Methods of treating myeloma and lymphoma using compositions containing an ion pair of a lipoic acid derivative
The invention provides a method of treating myeloma and lymphoma using a pharmaceutical composition containing a pharmaceutically acceptable diluent along with an ion pair formed by triethanolamine and a compound of Formula I:
1. A method of treating a disease selected from the group consisting of myeloma and lymphoma, comprising administering to a patient in need thereof to treat the disease a therapeutically effective amount of a pharmaceutical formulation comprising:
(a) a compound of Formula I:
(b) triethanolamine; and
(c) a pharmaceutically acceptable diluent;
wherein the compound of Formula I and triethanolamine form an ion pair.
2. The method of claim 1 , wherein the disease is myeloma.
3. The method of claim 1 , wherein the disease is lymphoma.
4. The method of claim 1 , wherein the compound of Formula I and triethanolamine are present in a molar ratio ranging from about 20:1 to about 1:20.
5. The method of claim 2 , wherein the compound of Formula I and triethanolamine are present in a molar ratio ranging from about 20:1 to about 1:20.
6. The method of claim 3 , wherein the compound of Formula I and triethanolamine are present in a molar ratio ranging from about 20:1 to about 1:20.
7. The method of claim 1 , wherein the diluent is selected from the group consisting of saline, a sugar solution, an alcohol, dimethylformamide, dimethylsulfoxide, dimethylacetamide, and combinations thereof.
8. The method of claim 2 , wherein the diluent is selected from the group consisting of saline, a sugar solution, an alcohol, dimethylformamide, dimethylsulfoxide, dimethylacetamide, and combinations thereof.
9. The method of claim 3 , wherein the diluent is selected from the group consisting of saline, a sugar solution, an alcohol, dimethylformamide, dimethylsulfoxide, dimethylacetamide, and combinations thereof.
10. The method of claim 4 , wherein the diluent is selected from the group consisting of saline, a sugar solution, an alcohol, dimethylformamide, dimethylsulfoxide, dimethylacetamide, and combinations thereof.
11. The method of claim 5 , wherein the diluent is selected from the group consisting of saline, a sugar solution, an alcohol, dimethylformamide, dimethylsulfoxide, dimethylacetamide, and combinations thereof.
12. The method of claim 6 , wherein the diluent is selected from the group consisting of saline, a sugar solution, an alcohol, dimethylformamide, dimethylsulfoxide, dimethylacetamide, and combinations thereof.
13. The method of claim 1 , wherein the diluent is a dextrose solution.
14. The method of claim 2 , wherein the diluent is a dextrose solution.
15. The method of claim 3 , wherein the diluent is a dextrose solution.
16. The method of claim 4 , wherein the diluent is a dextrose solution.
17. The method of claim 5 , wherein the diluent is a dextrose solution.
18. The method of claim 6 , wherein the diluent is a dextrose solution.
19. The method of claim 17 , wherein the dextrose solution contains an amount of dextrose ranging from about 2.5% to about 10% by weight.
20. The method of claim 18 , wherein the dextrose solution contains an amount of dextrose ranging from about 2.5% to about 10% by weight.