Substituted nucleosides, nucleotides and analogs thereof
Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HCV infection with one or more nucleotide analogs.
1. A method of making a compound of Formula 3i, or a pharmaceutically acceptable salt thereof:
comprising reacting the compound of Formula 3-1i with the corresponding phosphorochloridate reagent P-2i to form the compound of Formula 3-2i; and
reducing the compound of Formula 3-2i;
wherein R is selected from the group consisting of isopropyl, neopentyl and cyclohexyl.
2. The method of claim 1 , wherein reducing the compound of Formula 3-2i comprises combining the compound of Formula 3-2i with 10% Pd/C in a H2 atmosphere.
3. The method of claim 1 , wherein the compound of Formula 3i is
4. The method of claim 1 , wherein the compound of Formula 3i is
5. The method of claim 1 , wherein the compound of Formula 3i is