Granted Patent
B2
US 9,624,305 · App. 15/054,891 · Granted Apr 18, 2017
Methods of manipulating phagocytosis mediated by CD47
Inventors:
Siddhartha Jaiswal (San Francisco, CA); Irving L. Weissman (Stanford, CA); Ravindra Majeti (Palo Alto, CA); Mark P. Chao (Mountain View, CA)
C07K16/3061A61K39/39558A61K47/4863A61K47/48569A61K47/48607A61K47/48615A61K47/48623A61K47/48638C07K16/18C07K16/2803C07K16/2896C07K16/30C07K16/3038C07K16/3046C07K16/3053C07K16/3069A61K2039/505A61K2039/507C07K2317/31C07K2317/76
View Patent ↗
Loading inventors, assignments & file history…
Abstract
Methods are provided to manipulate phagocytosis of cancer cells, including e.g. leukemias, solid tumors including carcinomas, etc.
Claims (4)
1. A method of treating a human subject for melanoma, the method comprising:
administering to a human subject in need thereof an antibody that disrupts the binding of CD47 with SIRPα, at a dose that achieves a depletion in melanoma cancer cells by increasing phagocytosis of cancer cells.
2. The method of claim 1 , wherein the antibody that disrupts the binding of CD47 with SIRPα specifically binds to CD47.
3. The method of claim 1 , wherein the antibody is a humanized or chimeric monoclonal antibody.
Assignments (2)
CONFIRMATORY LICENSE
Recorded Jul 11, 2016
From: STANFORD UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 039298/0776 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Mar 31, 2016
From: JAISWAL, SIDDHARTHA; WEISSMAN, IRVING L.; MAJETI, RAVINDRA; CHAO, MARK P.
To: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Reel/Frame 038162/0162 →
Continuity (7)
Continuation In Part
PCTUS2009000319
· Jan 15, 2009
Provisional Application
61011324
· Jan 15, 2008
Provisional Application
61189786
· Aug 22, 2008