Wound care products with peracid compositions
Methods have been developed for incorporation of a peracid compound into or on wound application matrices, such as bandages or dressings, and other matrices which will favorably impact wound healing and help eliminate microbial infection. The peracid compound comprises a base compound that is metabolically pertinent to wound healing, the oxidized form of the base compound (a peracid), and an appropriate oxidizer, such as hydrogen peroxide. In addition, other excipients with wound healing potential, such as esters of the base compound, may be added to the peracid compound. The combination peracid-wound application matrices can be used to disinfect and heal various wound types with designed time release of the peracid compound.
1. A wound treating matrix comprising at least one layer which is non-aqueous that comprises an antimicrobial composition comprising a carboxylic acid, the peracid of said carboxylic acid, the ester of said carboxylic acid, and an oxidizer in a non-aqueous medium.
2. The wound treating matrix according to claim 1 , wherein the non-aqueous layer is biodegradable.
3. The wound treating matrix according to claim 1 , wherein the non-aqueous layer is dissolvable.
4. The wound treating matrix according to claim 1 , further comprises:
an aqueous layer;
wherein the aqueous layer is separated from the non-aqueous layer prior to use;
wherein in use, the non-aqueous layer is exposed to the aqueous layer, and the antimicrobial composition migrates into the aqueous layer.
5. The wound treating matrix according to claim 4 , further comprising a removable fluid-resistant barrier layer for initially separating the non-aqueous layer from the aqueous layer, wherein in use, the barrier is removed to allow contact between the non-aqueous layer and the aqueous layer.
6. The wound treating matrix according to claim 1 , wherein the antimicrobial composition is released from the non-aqueous layer when contacted with a water based fluid.
7. The wound treating matrix according to claim 6 , wherein the water based fluid is wound exudate.
8. The wound treating matrix according to claim 1 , wherein the non-aqueous layer provides a controlled release of the antimicrobial composition when contacted with a water based fluid.
9. The wound treating matrix according to claim 4 , wherein the aqueous layer provides a controlled delivery of the antimicrobial composition when contacted with a water based fluid or exudate.
10. The wound treating matrix according to claim 4 , wherein the aqueous layer is a hydrogel.
11. The wound treating matrix according to claim 1 , further comprising a surfactant.
12. The wound treating matrix according to claim 1 , further comprising a stabilizing agent.
13. The wound treating matrix according to claim 1 , further comprising an emulsifying agent.
14. The wound treating matrix according to claim 1 , wherein the peracid is a peroxy α-ketocarboxylic acid.
15. The wound treating matrix according to claim 14 , wherein the peroxy α-ketocarboxylic acid is selected from peroxy α-ketopyruvic acid, peroxy α-ketobutyric acid, peroxy α-ketovaleric acid, or a mixture of thereof.
16. The wound treating matrix according to claim 1 , further comprising a liquid-impermeable backing layer adjacent to the non-aqueous layer.
17. The wound treating matrix according to claim 16 , wherein the backing layer is adhesive-coated and provides an adhesive-coated margin around the non-aqueous layer.
18. The wound treating matrix according to claim 1 , wherein the non-aqueous layer further comprises a polymer and the peracid is chemically bonded to the polymer.
19. A method for treating a wound, comprising providing the wound treating matrix according to claim 1 , and topically applying the wound treating matrix to the wound.
20. A wound treating matrix according to claim 1 further comprising at least one layer comprising a wound treating agent.
21. The wound treating matrix according to claim 20 , wherein the wound treating agent is one or more of (1) hemostatic agent, (2) anti-inflammatory drug, (3) analgesic drug, (4) angiogenesis promoters.
22. A wound treating matrix comprising a wound treating agent and a peracid composition according to claim 1 , wherein the peracid composition is encapsulated in a biocompatible structure.
23. The wound treating matrix of according to claim 22 , wherein the biocompatible structure is a nanostructure, liposome, or micelle.
24. A wound treating matrix according to claim 1 further comprising a polymer and wherein the peracid is chemically bonded to the polymer.
25. The wound treating matrix according to claim 24 , wherein the polymer is polyvinyl.
26. The wound treating matrix according to claim 24 , wherein the polymer is polyurethane.
27. The wound treating matrix according to claim 24 , wherein the polymer is a resin or protein.