Combination for the treatment of osteoarthritis
The present invention relates to the use of a combination of glycine, proline, and optionally a natural or synthetic viscosity-controlling polymer, and/or lysine and/or leucine, to prepare a composition for the treatment of osteoarthritis.
1. A method of treating osteoarthritis in patients in need thereof, said method comprising
administering to said patients an effective amount of an intra-articular formulation consisting of:
a) glycine,
b) proline,
c) a natural or synthetic viscosity-controlling polymer;
d) lysine,
e) leucine; and
f) suitable excipients; and
treating said osteoarthritis in said patients.
2. The method as claimed in claim 1 , wherein osteoarthritis is patellofemoral or femorotibial knee osteoarthritis, hip osteoarthritis and shoulder osteoarthritis.
3. The method as claimed in claim 1 , wherein the natural or synthetic viscosity-controlling polymer is selected from hyaluronic acid or a salt thereof, polyvinylpyrrolidone and cellulose derivatives.
4. The method as claimed in claim 3 , wherein the natural or synthetic viscosity-controlling polymer is hyaluronic acid or a salt thereof.
5. The method as claimed in claim 1 , wherein the amino acids are in L form.
6. The method as claimed in claim 1 , wherein said formulation is in the form of powders for reconstitution or viscous solutions in biocompatible solvents.
7. A method of treating osteoarthritis in patients in need thereof, said method comprising
administering to said patients an effective amount of an intra-articular formulation consisting of
the following ranges by weight:
a) 25 to 500 mg of glycine,
b) 40 to 300 mg of proline,
c) 5 to 50 mg of hyaluronic acid or a salt thereof,
d) 5 to 100 mg of lysine,
e) 5 to 50 mg of leucine; and
f) suitable excipients.