Connective-tissue-based or dermal-tissue-based grafts/implants
The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic gent to attract a desired cell.
1. A dermal scaffold implant comprising
a matrix of allogeneic or xenogenic tissue wherein said matrix is formed from a processed dermal tissue slurry and said matrix is dried to a shape selected from the group consisting of a disk, a strip, a sheet, a molded 3D shaped object, a sponge, and a gasket; and
wherein said implant has the property of holding said shape during rehydration and handling.
2. The implant of claim 1 wherein said shape is a molded 3D shape to fit an anatomical feature or surgically created space.
3. The implant of claim 1 , wherein the implant further comprises seeded cells, a growth factor, a chemotactic agent, or a combination thereof.
4. The implant of claim 3 , wherein the implant comprises a growth factor for inducing the growth of fibroblasts, melanocytes, osteogenic cells, stem cells, skin cells or a combination thereof.
5. The implant of claim 3 , wherein said implant comprises seeded cells that are fibroblasts, melanocytes, osteogenic cells, stem cells, skin cells or a combination thereof.
6. The implant of claim 1 , which has a moisture content of 3% or less.
7. The implant of claim 1 , wherein said shape is a strip.
8. The implant of claim 7 , wherein said strip has dimensions of about 10 mm to 500 mm long, by about 10 mm to 200 mm wide and about 1 mm to 10 mm thick.
9. The implant of claim 7 , wherein said strip has dimensions of about 50 mm to 90 mm long by about 15 mm to 35 mm wide and about 2 mm to 5 mm thick.
10. The implant of claim 7 , wherein said strip has a cross section of a rectangle, square, triangle, polygon, circle, half circle, ellipse, or partial ellipse.
11. The implant of claim 1 , wherein said shape is a disk.
12. The implant of claim 11 , wherein said disk has dimensions of about 10 mm to 100 mm diameter and about 1 mm to 10 mm thick.
13. The implant of claim 1 , wherein said shape is a molded 3D shape.
14. The implant of claim 13 , wherein said molded 3D shape has dimensions of about 100 mm by about 100 mm and about 25 mm thick.
15. The implant of claim 13 , wherein said molded 3D shape has dimensions of about 50 mm by about 70 mm and about 20 mm thick.
16. The implant of claim 13 , wherein said molded 3D shape has dimensions of about 30 mm by about 50 mm and about 15 mm thick.
17. The implant of claim 1 , wherein said shape is a sheet.
18. The implant of claim 13 , wherein said sheet has dimensions of about 100 mm by about 100 mm and about 25 mm thick.
19. The implant of claim 13 , wherein said sheet has dimensions of about 20 mm to 300 mm by about 10 mm to 100 mm and about 1 mm to 10 mm thick.
20. The implant of claim 1 , wherein said implant is packaged and sterilized.
21. The implant of claim 1 , wherein said implant is rehydrated prior to use by contacting with water, saline, blood, plasma, a buffered solution, or another liquid.