Methods for fat reduction or elimination of lipid droplets
Compositions and methods for amelioration of skin laxity and body contour are provided. Provided herein are compositions comprising a combination of peptides.
1. A method for accelerating fat reduction or elimination of lipid droplets, the method comprising:
administering an effective amount of a topical composition comprising:
a tripeptide-1,
a hexapeptide-11, and
a hexapeptide-12,
wherein the topical composition accelerates fat reduction or elimination of lipid droplets.
2. The method of claim 1 , wherein the topical composition is administered in conjunction with a body-shaping procedure or following a body-shaping procedure.
3. The method of claim 1 , wherein the topical composition is administered up to one day following a body-shaping procedure.
4. The method of claim 1 , wherein the body-shaping procedure comprises high frequency focused ultrasound, pulsed focus ultrasound, cryolipolysis, radiofrequency induced electroporation, injectable lipolytic agents, liposuction, or combinations thereof.
5. The method of claim 1 , wherein the topical composition is administered one, two, three, four, five, or six times a day.
6. The method of claim 1 , wherein the topical composition is administered for at least one week, 2 weeks, 4 weeks, 8 weeks, or 12 weeks.
7. The method of claim 2 , wherein the body-shaping procedure is an invasive procedure.
8. The method of claim 1 , wherein the composition further comprises a tetrapeptide.
9. The method of claim 1 , wherein the hexapeptide-11 is present at about 0.001% to about 6% by weight.
10. The method of claim 1 , wherein the hexapeptide-12 is present at about 0.5-10 ppm.
11. The method of claim 1 , wherein the topical composition further comprises one or more additional ingredients selected from the group consisting of ceramide NP, Tremella fuciformis extract, niacinamide, hydrogenated lecithin, C12-16 alcohols, palmitic acid, avocado extract, shea butter, bentonite, phytoene/phytofluene, hydroxymethoxyphenyl decanone, polyholosides, Plantago lanceolata , dill extract, phosphatidylserine, oleuropein, hydrolyzed Candida saitoana extract, Centella asiatica , propanediol, lecithin, Euglena gracilis extract, water, caffeine, Glaucium flavum leaf extract, or combinations thereof.
12. The method of claim 1 , wherein the tripeptide-1 is present at 1-10 ppm.
13. The method of claim 8 , wherein the tetrapeptide is tetrapeptide-2.
14. The method of claim 8 , wherein the tetrapeptide is present at 1-10 ppm.
15. The method of claim 8 , wherein the hexapeptide-11 is present at about 0.002% to about 4% by weight.
16. The method of claim 8 , wherein the hexapeptide-11 is present at about 0.005% to about 0.02% by weight.
17. The method of claim 1 , wherein the hexapeptide-12 comprises palmitoyl hexapeptide-12, myristoyl hexapeptide-12, or a combination thereof.
18. The method of claim 1 , wherein the tripeptide-1 comprises palmitoyl tripeptide-1, myristoyl tripeptide-1, or a combination thereof.
19. The method of claim 13 , wherein the tetrapeptide-2 comprises acetyl tetrapeptide-2.
20. The method of claim 1 , wherein the hexapeptide-11 is formulated in a liposome.