Compositions for treating biofilms and methods for using same
Compositions containing a surface active agent and a sub-lethal amount of an antimicrobial agent and methods for using such compositions are provided herein.
1. A dressing for treating or preventing a microbial biofilm comprising:
a composition layer comprising about 30 w/w % to about 80 w/w % surface active agent selected from the group consisting of poloxamer 127, poloxamer 188, poloxamer 237, poloxamer 335, poloxamer 407, and combinations thereof and about 1% or less by weight of the composition of an antimicrobial agent; and
a dressing material supporting the composition layer.
2. The dressing of claim 1 , wherein the antimicrobial agent is selected from the group consisting of an antibacterial, an antifungal, an antiviral, and combinations thereof.
3. The dressing of claim 1 , wherein the antimicrobial agent is selected from the group consisting of furaltadone, furazolium chloride, nifuradene, nifuratel, nifurfoline, nifurpirinol, nifurprazine, nifurtoinol, nitrofurantoin, furazolidone, 2-(methoxymethyl)-5-nitrofuran, nidroxyzone, nifuroxime, nifurazide, nitrofurazone, nystatin, polymyxin, silver sulfadiazine, nanocrystalline silver, ionic silver, silver salts, iodine, benzalkonium chloride, alcohol, hydrogen peroxide, chlorhexidine, honey, and combinations thereof.
4. The dressing of claim 1 , wherein the antimicrobial agent is silver sulfadiazine.
5. The dressing of claim 1 , wherein the surface active agent is poloxamer 188.
6. The dressing of claim 1 , wherein the composition layer impregnates the dressing material.
7. A method for treating a wound comprising:
applying a dressing to the wound, the dressing comprising:
a composition layer comprising about 30 w/w % to about 80 w/w % surface active agent selected from the group consisting of poloxamer 127, poloxamer 188, poloxamer 237, poloxamer 335, poloxamer 407, and combinations thereof and about 1% or less by weight of the composition of an antimicrobial agent; and
a dressing material supporting the composition layer.
8. The method of claim 7 , wherein the antimicrobial agent is selected from the group consisting of an antibacterial, an antifungal, an antiviral or a combination thereof.
9. The method of claim 7 , wherein the antimicrobial agent is selected from the group consisting of furaltadone, furazolium chloride, nifuradene, nifuratel, nifurfoline, nifurpirinol, nifurprazine, nifurtoinol, nitrofurantoin, furazolidone, 2-(methoxymethyl)-5-nitrofuran, nidroxyzone, nifuroxime, nifurazide, nitrofurazone, nystatin, polymyxin, silver sulfadiazine, nanocrystalline silver, ionic silver, silver salts, iodine, benzalkonium chloride, alcohol, hydrogen peroxide, chlorhexidine, honey and combinations thereof.
10. The method of claim 7 , wherein the antimicrobial agent is silver sulfadiazine.
11. The method of claim 7 , wherein the surface active agent is poloxamer 188.
12. The method of claim 7 , wherein the composition layer impregnates the dressing material.
13. A method for treating a wound comprising:
contacting the wound with a dressing comprising:
a composition layer comprising about 30 w/w % to about 80 w/w % surface active agent selected from the group consisting of poloxamer 127, poloxamer 188, poloxamer 237, poloxamer 335, poloxamer 407, and combinations thereof and about 1% or less by weight of the composition of an antimicrobial agent; and
a dressing material supporting the composition layer.
14. The method of claim 13 , wherein the antimicrobial agent is selected from the group consisting of an antibacterial, an antifungal, an antiviral, and combinations thereof.
15. The method of claim 13 , wherein the antimicrobial agent is selected from the group consisting of furaltadone, furazolium chloride, nifuradene, nifuratel, nifurfoline, nifurpirinol, nifurprazine, nifurtoinol, nitrofurantoin, furazolidone, 2-(methoxymethyl)-5-nitrofuran, nidroxyzone, nifuroxime, nifurazide, nitrofurazone, nystatin, polymyxin, silver sulfadiazine, nanocrystalline silver, ionic silver, silver salts, iodine, benzalkonium chloride, alcohol, hydrogen peroxide, chlorhexidine, honey, and combinations thereof.
16. The method of claim 13 , wherein the antimicrobial agent is silver sulfadiazine.
17. The method of claim 13 , wherein the surface active agent is poloxamer 188.
18. The dressing of claim 13 , wherein the composition layer impregnates the dressing material.