Methods of reducing mammographic breast density and/or breast cancer risk
The present disclosure is directed to generally methods for treating mammographic breast density and/or breast stiffness in a patient in need thereof, such as a premenopausal or perimenopausal patient, comprising the administration of an effective amount of androgenic agent and an effective amount of an aromatase inhibitor. These methods may also be useful in post-menopausal woman.
1. A method of treating mammographic breast density in a patient in need thereof, comprising administering to the patient:
i) an effective amount of androgenic agent, namely testosterone; and
ii) an effective amount of an aromatase inhibitor, namely anastrozole;
wherein the method further induces breast involution of breast cells in the patient.
2. The method of claim 1 , wherein the patient is peri-menopausal.
3. The method of claim 1 , wherein the patient is post-menopausal.
4. The method of claim 1 , wherein the patient is pre-menopausal.
5. The method of claim 2 , wherein a patient's breast has a mammographic breast density of 25% or greater via 2-D determination.
6. The method of claim 3 , wherein a patient's breast has a mammographic breast density of 25% or greater via 2-D determination.
7. The method of claim 4 , wherein a patient's breast has a mammographic breast density of 25% or greater via 2-D determination.
8. The method of claim 1 , wherein the method increases a patient's breast compression during mammographic visualization or detection of the breast.
9. The method of claim 5 , wherein the method increases the patient's breast compression during mammographic visualization or detection of the patient's breast.
10. The method of claim 6 , wherein the method increases breast compression during mammographic visualization or detection of the patient's breast.
11. The method of claim 7 , wherein the method increases breast compression during mammographic visualization or detection of the patient's breast.
12. The method of claim 1 , wherein the method reduces the mammographic breast density of a patient's breast between one or more annual intervening mammographic detections.
13. The method of claim 9 , wherein the method reduces the mammographic breast density of the patient's breast between one or more annual intervening mammographic detections.
14. The method of claim 10 , wherein the method reduces the mammographic breast density of the patient's breast between one or more annual intervening mammographic detections.
15. The method of claim 11 , wherein the method reduces the mammographic breast density of the patient's breast between one or more annual intervening mammographic detections.
16. The method of claim 13 , wherein the method reduces breast stiffness of the patient's breast between one or more annual intervening mammographic detections.
17. The method of claim 14 , wherein the method reduces breast stiffness of the patient's breast between one or more annual intervening mammographic detections.
18. The method of claim 15 , wherein the method reduces breast stiffness of the patient's breast between one or more annual intervening mammographic detections.