MCPIP as wound therapy
Disclosed herein are methods and compositions of treating a subject suffering from a wound. In exemplary examples, the method involves elevating MCPIP levels in a subject in need. Elevating MCPIP levels may involve direct administration (e.g. delivery of protein) or indirect administration (e.g. delivery vehicle capable of increasing expression of MCPIP).
1. A topical composition for application to a wound in a subject to promote healing of the wound, the wound composition comprising:
an effective amount of MCPIP polypeptide for treatment of the wound; and
a pharmaceutically acceptable carrier in a form configured for topical administration to the subject.
2. The topical composition of claim 1 , which is in a form selected from the group consisting of a solution, a suspension, a spray, a cream, a gel, a foam, an ointment, a lotion, and a powder.
3. The topical composition of claim 1 , wherein the pharmaceutically acceptable carrier comprises a dressing, the dressing selected from the group consisting of a transdermal patch, a pad, a powder, a matrix, and a bandage.
4. A kit comprising:
a pharmaceutical composition comprising an effective amount of MCPIP for treating a wound and a pharmaceutically acceptable carrier; and
instructions directing a user to use of the pharmaceutical composition in the treatment of a wound in a subject.
5. The kit of claim 4 , wherein the wound is at least one of a wound selected from the group consisting of an incomplete healing wound, a chronic wound, a burn, and a wound caused by trauma.
6. The kit of claim 4 , wherein the pharmaceutical composition is in a form from the group consisting of a solution, a suspension, a spray, a cream, a gel, a foam, an ointment, a lotion, or a powder.
7. The kit of claim 4 , wherein the pharmaceutically acceptable carrier comprises a dressing, the dressing selected from the group consisting of a transdermal patch, a pad, a powder, a matrix, and a bandage.