Acyclic nucleoside phosphonate diesters
The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer.
1. A method of treating cervical intraepithelial neoplasia, anal intraepithelial neoplasia, or vulvar intraepithelial neoplasia in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a compound of formula:
or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutically acceptable carrier.
2. The method of claim 1 , wherein the subject is a human.
3. The method of claim 1 , wherein the compound is topically administered as a topical formulation.
4. The method of claim 3 , wherein the topical formulation is a cream.
5. The method of claim 3 , wherein the topical formulation is a gel.
6. The method of claim 1 for treating cervical intraepithelial neoplasia.
7. The method of claim 6 , wherein the subject is a human.
8. The method of claim 6 , wherein the compound is topically administered as a topical formulation.
9. The method of claim 8 , wherein the topical formulation is a cream.
10. The method of claim 8 , wherein the topical formulation is a gel.
11. The method of claim 1 for treating anal intraepithelial neoplasia.
12. The method of claim 11 , wherein the subject is a human.
13. The method of claim 11 , wherein the compound is topically administered as a topical formulation.
14. The method of claim 13 , wherein the topical formulation is a cream.
15. The method of claim 13 , wherein the topical formulation is a gel.
16. The method of claim 1 for treating vulvar intraepithelial neoplasia.
17. The method of claim 16 , wherein the subject is a human.
18. The method of claim 16 , wherein the compound is topically administered as a topical formulation.
19. The method of claim 18 , wherein the topical formulation is a cream.
20. The method of claim 18 , wherein the topical formulation is a gel.
21. The method of claim 1 , wherein the cervical intraepithelial neoplasia, the anal intraepithelial neoplasia, or the vulvar intraepithelial neoplasia is caused by a human papilloma virus.