Porous and nonporous materials for tissue grafting and repair
Implants having improved mechanical properties and/or degradation profiles, kits including such implants, and methods of producing and using the same.
1. A method for producing a thermally consolidated particle scaffold comprising:
coating a porous particle scaffold with a thermally stable material; and
heating the coated scaffold to a temperature above melt temperature of the particle scaffold and under melt temperature of the thermally stable material, to thermally consolidate the particles of the scaffold.
2. The method of claim 1 , wherein the porous particle scaffold comprises particles having at least two different shapes or sizes.
3. The method of claim 1 , wherein the particles comprise at least one polymer.
4. The method of claim 3 , wherein the particles comprise at least one polymer selected from the group consisting of poly(lactic acid); poly(glycolic acid) and poly(lactide-co glycolide).
5. The method of claim 1 , wherein the particle scaffold comprises two or more polymers having at least two different degradation profiles.
6. The method of claim 1 , wherein the particle scaffold comprises an elastomeric material.
7. The method of claim 1 , wherein the particle scaffold comprises at least one biologically active agent.
8. The method of claim 7 , wherein said at least one biologically active agent is selected from the group consisting of growth factors, antibiotic substances, cells, blood factors, and demineralized bone matrix powder.
9. The method of claim 1 , wherein said particle scaffold comprises a shape selected from the group consisting of a granule, a sheet, a rod, and a block.
10. The method of claim 1 , further comprising adapting said scaffold such that it may be used as at least one device selected from the group consisting of an interbody spacer, a fusion device, a bone graft, fusion cages, hone graft struts, structural augments, rods, screws, tacks, suture anchors, interference screws, a cartilage repair device, a tissue augmentation device, and a disc repair device.
11. The method of claim 1 , wherein the thermally stable material comprises at least one ingredient selected from the group consisting of resorbable polymers, resorbable copolymers, resorbable polymer blends, and resorbable ceramics.
12. The method of claim 1 , wherein said coating comprises at least partially coating the surface of the porous particle scaffold with the thermally stable material while essentially retaining the scaffold's porosity.
13. The method of claim 1 , wherein said coating comprises at least partially filling in the porosity of the porous particle scaffold with the thermally stable material.
14. The method of claim 1 , further comprising removing said thermally stable material after heating.
15. The method of claim 1 , wherein the thermally stable material remains on the particle scaffold after heating.
16. The method of claim 1 , further comprising adding the three-dimensional particle scaffold to an implant.
17. The method of claim 16 , wherein the implant is selected from the group consisting of an intervertebral spacer, rod, fracture screw, suture anchor, plate, and interference screw.
18. A method of treating a patient comprising inserting into a patient an implant comprising the thermally consolidated particle scaffold produced by the method of claim 1 .
19. A device comprising at least one thermally consolidated particle scaffold made by a method comprising:
coating a porous particle scaffold with a thermally stable material; and
heating the coated scaffold to a temperature above melt temperature of the particle scaffold and under melt temperature of the thermally stable material, to thermally consolidate the particles of the particle scaffold.