Lyophilization
Embodiments of methods, systems, and apparatuses for lyophilizing, storing, and transfusing materials are described. In embodiments, the materials may include whole blood or a component of whole blood such as plasma.
1. A container for lyophilizing and storing a lyophilized blood component, the container comprising:
a first chamber comprising:
a first wall made from a flexible polymeric material and comprising a first permeability to water vapor; and
a second wall attached to the first wall to define an interior volume of the first chamber, wherein at least a portion of the second wall comprises a region that has a second permeability to water vapor, the second permeability being higher than the first permeability;
a second chamber fluidly connectable to the first chamber through a pathway, the second chamber comprising:
a third wall made from a flexible polymeric material; and
a fourth wall attached to the third wall to define an interior volume of the second chamber; and
a seal in the pathway, the seal isolating the first chamber from the second chamber, wherein the seal may be opened to allow communication from the first chamber to the second chamber through the pathway.
2. The container of claim 1 , wherein the seal comprises one or more of a clamp, a weld, a frangible, or combinations thereof.
3. The container of claim 2 , wherein the first chamber further comprises a first port for adding a blood component into the interior volume of the first chamber.
4. The container of claim 3 , wherein the second chamber further comprises a second port for adding a rehydration fluid into the interior volume of the second chamber.
5. The container of claim 4 , wherein the second chamber further comprises a third port for removing a rehydrated blood component from the interior volume of the first chamber.
6. The container of claim 5 , wherein the at least a portion of the second wall comprises a nonwoven textile.