Platforms for mitral valve replacement
A mitral valve prosthesis is percutaneously and/or transapically deployed in at least two stages. In a first stage, a mitral annular ring platform adapted for percutaneous delivery is delivered to and anchored in the mitral valve annulus. In the second stage, a valved-stent mitral valve prosthetic device adapted for percutaneously delivery is delivered to the mitral valve annulus for mounting in the mitral annular ring platform. This approach provides a consistent platform for accepting valved-stent mitral valve prosthetic devices from different vendors to be used.
1. A mitral valve prosthesis comprising:
a mitral ring platform adapted for delivery to a subject's mitral valve; and,
a valved-stent mitral valve prosthetic device,
wherein the mitral ring platform comprises a wire that when extended from a delivery catheter comprises three preformed, distinct but contiguous sections,
a first one of said sections occupying a first spatial plane and comprising at least one leading turn located at a distal end of the wire that is configured to wind the mitral ring platform in the subject's mitral valve,
a second one of said sections comprising at least two wound coils of which at least one coil occupies a second spatial plane that is substantially parallel to said first spatial plane, the second one of said sections being configured to provide anchoring for the valved-stent mitral valve prosthetic device by being sized in terms of diameter to fit securely within the subject's mitral valve annulus and whereby the at least two wound coils form a central void space that is configured for providing a landing zone for the valved-stent mitral valve prosthetic device and for ensuring that the valved-stent mitral valve prosthetic device retains a functioning valve mechanism and perivalvular sealing mechanism following insertion into the void space,
a third one of said sections comprising at least one trailing turn located at a proximal end of the wire, and being configured to maintain a position of the mitral ring platform relative to the subject's mitral valve prior to the deployment of the valved-stent mitral valve prosthetic device,
wherein the leading turn of the first one of said sections, the wound coils of the second one of said sections, and the trailing turn of the third one of said sections respectively include a radius of curvature, and the radius of curvature of the wound coils is smaller than the radius of curvature of the leading turn, and is smaller than the radius of curvature of the trailing turn,
wherein the mitral ring platform further comprises a first transition zone that represents a section of the wire that is contiguous with the third one of said sections and the second one of said sections and that angles away from the first spatial plane such that the second spatial plane is vertically spaced apart from the first spatial plane, and,
wherein said valved-stent mitral valve prosthetic device is configured to be delivered to the subject's mitral valve for mounting in said mitral ring platform.
2. The mitral valve prosthesis according to claim 1 wherein the mitral ring platform is configured to wind around leaflets and chordae of the subject's mitral valve.
3. The mitral valve prosthesis according to claim 1 , wherein the mitral ring platform is configured to create a platform at the subject's mitral valve that reduces the diameter of the mitral valve annulus in order to provide a suitable size and dimension for subsequent implantation of said valved-stent mitral valve prosthetic device within the second one of said sections.
4. The mitral valve prosthesis according to claim 1 , wherein the mitral ring platform is configured such that when it is positioned at the subject's mitral valve, the subject's mitral valve annulus is between the first and third sections of said platform.
5. The mitral valve prosthesis according to claim 1 , wherein the third one of said sections comprises a second transition zone that is contiguous with the second section.
6. The mitral valve prosthesis according to claim 1 wherein the first one of said sections of the mitral ring platform possesses a diameter in comparison to the subject's mitral valve to enable capture of leaflets of the subject and serving as a ventricular anchor for the mitral ring platform.
7. The mitral valve prosthesis according to claim 1 wherein the third one of said sections of the mitral ring platform possesses a diameter in comparison to the subject's mitral valve for serving as an atrial anchor for the mitral ring platform.
8. The mitral valve prosthesis according to claim 1 wherein said valved-stent mitral valve prosthetic device is balloon expandable.
9. The mitral valve prosthesis according to claim 1 wherein said valved-stent mitral valve prosthetic device is self-expandable.
10. The mitral valve prosthesis according to claim 1 , wherein the mitral ring platform and valved-stent mitral valve prosthetic device are configured for delivery by a transcatheter procedure.
11. A mitral ring platform that is adapted for delivery to a subject's mitral valve comprising a wire that when extended from a delivery catheter comprises three preformed, distinct but contiguous sections,
a first one of said sections occupying a first spatial plane and comprising at least one leading turn located at a distal end of the wire that is configured to wind the mitral ring platform in the subject's mitral valve,
a second one of said sections comprising at least two wound coils of which at least one coil occupies a second spatial plane that is substantially parallel to said first spatial plane, the second one of said sections being configured to provide anchoring for a valved-stent mitral valve prosthetic device by being sized in terms of diameter to fit securely within the subject's mitral valve annulus and whereby the at least two wound coils form a central void space that is configured for providing a landing zone for the valved-stent mitral valve prosthetic device and for ensuring that the valved-stent mitral valve prosthetic device retains a functioning valve mechanism and perivalvular sealing mechanism following insertion into the void space,
a third one of said sections comprising at least one trailing turn located at a proximal end of the wire, and being configured to maintain a position of the mitral ring platform relative to the subject's mitral valve prior to the deployment of the valved-stent mitral valve prosthetic device for mounting within the mitral ring platform,
wherein said first, second, and third sections of the mitral ring platform respectively include a radius of curvature, and the radius of curvature of the second section is smaller than the radius of curvature of the first one of said sections, and is smaller than the radius of curvature of the third one of said sections, and
the mitral ring platform further comprises a first transition zone that represents a section of the wire that is contiguous with the third one of said sections and the second one of said sections and that angles away from the first spatial plane such that the second spatial plane is vertically spaced apart from the first spatial plane,
wherein the mitral ring platform is configured to create a platform at the subject's mitral valve that reduces the diameter of the mitral valve annulus in order to provide a suitable size and dimension for subsequent implantation of a valved-stent mitral valve prosthetic device within the second one of said sections.