Pharmaceutical compositions comprising POH derivatives
The present invention provides for a perillyl alcohol (POH) carbamate, such as POH-Rolipram. The present invention also provides for a method of treating a disease such as cancer, by delivering to a patient a therapeutically effective amount of POH-Rolipram.
1. A composition comprising a perillyl alcohol carbamate, wherein the perillyl alcohol carbamate comprises perillyl alcohol conjugated with rolipram.
2. The composition of claim 1 , wherein the perillyl alcohol carbamate is 4-(3-cyclopentyloxy-4-methoxy phenyl)-2-oxo-pyrrolidine-1-carboxylic acid 4-isopropenyl cyclohex-1-enylmethyl ester.
3. A method for treating a glioblastoma in a mammal, comprising delivering to the mammal a therapeutically effective amount of the composition of claim 1 .
4. The method of claim 3 , further comprising treating the mammal with radiation.
5. The method of claim 3 , further comprising delivering to the mammal a chemotherapeutic agent.
6. The method of claim 3 , wherein the composition is administered by inhalation, intranasally, orally, intravenously, subcutaneously or intramuscularly.
7. The method of claim 6 , wherein the composition is administered intranasally using an atomizer.
8. The method of claim 3 , wherein the perillyl alcohol carbamate is 4-(3-cyclopentyloxy-4-methoxy phenyl)-2-oxo-pyrrolidine-1-carboxylic acid 4-isopropenyl cyclohex-1-enylmethyl ester.