Methods of preventing ischemia/reperfusion damage to kidney using antibodies that bind BMP-1 isoforms
Uses of BMP-1 isoforms for diagnosing and treating defects and disorders of bone and soft tissues are described. Also described is a newly isolated variant of the BMP-1 isoform BMP-1-3.
1. A prophylactic method of treating acute ischemia/reperfusion damage to a kidney in an individual comprising: administering to the individual prior to a kidney ischemia/reperfusion event one or more antibody molecules specific for BMP-1-1 or BMP-1-3 in an amount effective to inhibit ischemia/reperfusion injury in said individual.
2. The method according to claim 1 , wherein the one or more antibody molecules is administered systemically to the individual prior to an ischemia/reperfusion event.
3. The method according to claim 1 , wherein an antibody molecule to BMP-1-1, an antibody molecule to BMP-1-3, or a combination of such antibody molecules is administered to the individual.