IP Library › Granted Patent US 9,416,106
Granted Patent B2
US 9,416,106 · App. 14/840,801 · Granted Aug 16, 2016

2-aminopyridine-based selective neuronal nitric oxide synthase inhibitors

Inventors: Richard B. Silverman (Winnetka, IL); Qing Jing (Morton Grove, IL)
Assignee: Northwestern University
C07D213/73C07D401/12C07D401/14
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Quick Facts
Patent No.
US 9,416,106
App. No.
14/840,801
Granted
Aug 16, 2016
Kind
B2
Abstract

Aminopyridine compounds, as can be used in conjunction with methods for modulation of nitric oxide synthase activity.

Claims (7)

1. A compound selected from compounds of a formula

wherein R 1 is selected from 6-aminopyridin-2-yl and 6-amino-4-methylpyridin-2-yl moieties; X is selected from CH 2 O, CH 2 CH 2 and CH 2 OCH 2 moieties; Y is selected from O and CH 2 moieties; and n is an integer selected from 1 and 2, and salts thereof.

2. The compound of claim 1 wherein R 1 is a 6-amino-4-methylpyridin-2-yl moiety.

3. The compound of claim 2 wherein X is selected from CH 2 O and CH 2 OCH 2 moieties.

4. The compound of claim 2 wherein n is 1.

5. The compound of claim 1 wherein said compound is an ammonium salt.

6. The compound of claim 4 wherein said ammonium salt has a counter ion that is a conjugate base of a protic acid.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 15, 2015
From: SILVERMAN, RICHARD B.; JING, QING
To: NORTHWESTERN UNIVERSITY
Reel/Frame 036800/0368 →
Continuity (3)
Division 14199599 · Mar 6, 2014
Provisional Application 61774147 · Mar 7, 2013
Related Publication 20150368201A1 · Dec 24, 2015