Compositions and methods for inducing bone growth and inhibiting bone loss
View Patent ↗Compositions useful for inducing bone growth or inhibiting bone loss in an animal comprising one or more isoflavones or isoflavone metabolites and methods for inducing bone growth or inhibiting bone loss in an animal utilizing such compositions. The compositions and methods are particularly useful for post-menopause, post-andropause, gonadectomized, spayed, or neutered animals.
1. A composition comprising one or more isoflavones or metabolites thereof in an amount effective to induce bone growth in an animal, further comprising at least one of DT56a, androstenedione, dehydroepiandrosterone (DHEA), silicon, L-carnitine, conjugated linoleic acid, and orthosilicic acid.
2. The composition of claim 1 wherein the composition is a human food composition, pet food composition, or a dietary supplement.
3. The food composition of claim 2 wherein the food composition comprises from about 0.1% to about 50% isoflavones or metabolites thereof.
4. The composition of claim 1 wherein the isoflavones include at least one of daidzein, 6-O-malonyl daidzein, 6-O-acetyl daidzein, genistein, 6-O-malonyl genistein, 6-O-acetyl genistein, glycitein, 6-O-malonyl glycitein, 6-O-acetyl glycitein, biochanin A, or formononetin.
5. The composition of claim 1 wherein the isoflavones or metabolites thereof are soy isoflavones or metabolites thereof.
6. The composition of claim 5 wherein the soy isoflavone metabolite is equol.
7. The composition of claim 1 wherein the animal is a post-menopause, post-andropause, gonadectomized, spayed, or neutered animal.
8. A kit suitable for administering a composition comprising one or more isoflavones or metabolites thereof to an animal comprising in separate containers in a single package or in separate containers in a virtual package, one or more isoflavones or metabolites thereof and at least one of (1) one or more ingredients suitable for consumption by an animal, (2) one or more bone affecting agents selected from DT56a, androstenedione, dehydroepiandrosterone (DHEA), silicon, L-carnitine, conjugated linoleic acid, and orthosilicic acid, (3) instructions for how to combine the isoflavones or metabolites thereof and other kit components, and (4) instructions for how to use the isoflavones or metabolites thereof and other components to induce bone growth in the animal.
9. The composition of claim 1 , formulated for administration to a young or growing animal.
10. The composition of claim 9 , formulated as a puppy food or kitten food.
11. The kit of claim 8 , comprising instructions for how to use the isoflavones or metabolites thereof to induce bone growth in a young or growing animal.
12. The kit of claim 11 , wherein the animal is gonadectomized.
13. The kit of claim 12 , wherein the animal is a puppy or kitten.
14. A dog or cat food comprising one or more isoflavones or metabolites thereof in an amount effective to induce bone growth in a young or growing dog or cat.
15. The dog or cat food of claim 14 , which is a puppy or kitten food.
16. The dog or cat food of claim 14 , further comprising one or more components selected from DT56a, androstenedione, dehydroepiandrosterone (DHEA), silicon, L-carnitine, conjugated linoleic acid, and orthosilicic acid.