IP Library › Granted Patent US 9,765,055
Granted Patent B2
US 9,765,055 · App. 14/589,690 · Granted Sep 19, 2017

Intramolecular hydrogen-bonded nitric oxide synthase inhibitors

Inventors: Richard B. Silverman (Winnetka, IL); Fengtian Xue (Baton Rouge, LA)
Assignee: Northwestern University
C07D401/06C07D405/14C12N9/99
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Quick Facts
Patent No.
US 9,765,055
App. No.
14/589,690
Granted
Sep 19, 2017
Kind
B2
Abstract

Compounds and related compositions and methods as can be used to selectively inhibit neuronal nitric oxide synthase and as can be employed in the treatment of various neurodegenerative diseases.

Claims (5)

1. A compound selected from compounds of a formula

wherein Y is a covalent bond; Φ is a furanyl moiety; and X is an unshared electron pair on a heteroatom of said furanyl moiety, and salts thereof.

2. The compound of claim 1 comprising a cis diastereomeric configuration.

3. The compound of claim 1 wherein said compound is an ammonium salt.

4. The compound of claim 1 wherein said compound is an ammonium salt, and said salt has a counter ion that is a conjugate base of a protic acid.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 7, 2015
From: SILVERMAN, RICHARD B.; XUE, FENGTIAN
To: NORTHWESTERN UNIVERSITY
Reel/Frame 035347/0317 →
Continuity (3)
Division 13250554 · Sep 30, 2011
Provisional Application 61388375 · Sep 30, 2010
Related Publication 20150252020A1 · Sep 10, 2015