IP Library Granted Patent US 10,717,209
Granted Patent B2
US 10,717,209 · App. 15/605,746 · Granted Jul 21, 2020

Methods and materials for fabricating laminate nanomolds and nanoparticles therefrom

Inventors: Jason P. Rolland (Belmont, MA); Benjamin Maynor (Durham, NC); Robert Lyon Henn (Raleigh, NC)
Assignee: LIQUIDIA TECHNOLOGIES, INC.
B29C33/3857B29C33/3807B29C33/40B29C33/42B29C43/222B29C43/28B29C43/3697B32B3/30B32B37/182B32B38/0012B82Y10/00B82Y40/00G03F7/0002B29C2033/385B29K2067/003B29K2071/00B29K2667/003B29K2867/003B29K2871/00B29L2031/756Y10S425/81Y10T428/265Y10T428/3154
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Quick Facts
Patent No.
US 10,717,209
App. No.
15/605,746
Granted
Jul 21, 2020
Kind
B2
Abstract

A laminate nanomold includes a layer of perfluoropolyether defining a cavity that has a predetermined shape and a support layer coupled with the layer of perfluoropolyether. The laminate can also include a tie-layer coupling the layer of perfluoropolyether with the support layer. The tie-layer can also include a photocurable component and a thermal curable component. The cavity can have a broadest dimension of less than 500 nanometers.

Claims (30)

1. A system for making a laminate mold, comprising:

a patterned master defining structures configured to receive a curable material;

a support layer configured to mate with the patterned master and conform the curable material with the structures of the patterned master; and

a curing device configured to cure the curable material such that the curable material substantially retains a mirror image of the structures of the patterned master, wherein after removal of the patterned master the combined support layer and cured material have a modulus of at least 200 times the modulus of the cured curable material without the support layer.

2. The system of claim 1 , wherein the support layer comprises a roller configured to engage the curable material with the patterned master.

3. The system of claim 2 , wherein the patterned master and mated support layer engage the roller in conformal contact.

4. The system of claim 1 , wherein the cured curable material has a thickness less than 75 micrometers.

5. The system of claim 1 , wherein the structures have a width to height aspect ratio of less than 50:1.

6. The system of claim 1 , wherein the structures have a width to height aspect ratio of less than 20:1.

7. The system of claim 1 , wherein the curable material comprises a fluoropolymer.

8. The system of claim 1 , wherein the curable material comprises a poly(dimethylsiloxane).

9. The system of claim 1 , further comprising a composition configured to be deposited on the mirror image of the structures of the patterned master in the cured curable material to form particles.

10. A system for making a laminate mold, comprising:

a patterned master defining structures configured to receive a curable material;

a support layer configured to mate with the patterned master and conform the curable material with the structures of the patterned master; and

a curing device configured to cure the curable material such that the curable material substantially retains a mirror image of the structures of the patterned master, wherein after removal of the patterned master the combined support layer and cured material have a modulus of at least 1000 Mpa.

11. The system of claim 10 , wherein the support layer comprises a roller configured to engage the curable material with the patterned master.

12. The system of claim 11 , wherein the patterned master and mated support layer engage the roller in conformal contact.

13. The system of claim 10 , wherein the cured curable material has a thickness less than 75 micrometers.

14. The system of claim 10 , wherein the structures have a width to height aspect ratio of less than 50:1.

15. The system of claim 10 , wherein the curable material comprises a fluoropolymer.

16. The system of claim 10 , wherein the curable material comprises a poly(dimethylsiloxane).

17. The system of claim 10 , further comprising a composition configured to be deposited on the mirror image of the structures of the patterned master in the cured curable material to form particles.

18. A system for making a laminate mold, comprising:

a patterned master defining structures configured to receive a curable material;

a support layer configured to mate with the patterned master and conform the curable material with the structures of the patterned master;

a curing device configured to cure the curable material such that the curable material substantially retains a mirror image of the structures of the patterned master, wherein after removal of the patterned master the combined support layer and cured material have a modulus of at least 1000 Mpa; and

a composition configured to be deposited on the mirror image of the structures of the patterned master in the cured curable material to form particles.

19. The system of claim 18 , wherein the support layer comprises a roller configured to engage the curable material with the patterned master.

20. The system of claim 18 , wherein the curable material is selected from a fluoropolyether or a poly(dimethylsiloxane).

Assignments (3)
ASSIGNMENT OF IP SECURITY AGREEMENT RECORDED AT REEL/FRAME 062643/0791 Recorded May 11, 2023
From: HCR COLLATERAL MANAGEMENT, LLC, AS RETIRING SUBORDINATED LENDER
To: HEALTHCARE ROYALTY PARTNERS IV, L.P., AS SUCCESSOR SUBORDINATED LENDER
Reel/Frame 063627/0307 →
SECURITY INTEREST Recorded Feb 9, 2023
From: LIQUIDIA TECHNOLOGIES, INC.
To: HCR COLLATERAL MANAGEMENT, LLC
Reel/Frame 062643/0791 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 3, 2018
From: ROLLAND, JASON P.; MAYNOR, BENJAMIN; HENN, ROBERT L.
To: LIQUIDIA TECHNOLOGIES, INC.
Reel/Frame 044520/0868 →
Continuity (7)
Continuation 15138831 · Apr 26, 2016
Continuation 14574543 · Dec 18, 2014
Continuation 14157971 · Jan 17, 2014
Division 13834454 · Mar 15, 2013
Continuation 13354046 · Jan 19, 2012
Continuation 11633763 · Dec 4, 2006
Related Publication 20170259461A1 · Sep 14, 2017