Antimicrobial compositions and method of use thereof
The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.
1. A method of treating a gram negative microbial infection, comprising:
administering to a subject in need thereof an effective amount of an antimicrobial peptide comprising:
the amino acid sequence of VGFPVAAVGFPV (SEQ ID NO: 3);
one of more targeting domains; and
an Fc region, wherein the Fc region is linked to the one or more targeting domains.
2. The method of claim 1 , wherein said antimicrobial peptide has a length of 12-20 amino acids.
3. The method of claim 1 , wherein the one or more targeting domains of said antimicrobial peptide comprises an epitope binding domain.
4. The method of claim 1 , wherein said antimicrobial peptide comprises at least one VGFPV motif at the N-terminal.
5. The method of claim 1 , wherein said antimicrobial peptide comprises at least one VGFPV motif at the C-terminal.
6. The method of claim 1 , wherein said antimicrobial peptide further comprises a second antimicrobial domain, wherein said second antimicrobial domain is different for said first antimicrobial domain.
7. The method of claim 1 , wherein said antimicrobial peptide further comprises a cell penetrating peptide (CPP) domain.
8. The method of claim 1 , wherein said antimicrobial peptide is administered in combination with another antimicrobial agent.
9. The method of claim 8 , wherein said another antimicrobial agent is another antimicrobial peptide.
10. The method of claim 8 , wherein said another antimicrobial agent is an in vivo expression vector encoding said antimicrobial peptide.
11. The method of claim 8 , wherein said antimicrobial peptide is a PEGylated peptide.