Granted Patent B2

US 12,599,623 · App. 15/638,059 · Granted Apr 14, 2026

Inventors: Betty Yu (Cambridge, MA); Joseph Lomakin (Cambridge, MA); Soo-Young Kang (Newton, MA); Benjamin W. Adams (Seattle, WA)

Assignee: Shiseido Company, Limited

A61K31/765A61K8/0204A61K8/19A61K8/25A61K8/29A61K8/345A61K8/585A61K8/891A61K8/894A61K8/895A61L26/0019A61L26/0095A61Q1/02A61Q1/14A61Q19/00A61Q19/06A61Q19/08A61K2800/412A61K2800/43A61K2800/58A61K2800/5922A61K2800/884A61K2800/95

Abstract

Claims (26)

1 . A two-component formulation comprising:

a) a first component comprising

(i) at least one alkenyl functionalized organopolysiloxane and at least one hydride functionalized polysiloxane; and

(ii) fumed silica; and

b) a second component comprising a catalyst and water, wherein the content of water in the second component is 28.25% by weight or more and 90% by weight or less;

wherein the first component and the second component are packaged separately; and

wherein the at least one alkenyl functionalized organopolysiloxane is a polymer of formula IIa and the at least one hydride functionalized polysiloxane is a polymer of formula III:

wherein:

R 1a′ , R 3a′ , R 4a′ , R 5a′ , R 6a′ , R 8a′ , R 9a′ , and R 10a′ are each independently C 1-20 alkyl, C 2-20 alkenyl, C 5-10 aryl, hydroxyl, or C 1-20 alkoxyl;

p and q are each independently an integer from between 10 and 6000;

R 1b , R 2b , R 3b , R 6b , R 7b , and R 8b are each independently C 1-20 alkyl;

R 4b , R 5b , R 9b , and R 10b are each independently selected from the group consisting of hydrogen, C 1-20 alkyl, C 2-20 alkenyl, C 5-10 aryl, hydroxyl, and C 1-20 alkoxyl;

wherein at least two of R 4b , R 5b , R 9b , and R 10b are hydrogen; and

m and n are each independently an integer between 10 and 6000.

2 . The formulation of claim 1 , wherein the at least one alkenyl functionalized organopolysiloxane has an average molecular weight of between about 100,000 and about 200,000 Da.

3 . The formulation of claim 1 , wherein the at least one alkenyl functionalized organopolysiloxane has a weight percent of vinyl of between about 0.01 and about 0.3.

4 . The formulation of claim 1 , wherein the at least one alkenyl functionalized organopolysiloxane is selected from the group consisting of vinyl terminated polydimethylsiloxane; vinyl terminated diphenylsiloxane-dimethylsiloxane copolymers; vinyl terminated polyphenylmethylsiloxane, vinylphenylmethyl terminated vinylphenylsiloxane phenylmethylsiloxane copolymer; vinyl terminated trifluoropropylmethylsiloxane-dimethylsiloxane copolymer; vinyl terminated diethylsiloxane-dimethylsiloxane copolymer; vinylmethylsiloxane dimethylsiloxane copolymer, trimethylsiloxy terminated; vinylmethylsiloxane-dimethylsiloxane copolymers, silanol terminated; vinylmethylsiloxane-dimethylsiloxane copolymers, vinyl terminated; vinyl gums; vinylmethylsiloxane homopolymers; vinyl T-structure polymers; monovinyl terminated polydimethylsiloxanes; vinylmethylsiloxane terpolymers; vinylmethoxysilane homopolymers; and combinations thereof.

5 . The formulation of claim 1 , wherein the at least one hydride functionalized polysiloxane has an average molecular weight of between about 2000 and about 5000 Da.

6 . The formulation of claim 1 , wherein the at least one hydride functionalized polysiloxane has a viscosity of between about 5 and about 11,000 cSt at 25° C.

7 . The formulation of claim 1 , wherein the at least one hydride functionalized polysiloxane has a SiH content of between about 0.5 and about 10 mmol/g.

8 . The formulation of claim 1 , wherein the first component has a molar ratio of vinyl to hydride functional groups of about 1:40 to about 1:80.

9 . The formulation of claim 1 , wherein the second component further comprises a vinyl terminated organopolysiloxane.

10 . The formulation of claim 9 , wherein the vinyl terminated organopolysiloxane is less than about 50% by weight of the second component.

11 . The formulation of claim 1 , wherein the formulation further comprises one or more cosmetic or therapeutic agent.

12 . The formulation of claim 11 , wherein the one or more cosmetic or therapeutic agent is selected from a group consisting of anti-aging agents, anti-acne agents, anti-wrinkle agents, spot reducers, moisturizers, and vitamins.

13 . A method of forming a film on the skin of a subject, comprising applying the formulation of claim 1 to the skin of the subject.

Assignments (4)

Continuity (15)

References Cited (229)