Compounds, compositions and methods useful for cholesterol mobilization
The invention relates to classes of pharmaceutically-active heterocyclic compounds and pharmaceutically acceptable salts, and hydrates thereof, and compositions comprising the same. The invention also relates to methods for treating or preventing a disease or disorder, which comprises administering a therapeutically or prophylactically effective amount a compound described herein.
1. A method for treating a hepatic steatosis, comprising administering to a subject in need thereof an effective amount of a compound of Formula (II):
or a pharmaceutically acceptable salt thereof, wherein
each R 9 is independently —H, -hydrocarbyl, -aryl, -aralkyl, -heteroaryl, -heterocyclyl, —C(O)O(alkyl), —OC(O)(alkyl), —C(O)NH 2 , —C(O)NH(alkyl), —C(O)N(alkyl)(alkyl), —NHC(O)(alkyl), N(alkyl)C(O)(alkyl), or —SO 2 NH 2 ;
each R 10 is independently —H, —OH, —NH 2 , —NH(alkyl), —N(alkyl)(alkyl), hydrocarbyl, —O-alkyl, —O-alkenyl, aryl, —O-aryl, aralkyl, —O-aralkyl, heteroaryl, —O-heteroaryl, heterocyclyl,
—O-heterocyclyl, halo, —OCF 3 , —C(O)O(alkyl), —OC(O)(alkyl), —C(O)NH 2 , —C(O)NH(alkyl), —C(O)N(alkyl)(alkyl), —NHC(O)(C 2 -C 10 -alkyl), —N(alkyl)C(O)(alkyl), —OC(O)O(alkyl), —OC(O)NH 2 , —OC(O)NH(alkyl), —OC(O)N(alkyl)(alkyl), —CHNH, —CHN(alkyl), or —SO 2 NH 2 ;
each of Q 1 , Q 2 , and Q 3 is independently CR 10 or N;
X is CHR 10 , S, O, or NR 9 ; and
each m is independently an integer from 0-3.
2. The method of claim 1 , wherein the compound has the structure:
or a pharmaceutically acceptable salt of any of the foregoing.
3. The method of claim 1 , wherein R 9 is H and R 10 is OH.
4. The method of claim 3 , wherein each m is 1.
5. The method of claim 1 , wherein the compound has the structure:
6. The method of claim 1 , wherein the hepatic steatosis is alcoholic hepatic steatosis or non-alcoholic hepatic steatosis.
7. The method of claim 1 , wherein the compound or pharmaceutically acceptable salt thereof is present in a composition that further comprises a pharmaceutically acceptable vehicle or carrier.
8. The method of claim 7 , wherein the composition is formulated for oral administration.
9. The method of claim 7 , wherein the composition is in the form of a tablet or capsule.
10. The method of claim 7 , wherein the compound or pharmaceutically acceptable salt thereof is present in the composition in an amount of about 1 mg to about 1,000 mg.
11. A method for treating a hepatic steatosis, comprising administering to a subject in need thereof an effective amount of a compound having the structure:
or a pharmaceutically acceptable salt of any of the foregoing.
12. The method of claim 11 , wherein the hepatic steatosis is alcoholic hepatic steatosis or non-alcoholic hepatic steatosis.
13. The method of claim 11 , wherein the compound or pharmaceutically acceptable salt thereof is a present in a composition that further comprises a pharmaceutically acceptable vehicle or carrier.
14. The method of claim 13 , wherein the composition is formulated for oral administration.
15. The method of claim 13 , wherein the composition is in the form of a tablet or capsule.
16. The method of claim 13 , wherein the compound or pharmaceutically acceptable salt thereof is present in the composition in an amount of about 1 mg to about 1,000 mg.