IP Library › Granted Patent US 12,214,009
Granted Patent B2
US 12,214,009 · App. 18/212,119 · Granted Feb 4, 2025

Compositions and methods for improving bruising and rejuvenating skin

Inventors: Alan David Widgerow (Irvine, CA); John A. Garruto (Encinitias, CA)
Assignee: Alastin Skincare, Inc.
A61K38/06A61K9/0014A61K9/127A61K38/07A61K38/08A61K38/40A61P17/00A61P31/04
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Quick Facts
Patent No.
US 12,214,009
App. No.
18/212,119
Granted
Feb 4, 2025
Kind
B2
Abstract

Compositions and methods for improving bruising, stimulating elastin and/or collagen production, stimulating intrinsic hyaluronic acid production, stimulating adipogenesis, reducing inflammation, or combinations thereof are provided herein. Compositions and methods described herein may be used following a cosmetic procedure.

Claims (27)

1. A method for improving healing of a bruise or improving appearance of a bruise on human skin, the method comprising:

administering a topical composition to human skin that has been subjected to a medical procedure, wherein the topical composition comprises:

a tripeptide-1; and

a hexapeptide-11.

2. The method of claim 1 , wherein the medical procedure is an injection or an invasive surgery.

3. The method of claim 2 , wherein the injection comprises a filler or a neurotoxin.

4. The method of claim 1 , wherein the tripeptide-1 is present at a concentration of 1-10 ppm.

5. The method of claim 1 , wherein the hexapeptide-11 is present at a concentration of 50-150 ppm.

6. The method of claim 1 , wherein the composition further comprises at least one of a hexapeptide-12, a hexapeptide-38, or a tetrapeptide-2.

7. The method of claim 6 , wherein at least one of the hexapeptide-11, the hexapeptide-38, the hexapeptide-12, or the tetrapeptide-2 is encapsulated in a liposome.

8. The method of claim 7 , wherein the liposome comprises at least one of lactoferrin or phosphatidylserine.

9. The method of claim 1 , wherein the composition further comprises at least one of: Ledun palustre extract, dill extract, Tremella fuciformis extract, butylene glycol, glycerin, squalane, Dunaliella salina extract, phospholipids, tocopherol, ascorbyl palrnitate, xanthan gum, betaine, propanediol, lecithin, caprylic/capric triglyceride, caprylyl glycol, caprylyl methicone, phenoxy ethanol, ethylhexylglycerin, polyacrylate-13, polyisobutene, polysorhate 20, caprylhydroxamic acid, disodium EDTA, Arnica Montana extract, sorbitan isostearate, pentylene glycol, glucose, sunflower seed oil, radish root ferment filtrate, potassium sorbate, sodium hyaluronate crosspolyrner, xylilylglucoside, anhydroxyliml, xylitol, hydroxymethoxyphenyl decanone, or combinations thereof.

10. A method for improving healing of a bruise or improving appearance of a bruise on human skin, the method comprising:

administering a topical composition to human skin that has been subjected to a cosmetic procedure, wherein the topical composition comprises:

a tripeptide-1; and

a hexapeptide-11.

11. The method of claim 10 , wherein the cosmetic procedure is an injection of a filler, micro-needling, an injection of a neurotoxin, or an invasive surgery.

12. The method of claim 10 , wherein the tripeptide-1 is present at a concentration of 1-10 ppm.

13. The method of claim 10 , wherein the hexapeptide-11 is present at a concentration of 50-150 ppm.

14. The method of claim 10 , wherein the composition further comprises at least one of a hexapeptide-12, a hexapeptide-38, or a tetrapeptide-2.

15. The method of claim 14 , wherein at least one of the hexapeptide-11, the hexapeptide-38, the hexapeptide-12, or the tetrapeptide-2 is present in a liposome.

16. The method of claim 15 , wherein the liposome comprises at least one of lactoferrin or phosphatidylserine.

17. The method of claim 10 , wherein the composition further comprises at least one of: Ledum palustre extract, dill extract, Tremella fuciformis extract, butylene glycol, glycerin, squalane, Dunaliella salina extract, phospholipids, tocopherol, ascorbyl palmitate, xanthan gum, betaine, propanediol, lecithin, caprylic/capric triglyceride, caprylyl glycol, caprylyl nlethicone, phenoxy ethanol, ethylhexylglycerin, polyacrylate-13, polyisobutene, polysorbate 20, caprylhydroxamic acid, disodium EDTA, Arnica Montana extract, sorbitan isostearate, pentylene glycol, glucose, sunflower seed oil, radish root ferment filtrate, potassium sorbate, sodium hyaluronate crosspolymer, xylitylglucoside, anhydroxylitol, xylitol, hydroxymethoxyphenyl decanone, or combinations thereof.

18. A method for improving healing of a bruise or improving appearance of a bruise on human skin, the method comprising:

instructing the administration of a topical composition to human skin that has been subjected to a medical or cosmetic procedure, wherein the topical composition comprises:

a tripeptide-1; and

a hexapeptide-11.

Continuity (6)
Continuation 17384478 · Jul 23, 2021
Continuation PCTUS2020031867 · May 7, 2020
Provisional Application 62967383 · Jan 29, 2020
Provisional Application 62881783 · Aug 1, 2019
Provisional Application 62845063 · May 8, 2019
Related Publication 20230346875A1 · Nov 2, 2023
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