Sericin extracted fabrics
Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.
1. A method for facilitating tissue generation comprising the step of implanting a biodegradable silk fabric into the individual, wherein:
(a) the biodegradable silk fabric is comprised of one or more individual yarns comprised of silkworm derived, sericin-extracted silk fibroin fibers, and;
(b) the silk fibroin fibers have not been dissolved and reconstituted.
2. The method of claim 1 , wherein the fabric is implanted intramuscularly.
3. The method of claim 1 , wherein the fabric is implanted into an individual to replace or repair damaged tissue.
4. The method of claim 1 , wherein the fabric is implanted subcutaneously.
5. The method of claim 1 , wherein the fabric has one or more biomechanical properties of a connective tissue.
6. A method for facilitating tissue generation comprising the step of subcutaneously implanting in an individual a biodegradable silk fabric that has one or more biomechanical properties of a connective tissue into the individual, wherein:
(a) the biodegradable silk fabric is comprised of one or more individual yarns comprised of silkworm derived, sericin extracted silk fibroin fibers, and;
(b) the silk fibroin fibers have not been dissolved and reconstituted, and wherein the fabric is implanted into the individual to replace or repair damaged tissue.