Methods of treating pancreatic and ovarian cancers using compositions containing an ion pair of a lipoic acid derivative
Pharmaceutical formulations containing lipoic acid derivatives and ion pairs thereof are described. The pharmaceutical formulations are useful in the treatment of medical disorders, such as cancer.
1. A method of treating a cancer of the pancreas or ovary in a patient, comprising administering to a patient in need thereof a pharmaceutical formulation comprising:
(a) a compound of Formula I:
(b) triethanolamine; and
(c) a pharmaceutically acceptable diluent;
wherein the compound of Formula I and triethanolamine form an ion pair.
2. The method of claim 1 , wherein the triethanolamine and the compound of Formula I is present in a ratio ranging from 20:1 to 1:20.
3. The method of claim 1 , wherein the ion pair is present in the pharmaceutical formulation in an amount to provide from 0.001 mg/m 2 to 10 g/m 2 of the compound of Formula I upon administration of the pharmaceutical formulation to the patient.
4. The method of claim 1 , wherein the diluent is selected from the group consisting of saline, a sugar solution, an alcohol, dimethylformamide, dimethylsulfoxide, dimethylacetamide, and combinations thereof.
5. The method of claim 1 , wherein the diluent is a dextrose solution.
6. The method of claim 5 , wherein the dextrose solution contains an amount of dextrose ranging from 2.5% to 10% by weight.
7. The method of claim 1 , wherein the cancer is a cancer of the pancreas.
8. The method of claim 2 , wherein the cancer is a cancer of the pancreas.
9. The method of claim 5 , wherein the cancer is a cancer of the pancreas.
10. The method of claim 1 , wherein the cancer is a cancer of the ovary.
11. The method of claim 2 , wherein the cancer is a cancer of the ovary.
12. The method of claim 5 , wherein the cancer is a cancer of the ovary.