to 6;

n is 0; and

or a pharmaceutically acceptable salt thereof;

optionally in a pharmaceutically acceptable carrier.

9. The method of claim 8 , wherein the viral disease is selected from the group consisting of human immunodeficiency virus, influenza, herpes simplex virus, human herpes virus, cytomegalovirus, hepatitis B and C virus, Epstein-Barr virus, varicella zoster virus, orthopox virus, ebola virus and papilloma virus.

10. The method of claim 9 , wherein the orthopox is selected from variola major and minor, vaccinia, smallpox, cowpox, camelpox and monkeypox.

11. The method of claim 8 , wherein the virus is HIV.

12. The method of claim 8 , wherein the virus is influenza.

13. The method of claim 8 , wherein the virus is herpes.

14. The method of claim 8 , wherein the virus is cytomegalovirus.

15. The method of claim 8 , wherein the virus is hepatitis B or hepatitis C.

16. The method of claim 8 , wherein the virus is Epstein-Barr virus.

17. The method of claim 8 , wherein the virus is varicella zoster virus.

18. The method of claim 8 , wherein the virus is papilloma.

19. The method of claim 8 , wherein the compound is selected from the group consisting of

or a pharmaceutically acceptable salt thereof.

Assignments (1)

Continuity (10)