Peptide/particle delivery systems
Polymeric nanoparticles, microparticles, and gels for delivering cargo, e.g., a therapeutic agent, such as a peptide, to a target, e.g., a cell, and their use for treating diseases, including angiogenesis-dependent diseases, such as age-related macular degeneration and cancer, are disclosed. Methods for formulating, stabilizing, and administering single peptides or combinations of peptides via polymeric particle and gel delivery systems also are disclosed.
1. A nanoparticle, microparticle, or gel comprising a compound of formula (I):
wherein:
n is an integer from 1 to 10,000;
R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 5 , and R 9 are each hydrogen;
R comprises a backbone of a diacrylate of formula BL2:
R′ comprises an alcohol, and R″ comprises an amine group;
and one or more nucleic acids selected from a gene, DNA, RNA, siRNA, miRNA, isRNA, agRNA, and smRNA.
2. The nanoparticle, microparticle, or gel of claim 1 , wherein n is an integer from 5 to 20.
3. The nanoparticle, microparticle, or gel of claim 1 , wherein R′ comprises a side chain derived from a compound selected from the group consisting of:
4. The nanoparticle, microparticle, or gel of claim 1 , wherein R″ comprises an end group derived from a compound selected from the group consisting of
5. The nanoparticle, microparticle, or gel of claim 1 further comprising poly(lactide-co-glycolide) (PLGA).
6. The nanoparticle, microparticle, or gel of claim 1 , wherein the nanoparticle, microparticle, or gel encapsulates the one or more nucleic acids.