IP Library › Granted Patent US 10,624,370

Granted Patent B2

US 10,624,370 · App. 15/839,393 · Granted Apr 21, 2020

Compositions and methods that modulate digestibility in a companion animal

Inventors: Rondo P Middleton (Creve Coeur, MO); Brian M Zanghi (Ballwin, MO); Serge Andre Dominique Rezzi (Semsales, CH); Steven S Hannah (Chesterfield, MO)

Assignee: Societe des Produits Nestle S A

A23K50/40 A23K10/00 A23K10/20 A23K10/30 A23K20/00 A23K20/105 A23K20/111 A23K20/142 A23K20/147 A23K20/158 A23K20/163 A23K20/174 A23K50/42 A23K50/48

View Patent ↗

Loading inventors, assignments & file history…

Monitor This Case

Get email alerts when status or documents change.

Order Certified Copies

Most orders are placed with the USPTO same day — all within 24 business hours.

Order via The Patent Place →

Pre-filled with this patent's details

Quick Facts

Patent No.: US 10,624,370
App. No.: 15/839,393
Granted: Apr 21, 2020
Kind: B2

External Links

USPTO Patent Center↗ Full Patent PDF↗

Abstract

A specific type of digestibility in a companion animal can be improved by adjusting the diet of the animal to increase the amount of a compound which positively or negatively modulates the specific type of digestibility or adjusting the diet of the animal to decrease the amount of a compound which positively or negatively modulates the specific type of digestibility. The specific type of digestibility can be one or more of organic matter digestibility, dry matter digestibility, fiber digestibility, energy digestibility, fat digestibility, or protein digestibility.

Claims (36)

1. A method of modulating at least one of organic matter digestibility, dry matter digestibility, fiber digestibility, energy digestibility, fat digestibility or protein digestibility in a companion animal, comprising:

wherein the at least three distinct metabolites having trigonelline (N′-methylnicotinate) and mannose;

wherein the at least three distinct metabolites are present in the pet food composition in at least one amount selected from the group consisting of (i) about 0.01 wt. % to about 10 wt. % of the pet food composition and (ii) about 1 IU of the at least three metabolites/kg of the pet food composition to about 500,000 IU of the at least three metabolites/kg of the pet food composition;

wherein the metabolites that modulate organic matter digestibility are selected from the group consisting of trigonelline (N′-methylnicotinate), mannose, arachidonate (20:4n6), dihomo-linoleate (20:2n6), docosapentaenoate (n6 DPA; 22:5n6), pantothenate, X-09789, dihomo-linolenate (20:3n3), dihomo-linolenate (20:3n6), 3-hydroxybutyrate (BHBA), adrenate (22:4n6), docosapentaenoate (n3 DPA; 22:5n3), eicosenoate (20:1n9), eicosenoate (20:1n11), X-11378, alpha linolenate (18:3n3), gamma linolenate (18:3n6), stachydrine, glycerate, gamma-glutamylphenylalanine, X-16975, X-17185, arabitol, creatine, octanoylcamitine, trans-4-hydroxyproline, X-17010, glycolate (hydroxyacetate), N-acetylomithine, campesterol, oxidized glutathione (GSSG), phenylalanine, oleoyltaurine, arabonate, X-12450, palmitoleate (16:1n7), acetylcamitine, palmitate (16:0), erythritol, linoleate (18:2n6), stearate (18:0), and mixtures thereof;

wherein the metabolites that modulate dry matter digestibility are selected from the group consisting of mannose, trigonelline (N′-methylnicotinate), arachidonate (20:4n6), dihomo-linoleate (20:2n6), N-palmitoyl taurine, docosapentaenoate (n6 DPA; 22:5n6), X-09789, pantothenate, docosapentaenoate (n3 DPA; 22:5n3), X-16975, 3-hydroxybutyrate (BHBA), X-11378, linolenate [alpha or gamma; (18:3n3 or 6)], gamma-glutamylphenylalanine, dihomo-linolenate (20:3n3 or n6), eicosenoate (20:1n9 or 11), arabitol, adrenate (22:4n6), X-17185, Glycerate, glutathione (oxidized (GSSG)), mannitol, octanoylcamitine, N-acetylomithine, X-17010, glycolate (hydroxyacetate), stachydrine, campesterol, palmitoleate (16:1n7), creatine, X-12450, oleoyltaurine, arabonate, trans-4-hydroxyproline, phenylalanine, erythritol, palmitate (16:0), and mixtures thereof;

wherein the metabolites that modulate energy digestibility are selected from the group consisting of trigonelline (N′-methylnicotinate), mannose, arachidonate (20:4n6), dihomo-linoleate (20:2n6), docosapentaenoate (n6 DPA; 22:5n6), N-palmitoyl taurine, betaine, X-09789, pantothenate, adrenate (22:4n6), dihomo-linolenate (20:3n3), dihomo-linolenate (20:3n6), X-11378, glycerate, 3-hydroxybutyrate (BHBA), docosapentaenoate (n3 DPA; 22:5n3), stachydrine, X-17185, eicosenoate (20:1n9), eicosenoate (20:1n11), alpha linolenate (18:3n3), gamma linolenate (18:3n6), gamma-glutamylphenylalanine, X-16975, creatine, campesterol, glycolate (hydroxyacetate), X-17010, octanoylcamitine, N-acetylomithine, trans-4-hydroxyproline, phenylalanine, oxidized glutathione (GSSG), arabitol, mannitol, acetylcamitine, erythritol, oleoyltaurine, X-12450, palmitoleate (16:1n7), arabonate, palmitate (16:0), docosahexaenoate (DHA; 22:6n3), linoleate (18:2n6), stearate (18:0), and mixtures thereof;

wherein the metabolites that modulate fat digestibility are selected from the group consisting of trigonelline (N′-methylnicotinate), X-09789, arachidonate (20:4n6), mannose, betaine, oxidized glutathione (GSSG), X-11378, dihomo-linoleate (20:2n6), glycerate, campesterol, docosapentaenoate (n6 DPA; 22:5n6), glycolate (hydroxyacetate), pantothenate, adrenate (22:4n6), X-17185, N-acetylornithine, gamma-glutamylphenylalanine, octanoylcarnitine, stachydrine, dihomo-linolenate (20:3n3), dihomo-linolenate (20:3n6), docosapentaenoate (n3 DPA; 22:5n3), 3-hydroxybutyrate (BHBA), X-17010, X-16975, 15-methylpalmitate (isobar with 2-methylpalmitate), mannitol, citrulline, alpha linolenate (18:3n3), gamma linolenate (18:3n6), phenylalanine, erythritol, arabitol, eicosenoate (20:1n9), eicosenoate (20:1n11), cholate, gamma-glutamylalanine, creatine, 3-dehydrocholate, docosahexaenoate (DHA; 22:6n3), trans-4-hydroxyproline, 7-ketodeoxycholate, 12-dehydrocholate, chenodeoxycholate, acetylcarnitine, palmitoleate (16:1n7), and mixtures thereof;

wherein the metabolites that modulate protein digestibility are selected from the group consisting of trigonelline (N′-methylnicotinate), X-09789, mannose, dihomo-linoleate (20:2n6), docosapentaenoate (n6 DPA; 22:5n6), X-11378, trans-4-hydroxyproline, arachidonate (20:4n6), X-17185, betaine, X-15461, N-acetylornithine, creatine, stachydrine, 4-hydroxyphenylacetate, eicosenoate (20:1n9), eicosenoate (20:1n11), campesterol, gamma-glutamylphenylalanine, pantothenate, mannitol, docosapentaenoate (n3 DPA; 22:5n3), adrenate (22:4n6), alpha linolenate (18:3n3), gamma linolenate (18:3n6), X-16975, glycerate, phenylalanine, oxidized glutathione (GSSG), palmitoleate (16:1n7), octanoylcarnitine, X-12450, erythritol, 3-hydroxybutyrate (BHBA), 3-(4-hydroxyphenyl)propionate, 1-heptadecanoylglycerophosphocholine, 3-phenyl propionate (hydrocinnamate), oleoyltaurine, and mixtures thereof; and

wherein the metabolites that modulate fiber digestibility are selected from the group consisting of 1-heptadecanoylglycerophosphoethanolamine, 1-palmitoylplasmenylethanolamine, 1-palmitoylglycerol (1-monopalmitin), alpha-tocopherol, ribitol, and mixtures thereof.

2. The method of claim 1 , wherein the composition comprises at least four distinct metabolites that modulate at least one of organic matter digestibility, dry matter digestibility, fiber digestibility, energy digestibility, fat digestibility or protein digestibility.

3. The method of claim 1 , wherein the composition comprises at least five distinct metabolites that modulate at least one of organic matter digestibility, dry matter digestibility, fiber digestibility, energy digestibility, fat digestibility or protein digestibility.

4. The method of claim 1 , wherein the method modulates at least two digestibilities selected from the group consisting of organic matter digestibility, dry matter digestibility, fiber digestibility, energy digestibility, fat digestibility and protein digestibility and wherein the composition comprises at least six distinct metabolites, three distinct metabolites for modulating each of the at least two digestibilities.

5. The method of claim 1 , wherein the method modulates at least three digestibilities selected from the group consisting of organic matter digestibility, dry matter digestibility, fiber digestibility, energy digestibility, fat digestibility and protein digestibility and wherein the composition comprises at least nine distinct metabolites, three distinct metabolites for modulating each of the at least three digestibilities.

6. The method of claim 1 , wherein the pet food composition provides at least a 5% increase or a 5% decrease in at least one of organic matter digestibility, dry matter digestibility, fiber digestibility, energy digestibility, fat digestibility or protein digestibility in the companion animal upon regular administration of the pet food to the companion animal.

7. The method of claim 1 , wherein the pet food composition is administered to the companion animal on a regular basis for long-term administration.

8. A method of modulating at least one of organic matter digestibility, dry matter digestibility, fiber digestibility, energy digestibility, fat digestibility or protein digestibility in a companion animal, comprising:

wherein the at least three distinct metabolites having trigonelline (N′-methylnicotinate) and mannose;

9. A method of modulating at least one of organic matter digestibility, dry matter digestibility, fiber digestibility, energy digestibility, fat digestibility or protein digestibility in a companion animal, comprising:

administering to the companion animal a pet food composition comprising protein, carbohydrates, fat, fiber, and at least three distinct metabolites for modulating at least one of organic matter digestibility, dry matter digestibility, fiber digestibility, energy digestibility, fat digestibility or protein digestibility in the companion animal, wherein the pet food composition is administered to the companion animal in an amount of about 3 g of the pet food composition per 1 lb body weight of the companion animal to about 16 g of the pet food composition per 1 lb body weight of the companion animal;

wherein the at least three distinct metabolites having trigonelline (N′-methylnicotinate) and mannose;

10. The method of claim 1 , wherein the at least three distinct metabolites are about 0.01 wt. % to about 10 wt. % of the pet food composition.

11. The method of claim 1 , wherein the pet food composition comprises the at least three distinct metabolites in an amount of about 1 IU of the at least three metabolites/kg of the pet food composition to about 500,000 IU of the at least three metabolites/kg of the pet food composition.

Assignments (5)

CORRECTIVE ASSIGNMENT TO CORRECT THE PATENT NUMBER 16062921 PREVIOUSLY RECORDED ON REEL 049391 FRAME 0756. ASSIGNOR(S) HEREBY CONFIRMS THE PATENT NUMBER SHOULD HAVE BEEN 16062912. Recorded Jul 3, 2020

From: NESTEC S.A.

To: SOCIÉTÉ DES PRODUITS NESTLÉ S.A.

Reel/Frame 054082/0001 →

From: NESTEC S.A.

To: SOCIÉTÉ DES PRODUITS NESTLÉ S.A.

Reel/Frame 054082/0165 →

CORRECTIVE ASSIGNMENT TO CORRECT THE ENGLISH TRANSLATION TO SHOW THE FULL AND CORRECT NEW NAME IN SECTION 51. PREVIOUSLY RECORDED AT REEL: 049391 FRAME: 0756. ASSIGNOR(S) HEREBY CONFIRMS THE MERGER. Recorded Jun 13, 2019

From: NESTEC S.A.

To: SOCIÉTÉ DES PRODUITS NESTLÉ S.A.

Reel/Frame 049853/0398 →

MERGER Recorded Jun 6, 2019

From: NESTEC S.A.

To: SOCIÉTÉ DES PRODUITS NESTLÉ S.A.

Reel/Frame 049391/0756 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 6, 2018

From: MIDDLETON, RONDO P; ZANGHI, BRIAN M; REZZI, SERGE ANDRE DOMINIQUE; HANNAH, STEVEN S

To: NESTEC SA

Reel/Frame 044843/0549 →

Cited By (1)

US 12,370,173