Granted Patent
B2
US 12,527,746 · App. 17/149,583 · Granted Jan 20, 2026
Peptide/particle delivery systems
Inventors:
Jordan Jamieson Green (Nottingham, MD); Aleksander S. Popel (Lutherville, MD); Joel Chaim Sunshine (Pikesville, MD); Ron B. Shmueli (Baltimore, MD); Stephany Yi Tzeng (Baltimroe, MD); Kristen Lynn Kozielski (Baltimore, MD)
Assignee:
The Johns Hopkins University
A61K9/5026A61K9/0019A61K9/06A61K9/19A61K9/5146A61K31/7105A61K31/711A61K31/713A61K38/39A61K47/34B82Y5/00C12N15/111C12N15/88C12N2310/14C12N2320/32Y10T428/2982
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Abstract
Polymeric nanoparticles, microparticles, and gels for delivering cargo, e.g., a therapeutic agent, such as a peptide, to a target, e.g., a cell, and their use for treating diseases, including angiogenesis-dependent diseases, such as age-related macular degeneration and cancer, are disclosed. Methods for formulating, stabilizing, and administering single peptides or combinations of peptides via polymeric particle and gel delivery systems also are disclosed.
Claims (18)
1 . A nanoparticle, microparticle, or gel comprising a compound of formula (I):
wherein:
n is an integer from 1 to 10,000;
R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , and R 9 are each hydrogen
wherein R 1 is absent; and
wherein R′ comprises a side chain selected from the group consisting of:
wherein R″ comprises an end group selected from the group consisting of
wherein R comprises
and one or more nucleic acids.
2 . The nanoparticle, microparticle, or gel of claim 1 , wherein n is an integer selected from the group consisting of from 1 to 1,000, from 1 to 100, from 1 to 30, from 5 to 20, from 10 to 15, and from 1 to 10.
3 . The nanoparticle, microparticle, or gel of claim 1 , wherein the nucleic acid is selected from the group consisting of a gene, DNA, RNA, siRNA, miRNA, isRNA, agRNA, smRNA, and combinations thereof.
4 . The nanoparticle, microparticle, or gel of claim 3 , wherein the nucleic acid is an siRNA or a combination of siRNA.
5 . The nanoparticle, microparticle, or gel of claim 1 , wherein:
R comprises:
R′ comprises:
and
R″ comprises:
6 . The nanoparticle, microparticle, or gel of claim 1 , wherein the nucleic acid comprises siRNA.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 20, 2021
From: GREEN, JORDAN JAMIESON; POPEL, ALEKSANDER S.; SUNSHINE, JOEL CHAIM; SHMUELI, RON B.; TZENG, STEPHANY YI; KOZIELSKI, KRISTEN LYNN
To: THE JOHNS HOPKINS UNIVERSITY
Reel/Frame 054964/0020 →
Continuity (9)
Continuation
16860773
· Apr 28, 2020
Continuation In Part
PCTUS2010035127
· May 17, 2010
Provisional Application
61542995
· Oct 4, 2011
Provisional Application
61543046
· Oct 4, 2011
Provisional Application
61392224
· Oct 12, 2010
Provisional Application
61178611
· May 15, 2009
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