Granted Patent
B2
US 12,357,671 · App. 17/898,223 · Granted Jul 15, 2025
Compositions and methods for invasive and non-invasive procedural skincare
Assignee:
Alastin Skincare, Inc.
A61K38/08A61K8/26A61K8/37A61K8/416A61K8/42A61K8/4973A61K8/498A61K8/553A61K8/585A61K8/602A61K8/64A61K8/891A61K8/894A61K8/97A61K9/0014A61K31/01A61K31/047A61K31/16A61K31/231A61K31/353A61K31/47A61K31/685A61K31/695A61K31/7048A61K31/74A61K36/05A61K36/28A61K38/06A61K47/14A61K47/186A61K47/22A61K47/24A61K47/34A61Q19/00A61Q19/08A61K2300/00A61K2800/5922A61K2800/594A61K2800/75A61K2800/884
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Abstract
Compositions and methods for skincare treatment are provided. The invention relates more generally to skin care treatment and more particularly, to compositions and methods for promoting healthy skin, skin regeneration, skin repair, skin bed preparation, and enhanced wound healing.
Claims (35)
1. A topical composition, comprising:
a tripeptide-1 present at 0.5-50 ppm; and
a hexapeptide-12 present at 0.5-50 ppm,
wherein the tripeptide-1 and hexapeptide-12 synergistically promote skin repair or wound healing.
2. The topical composition of claim 1 , wherein the tripeptide-1 comprises palmitoyl tripeptide-1, myristoyl tripeptide-1, or a combination thereof.
3. The topical composition of claim 1 , wherein the hexapeptide-12 comprises palmitoyl hexapeptide-12, myristoyl hexapeptide-12, or a combination thereof.
4. The topical composition of claim 1 , wherein the topical composition is in the form of a cream.
5. The topical composition of claim 1 , wherein the tripeptide-1 is present at a concentration of 1-10 ppm.
6. The topical composition of claim 1 , wherein the hexapeptide-12 is present at a concentration of 1-10 ppm.
7. The topical composition of claim 1 , wherein the tripeptide-1 is present at a concentration of 1 ppm to 6 ppm.
8. The topical composition of claim 1 , wherein the hexapeptide-12 is present at a concentration of 1 ppm to 6 ppm.
9. The topical composition of claim 1 , wherein the composition further comprises an excipient selected from: caprylic/capric triglyceride, cetyl ethylhexanoate, cetearyl alcohol, squalane, niacinamide, dimethicone, cetearyl glucoside, glyceryl stearate, PEG-100 stearate, propanediol, ceramide 3, phytosterols, Butyrospermum parklii (shea butter), Olea europaea (olive) fruit oil, sodium hyaluronate, beta-glucan, hydrolyzed pea protein, Dunaliella salina extract, xylitylglucoside, anhydroxylitol, xylitol, glycerin, lecithin, caprylyl glycol, caprylhydroxamic acid, xanthan gum, disodium EDTA, ethylhexylglycerin, phenoxyethanol, or any combination thereof.
10. The topical composition of claim 1 , further comprising a tetrapeptide having the following amino acid sequence: GQPR.
11. A topical composition for application to skin around an eye, comprising:
0.5 ppm to 50 ppm of a tripeptide-1;
0.5 ppm to 50 ppm of a hexapeptide-12;
a tetrapeptide; and
at least one excipient selected from: caprylic/capric triglyceride, cetyl ethylhexanoate, cetearyl alcohol, squalane, niacinamide, dimethicone, cetearyl glucoside, glyceryl stearate, PEG-100 stearate, propanediol, ceramide 3, phytosterols, Butyrospermum parklii (shea butter), Olea europaea (olive) fruit oil, sodium hyaluronate, beta-glucan, hydrolyzed pea protein, Dunaliella salina extract, xylitylglucoside, anhydroxylitol, xylitol, glycerin, lecithin, caprylyl glycol, caprylhydroxamic acid, xanthan gum, disodium EDTA, ethylhexylglycerin, phenoxyethanol, or any combination thereof,
wherein the tripeptide-1 and the hexapeptide-12 synergistically promote skin repair or wound healing.
12. The topical composition of claim 11 , wherein the tetrapeptide comprises an amino acid sequence selected from: GQPR, KTFK, AQTR, or RSRK.
13. The topical composition of claim 12 , wherein the tetrapeptide comprises the amino acid sequence: glycine-glutamine-proline-arginine (GQPR).
14. The topical composition of claim 11 , wherein:
the tripeptide-1 comprises palmitoyl tripeptide-1; and
the hexapeptide-12 comprises palmitoyl hexapeptide-12.
15. The topical composition of claim 14 , wherein the tetrapeptide comprises palmitoyl tetrapeptide-7.
16. The topical composition of claim 11 , wherein any of the tripeptide-1, the hexapeptide-12, or the tetrapeptide is functionalized with palmitoyl or myristoyl group.
17. The topical composition of claim 11 , wherein the topical composition promotes skin restoration around the eye.
18. The topical composition of claim 11 , wherein the topical composition brightens skin around the eye.
19. A topical composition for application to skin around an eye, comprising:
0.5 ppm to 50 ppm of a tripeptide-1;
0.5 ppm to 50 ppm of a hexapeptide-12;
a tetrapeptide-7; and
at least one excipient selected from the group consisting of: of cyclopentasiloxane, tocopherol, caprylic/capri triglyceride, glyceryl stearate, PEG-100 stearate, dimethicone, carbomer, polyacrylate-13, disodium EDTA, glycerin, phenoxyethanol, ethylhexylglycerin, phospholipids, polysorbate 20, butylene glycol, or combinations thereof,
wherein the tripeptide-1 and the hexapeptide-12 synergistically promote skin repair or wound healing.
20. The topical composition of claim 19 , further comprising a buffer, wherein the buffer comprises at least one pH modifying agent selected from the group consisting of: calcium hydroxide, sodium hydroxide, potassium hydroxide, and combinations thereof.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 30, 2022
From: GARRUTO, JOHN A.; WIDGEROW, ALAN DAVID
To: ALASTIN SKINCARE, INC.,
Reel/Frame 060937/0352 →
Continuity (8)
Provisional Application
62303332
· Mar 3, 2016
Provisional Application
62291376
· Feb 4, 2016
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