Bodipy dyes for biological imaging
This invention relates to water-soluble mono-alkoxy and mono-alkyne BODIPY derivatives, including methods for making the same. For examples, provided herein are compounds of Formula (I): (I) or a pharmaceutically acceptable salt thereof, wherein: (a) is a BODIPY ligand system; X is a halogen; L is absent or a linker; and Z is selected from the group consisting of: a group reactive with a biologically active molecule and a detectable agent.
1. A compound of Formula (I):
wherein:
is a BODIPY ligand system;
X is 18 F or 19 F;
L is absent or a linker; and
Z is selected from the group consisting of: a group reactive with a biologically active molecule and a detectable agent;
wherein the moiety O-L-Z is selected from the group consisting of:
wherein n and m are independently an integer from 1 to 20; and
p is an integer from 0 to 20.
2. A compound of Formula (II):
wherein:
is a BODIPY ligand system;
X is 18 F or 19 F;
L is absent or a linker; and
Z is selected from the group consisting of: a group reactive with a biologically active molecule and a detectable agent;
wherein the moiety (C 2 )-L-Z is selected from the group consisting of:
wherein n and m are each independently an integer from 1 to 20, and p is an integer from 0 to 20.
3. The compound of claim 1 , wherein X is 18 F.
4. A compound selected from the group consisting of:
wherein the F bound to B is 18 F or 19 F.
5. A compound selected from the group consisting of:
wherein the F bound to B is 18 F or 19 F.
6. A compound of Formula (III):
wherein:
is a BODIPY ligand system selected from the group consisting of:
X is 18 F or 19 F; and
R 1 is selected from the group consisting of: a substituted or unsubstituted C 1-20 alkyl, substituted or unsubstituted C 1-20 alkoxy, or substituted or unsubstituted C 1-20 alkynyl.
7. A compound of Formula (VII):
wherein:
is a BODIPY ligand system; and
each L-Z is
8. The compound of claim 7 , wherein the compound of Formula (VII) is selected from the group consisting of: