Peptide compositions and methods for ameliorating skin laxity and body contour
Compositions and methods for amelioration of skin laxity and body contour are provided. Provided herein are compositions comprising a combination of peptides.
1. A topical composition for improving skin laxity, texture or crepiness, or for improving body contouring, comprising:
a tripeptide-1 present at 1-10 ppm,
a hexapeptide-11 present at about 0.001% to about 6% by weight, and
a hexapeptide-12 present at 0.5-10 ppm,
wherein the topical composition improves skin laxity or body contouring.
2. The topical composition of claim 1 , further comprising a tetrapeptide.
3. The topical composition of claim 2 , wherein the tetrapeptide is tetrapeptide-2.
4. The topical composition of claim 2 , wherein the tetrapeptide is present at 1-10 ppm.
5. The topical composition of claim 1 , further comprising ceramide NP, Tremella fuciformis extract, niacinamide, hydrogenated lecithin, C12-16 alcohols, palmitic acid, avocado extract, shea butter, bentonite, phytoene/phytofluene, hydroxymethoxyphenyl decanone, polyholosides, Plantago lanceolata , dill extract, phosphatidylserine, oleuropein, hydrolyzed Candida saitoana extract, Centella asiatica , propanediol, lecithin, Euglena gracilis extract, aqua, caffeine, Glaucium flavum leaf extract, or combinations thereof.
6. A method for improving skin laxity, texture or crepiness, or for improving body contouring, comprising administering the topical composition of claim 1 , wherein the topical composition improves skin laxity or body contouring.
7. The method of claim 6 , wherein the topical composition is administered in conjunction with a body-shaping procedure or following a body-shaping procedure.
8. The method of claim 6 , wherein the topical composition is administered up to one day following a body-shaping procedure.
9. The method of claim 8 , wherein the body-shaping procedure comprises high frequency focused ultrasound, pulsed focus ultrasound, cryolipolysis, radiofrequency induced electroporation, injectable lipolytic agents, liposuction, or combinations thereof.
10. The method of claim 6 , wherein the topical composition is administered one, two, three, four, five, or six times a day.
11. The method of claim 6 , wherein the topical composition is administered for at least one week, 2 weeks, 4 weeks, 8 weeks, or 12 weeks.
12. The method of claim 7 , wherein the body-shaping procedure is an invasive procedure.
13. The method of claim 7 , wherein the topical composition aids in eliminating post-surgical fat fragmentation and its effects.
14. The topical composition of claim 1 , wherein the hexapeptide-11 is present at about 0.002% to about 4% by weight.
15. The topical composition of claim 14 , wherein the hexapeptide-11 is present at about 0.005% to about 0.02% by weight.