SMAC mimetic
A SMAC mimetic and pharmaceutical compositions thereof and methods of use.
1. A method for the treatment of breast cancer, prostate cancer, rectal cancer, head and neck cancers, gynecological tumors, bladder cancer and lymphoma in a mammal in need thereof that comprises administering an effective amount of Compound 15 of the following formula:
wherein R5 is —CH2CH3, or a pharmaceutically acceptable salt thereof, in combination with a second cancer therapy that is radiotherapy.
2. The method of claim 1 , wherein the radiotherapy is applied just to the localized area involved with a tumor.
3. The method of claim 2 , wherein the radiotherapy further comprises applying the radiotherapy to draining lymph nodes.
4. The method of claim 1 , wherein the radiotherapy is teletherapy.
5. The method of claim 1 , wherein the radiotherapy is sealed source radiotherapy.
6. The method of claim 2 wherein the tumor is a head and neck cancer.
7. The method of claim 6 , wherein the radiotherapy further comprises applying the radiotherapy to draining lymph nodes.
8. The method of claim 6 , wherein the radiotherapy is teletherapy.
9. The method of claim 6 , wherein the radiotherapy is sealed source radiotherapy.