Aspirin derivatives and uses thereof
View Patent ↗The present invention provides novel aspirin derivatives useful for preventing and/or treating cancer. The novel compounds of this invention may be particularly useful for the prevention and/or treatment of cancers affecting the gastrointestinal system, such as colorectal cancer.
1. A method of treating colorectal cancer in a subject in need thereof, comprising:
administering to said subject a therapeutically effective amount of the following compound:
or a pharmaceutically acceptable salt thereof,
wherein:
R E is —O—C(O)—C 1-3 alkyl;
R F is
or
wherein n=3, 5, or 7; and
R G is —H or C 1-6 alkyl.
2. The method of claim 1 , wherein
R G is —H or -Me; and
R E is —O—C(O)-Me, —O—C(O)-Et, or —O—C(O)-Pr.
3. The method of claim 2 , wherein R E is —O—C(O)-Me and R G is -Me.
4. The method of claim 2 , wherein R F is
and n=3, 5, or 7.
5. The method of claim 2 , wherein R F is
and n=3, 5, or 7.
6. The method of claim 1 , wherein said compound has the structure
7. The method of claim 1 , wherein said compound has the structure
8. A method of treating lung cancer in a subject in need thereof, comprising:
administering to said subject a therapeutically effective amount of the following compound:
or a pharmaceutically acceptable salt thereof,
wherein:
R E is —O—C(O)—C 1-3 alkyl;
R F is
or
wherein n=3, 5, or 7; and
R G is —H or C 1-6 alkyl.
9. The method of claim 8 , wherein
R G is —H or -Me; and
R E is —O—C(O)-Me, —O—C(O)-Et, or —O—C(O)-Pr.
10. The method of claim 9 , wherein R E is —O—C(O)-Me and R G is -Me.
11. The method of claim 9 , wherein R F is
and n=3, 5, or 7.
12. The method of claim 9 , wherein R F is
and n=3, 5, or 7.
13. The method of claim 8 , wherein said compound has the structure
14. The method of claim 8 , wherein said compound has the structure